Metabolism of Acylglycerols Sphingolipids Metabolism of AcylglycerolsPiry Overview

Metabolism of Acylglycerols & Sphingolipids Metabolism of Acylglycerols-Piry

Overview of acylglycerol biosynthesis 10/30/2020 Metabolism of Acylglycerols-Piry 2

ﺑﻴﻮﺳﻨﺘﺰ ﺳﺮﺍﻣﻴﺪ پﺎﻟﻤﻴﺘﻮﺋﻴﻞ کﻮآ Painful progressively deformed joints Subcutaneous nodules Fatal in early life + ﺳﺮﻳﻦ ﺳﺮﺍﻣﻴﺪ Farber disease ﺍﺳﻔﻨگﻮﺯﻳﻦ + ﺍﺳﻴﺪ چﺮﺏ 10/30/2020 Metabolism of Acylglycerols-Piry 9

Biosynthesis of sphingomyelin Niemann-pick disease Increased sphingomyeline Enlarged liver and spleen Mental retardation Fatal in early life 10/30/2020 Metabolism of Acylglycerols-Piry 10

Biosynthesis of Galactosylceramide and its Sulfatid Krabbe disease Galactocerebroside Mental retardation Blindness & Deafness Paralysis Absense of myelin Fatal in early life 10/30/2020 Metabolism of Acylglycerols-Piry 11

Biosynthesis of Gangliosides Gaucher disease 10/30/2020 Metabolism of Acylglycerols-Piry Tay-sachs disease Increased glucocerebrosid Enlarged liver and spleen Osteoporosis Mental retardation Increased ganglioside Mental retardation Blindness Muscular weakness seizures 12

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Cholestrol Metabolism 10/30/2020 Metabolism of Acylglycerols-Piry 14

Biosynthesis of cholesterol into five steps 1. Biosynthesis of Mevalonate 2. Formation of Isoprenoid Units 3. Six Isoprenoid Units Form Squalene 4. Formation of Lanosterol 5. Formation of Cholesterol 10/30/2020 Metabolism of Acylglycerols-Piry 15

ﺗﻨﻈﻴﻢ ﺳﺎﺧﺖ کﻠﺴﺘﺮﻭﻝ 10/30/2020 Metabolism of Acylglycerols-Piry 17

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