Metastasi vescicale sincrona da melanoma Legramanti Stefano Cristinelli

Metastasi vescicale sincrona da melanoma Legramanti Stefano, Cristinelli Luca, Alghisi Roberta e Simeone Claudio Relatore : Legramanti Stefano

Melanoma Epidemiology • • Age : 30– 60 aa 10 vv in Caucasian Global incidence : 100. 000yr ( ) Italy : 7000 deadyr * Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute

Melanoma & Urinary tract • Extremely rare : 0, 1 – 0, 2 % of total cases • From 0, 1 % to 0, 5 % of Bladder Tumor • 20%-30% of metastatic neoplasms of the bladder originate from melanoma

Patient • • 63 years old • Hypertension • Resection of malignant melanoma of left shoulder and lymph node dissection for axillary lymph nodes metastasis in 10/2011

Patient EI : Melanoma tipo B-RAF wild type, Breslow 5, 5 mm, N 0

Case Report Douring Stadiation by TC scan : Bladder Lesion

Case Report • TURB (12/2011) : metastatic malignant melanoma of the urinary bladder • Ileal resection : M+ from Melanoma (01/2012) • KT (induction) : Fotemustina (03/2012) • TC–restaging : Desease progression

Case Report TC – restaging (05/2012) Desease progression Gallbladder Bladder

Case Report TUR-B

Case Report • LPS Colecistectomy (06/2012) • Planning radical cystectomy PET- TC Desease progression Adrenal gland – Bowel – Lymph nodes

Case Report PET - TC

Case Report • Stop radical cystectomy • New KT with Dacarbazina Dies 03/2012

Hot points • When to treat? • How to treat? • Who to treat?

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