Metabolic Disorders in Animal Nutrition Anusorn Cherdthong Ph
Metabolic Disorders in Animal Nutrition Anusorn Cherdthong, Ph. D 137748 Applied Biochemistry in Nutritional Science Email: anusornc@kku. ac. th E-learning: http: //ags. kku. ac. th/e. Learning/137748
Introduction Mammary gland structure
Milk composition Ø 85% water ØLactose ØVitamin ØMinerals ØProtein: casein, whey protein ØFat
Milk composition (%) Animal Cow Goat Swine Human Water 87. 7 86. 6 81. 2 87. 6 Fat 3. 9 4. 1 6. 8 3. 8 Protein Lactose 3. 2 4. 9 3. 3 4. 7 4. 8 5. 5 1. 0 7. 0
Mc. Donald et al. (2011) Milk synthesis and substrates
Milk synthesis q. Lactose synthesis q. Protein synthesis q. FA synthesis
Lactose synthesis Mc. Donald et al. (2011)
Lactose synthesis Mc. Donald et al. (2011)
Protein synthesis q. Milk---casein and few of -lactalbumin, -lactoglobulin q. Occurred in endoplasmic reticulum and rough endoplasmic reticulum (RER) q. Substrates are AA: diet and microbial protein q. Protein product was storaged in golgi q. Mechanism protein synthesis similar to other organs
FA synthesis q. Occurred at smooth endoplasmic reticulum (SER) qtriacylglyceride is major product q. Storage in alveolus q. FA received from: q. Diet: intake, synthesis from C 2, C 4 q. Mobilization from adipose tissue
Milk synthesis control Brisken and O'Malley (2010)
Conclusion 1 Protein synthesis from diet and microbes 2 Lactose synthesis with 7 steps 3 FA synthesis as triacylglycerol by use VFA, diet as substrate
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