Mesenchymal stromal cells transiently alter the inflammatory milieu

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Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versushost disease by

Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versushost disease by Melinda E. Christensen, Brie E. Turner, Laura J. Sinfield, Katarina Kollar, Hannah Cullup, Nigel J. Waterhouse, Derek N. J. Hart, Kerry Atkinson, and Alison M. Rice haematol Volume 95(12): 2102 -2110 December 1, 2010 © 2010 by Ferrata Storti Foundation

MSC suppress T-cell proliferation and inflammatory cytokines in vitro. Melinda E. Christensen et al.

MSC suppress T-cell proliferation and inflammatory cytokines in vitro. Melinda E. Christensen et al. Haematologica 2010; 95: 21022110 © 2010 by Ferrata Storti Foundation

MSC administered 24 h post-transplant delay death from GVHD after MHC-mismatched HSCT. BALB/c mice

MSC administered 24 h post-transplant delay death from GVHD after MHC-mismatched HSCT. BALB/c mice (n=28 controls, n=18 MSC treated, 4 independent experiments) were transplanted with UBI-GFP/BL 6 bone marrow and splenocytes and treated mice administered dono. . . Melinda E. Christensen et al. Haematologica 2010; 95: 21022110 © 2010 by Ferrata Storti Foundation

MSC cause changes in IFNγ after MHC-mismatched HSCT. BALB/c mice were transplanted with UBI-GFP/BL

MSC cause changes in IFNγ after MHC-mismatched HSCT. BALB/c mice were transplanted with UBI-GFP/BL 6 bone marrow and splenocytes ± MSC on day +1. Melinda E. Christensen et al. Haematologica 2010; 95: 21022110 © 2010 by Ferrata Storti Foundation

MSC do not contribute to healing of GVHD target organs. Melinda E. Christensen et

MSC do not contribute to healing of GVHD target organs. Melinda E. Christensen et al. Haematologica 2010; 95: 21022110 © 2010 by Ferrata Storti Foundation

Impact of IFNγ pre-treatment of MSC, T-cell depletion or cyclosporine on survival after MHC

Impact of IFNγ pre-treatment of MSC, T-cell depletion or cyclosporine on survival after MHC mismatched HSCT. (A) BALB/c mice (n=12 controls, n=12 MSC treated, n=6 per remaining treatment groups, 2 independent experiments) were transplanted with UBI-GFP/BL 6. . . Melinda E. Christensen et al. Haematologica 2010; 95: 21022110 © 2010 by Ferrata Storti Foundation

Survival is increased after low dose MSC are infused 24 h after MHC-matched, mi.

Survival is increased after low dose MSC are infused 24 h after MHC-matched, mi. HA mismatched HSCT. BALB. B mice were transplanted with UBI-GFP/BL 6 bone marrow and splenocytes and administered at a low (4× 105/mouse) or high (1× 106/mouse) dose of MSC on day +1. . . Melinda E. Christensen et al. Haematologica 2010; 95: 21022110 © 2010 by Ferrata Storti Foundation

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Cardiac Nestin Mesenchymal Stromal Cells Enhance Healing ofCardiac Nestin Mesenchymal Stromal Cells Enhance Healing of
Bone marrow mesenchymal stromal cells induce nitric oxideBone marrow mesenchymal stromal cells induce nitric oxide
Hematopoietic stem cells in coculture with mesenchymal stromalHematopoietic stem cells in coculture with mesenchymal stromal