Mendelian Exceptions Mendelian Exceptions Mendel got lucky all

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Mendelian Exceptions

Mendelian Exceptions

Mendelian Exceptions Mendel got lucky – all 7 traits he studied showed complete (simple)

Mendelian Exceptions Mendel got lucky – all 7 traits he studied showed complete (simple) dominance.

Mendelian Exceptions Mendel got lucky – all 7 traits he studied showed complete (simple)

Mendelian Exceptions Mendel got lucky – all 7 traits he studied showed complete (simple) dominance. One allele is completely dominant over the other allele Homozygous dominant and heterozygous = same phenotype 1 allele is enough for full expression of dominant trait

Incomplete Dominance = the norm Heterozygote = intermediate phenotype 1 allele is not enough

Incomplete Dominance = the norm Heterozygote = intermediate phenotype 1 allele is not enough for full expression

Incomplete Dominance Ex: flower color R = red r = white RR x rr

Incomplete Dominance Ex: flower color R = red r = white RR x rr

Incomplete Dominance F 2: Rr x Rr

Incomplete Dominance F 2: Rr x Rr

Incomplete Dominance F 2: Rr x Rr 1 red 2 pink 1 white RR

Incomplete Dominance F 2: Rr x Rr 1 red 2 pink 1 white RR Rr Alleles not blended – still able to separate. Rr rr

Codominance – Both alleles are expressed equally

Codominance – Both alleles are expressed equally

Codominance – Both alleles are expressed equally Ex: Cows B = black W =

Codominance – Both alleles are expressed equally Ex: Cows B = black W = white BB = Black WW = White BW = ? ? ?

Codominance – Both alleles are expressed equally Ex: Cows B = black W =

Codominance – Both alleles are expressed equally Ex: Cows B = black W = white BB = Black WW = White BW = Black and white Other examples: calico cats, streaked flowers…

Multiple alleles Allele: Alternate forms of a gene Only 2 possible alleles in an

Multiple alleles Allele: Alternate forms of a gene Only 2 possible alleles in an individual, BUT any # of alleles may be present in a population due to mutations

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Alelles

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Alelles = A, B, O A & B = Dominant O = Recessive

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA A

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO A

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO A A

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO BB A A

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO BB A A B

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO BB BO A A B

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO BB BO A A B B

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO BB BO AB A A B B

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO BB BO AB A A B B AB (codom. )

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO BB BO AB OO A A B B AB (codom. )

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype

Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles Genotype Phenotype Alelles = A, B, O A & B = Dominant O = Recessive AA AO BB BO AB OO A A B B AB (codom. ) O

 Q: What combination of parents have an equal chance of having any of

Q: What combination of parents have an equal chance of having any of the 4 blood types?

 Q: What combination of parents have an equal chance of having any of

Q: What combination of parents have an equal chance of having any of the 4 blood types?

Mexican Hairless Dogs Hairless (H) is completely dominant over hairy (h). When two hairless

Mexican Hairless Dogs Hairless (H) is completely dominant over hairy (h). When two hairless are crossed: 2/3 hairless 1/3 hairy Why? ? ?

Mexican Hairless Dogs Hairless (H) is completely dominant over hairy (h). When two hairless

Mexican Hairless Dogs Hairless (H) is completely dominant over hairy (h). When two hairless are crossed: 2/3 hairless 1/3 hairy

Mexican Hairless Dogs Hairless (H) is completely dominant over hairy (h). When two hairless

Mexican Hairless Dogs Hairless (H) is completely dominant over hairy (h). When two hairless are crossed: 2/3 hairless 1/3 hairy HH Hh Hh hh

Mexican Hairless Dogs Hairless (H) is completely dominant over hairy (h). When two hairless

Mexican Hairless Dogs Hairless (H) is completely dominant over hairy (h). When two hairless are crossed: 2/3 hairless 1/3 hairy HH Hh Hh hh

Lethal Allele 2 copies of a lethal allele = death (usually stillborn) Hint: if

Lethal Allele 2 copies of a lethal allele = death (usually stillborn) Hint: if offspring ratio is x/3, think lethal allele (someone is dying)

Lethal Allele Q: How can we breed hairless dogs without stillborns?

Lethal Allele Q: How can we breed hairless dogs without stillborns?

3, 4, 5, etc. trait crosses If a pea plant that is TTRr. Pp

3, 4, 5, etc. trait crosses If a pea plant that is TTRr. Pp is crossed with a plant that is Ttrr. Pp, what percent of the offspring will be heterozygous for all three traits?

 If a pea plant that is TTRr. Pp is crossed with a plant

If a pea plant that is TTRr. Pp is crossed with a plant that is Ttrr. Pp, what percent of the offspring will be heterozygous for all three traits? Is there an easier way? ? ?

Product Rule Make a simple 4 square cross for each trait, then multiply the

Product Rule Make a simple 4 square cross for each trait, then multiply the results for each TT TT Rr Rr PP Pp Tt Tt rr rr Pp pp

Epistasis The process of one gene controlling the expression of another An epistatic gene

Epistasis The process of one gene controlling the expression of another An epistatic gene can completely mask the effects of another gene 2 genes -> 1 trait

Example: Lab Fur Color 2 genes are responsible for fur color: Black-brown gene Pigment

Example: Lab Fur Color 2 genes are responsible for fur color: Black-brown gene Pigment gene

Example: Lab Fur Color 2 genes are responsible for hair color: Black-brown gene Pigment

Example: Lab Fur Color 2 genes are responsible for hair color: Black-brown gene Pigment gene is epistatic (controls the expression of) over the Black-brown gene

Polygenic Inheritance Most traits (especially visible ones) are due to the interaction of multiple

Polygenic Inheritance Most traits (especially visible ones) are due to the interaction of multiple proteins, thus multiple genes As such, most traits do not follow simple Mendelian ratios