MENDELELIAN GENETICS 1 Gregor Mendel father of Genetics
- Slides: 48
MENDELELIAN GENETICS 1
Gregor Mendel “father of Genetics” Responsible for the Laws governing Inheritance of Traits 2
Gregor Johann Mendel §Austrian monk §Studied the inheritance of traits in pea plants §He found that the plants' offspring retained traits passed from parental generation 3
Genetic Terminology §Trait - any characteristic that can be passed from parent to offspring §Heredity - passing of traits from parent to offspring §Genetics - study of heredity 4
Types of Genetic Crosses §Monohybrid cross - cross involving a single trait e. g. flower color §Dihybrid cross - cross involving two traits e. g. flower color & plant height 5
Punnett Square Used to help solve genetics problems 6
Genetic Terminology §Alleles - two forms of a gene (dominant & recessive) §Dominant - stronger of two genes expressed in the hybrid; represented by a capital letter (R) §Recessive - gene that shows up less often in a cross; represented by a lowercase letter (r) 7
More Terminology §Genotype - gene combination for a trait (e. g. RR, Rr, rr) §Phenotype - the physical feature resulting from a genotype (e. g. round, wrinkle) 8
Genotype & Phenotype in Peas 9
Genotype & Phenotype in Peas Genotype of alleles: R = Round seeds r = Wrinkled seeds All genes occur in pairs, so 2 alleles affect a characteristic Possible combinations are: Genotypes RR Rr rr Phenotypes ROUND WRINKLED 10
Genotypes §Homozygous genotype - gene combination involving 2 dominant or 2 recessive genes (e. g. RR or rr); also called pure §Heterozygous genotype - gene combination of one dominant & one recessive allele (e. g. Rr); also called hybrid 11
Law of Dominance In a cross of parents that are pure for contrasting traits, only one form of the trait will appear in the next generation. All the offspring will be heterozygous and express only the dominant trait. RR x rr yields all Rr (round seeds) 12
Law of Dominance 13
Mendel’s Pea Plant Experiments 14
Why peas plants? §Can be grown in a small area §Produce lots of offspring §Produce pure plants when allowed to selfpollinate several generations §Can be artificially crosspollinated 15
Reproduction in Flowering Plants • Pollen contains sperm • Produced by the stamen • Ovary contains eggs • Found inside the flower Pollen carries sperm to the eggs for fertilization Self-fertilization can occur in the same flower Cross-fertilization can occur between flowers 16
Some Pea Plant Traits • Seed shape --- Round (R) or Wrinkled (r) • Seed Color ---- Yellow (Y) or Green (y) • Pod Shape --- Smooth (S) or wrinkled (s) • Plant Height --- Tall (T) or Short (t) • Flower color --- Purple (P) or white (p) 17
Generation “Gap” • Parental P 1 Generation = the parental generation in a breeding experiment. • F 1 generation = the first-generation offspring in a breeding experiment. • F 2 generation = the second-generation offspring in a breeding experiment. 18
Monohybrid Crosses 19
Monohybrid Cross • Trait: Plant Height • Alleles: T– Tall • Cross: Tall plants • TT x t – short x short plants tt T T t Tt Tt Genotype: Tt Phenotype: Phenotype tall Genotypic Ratio: All alike Phenotypic Ratio: All alike 20
Monohybrid Cross • Trait: Plant Height • Alleles: T– Tall • Cross: Tall plants • Tt x T T t TT Tt t – short x tall plants Tt tt Genotypic Ratio: 1 TT: 2 Tt: 1 tt Phenotypic Ratio: 3 tall: 1 short 21
Practice Your Crosses • Refer to page 179 • Provide the genotypic AND phenotypic ratios • 1. Cross a homozygous green seed with a heterozygous yellow seed • 2. Cross a heterozygous round plant with a heterozygous round plant • 3. Cross a homozygous purple seed with a homozygous white seed 22
Review of Monohybrid Crosses • Phenotype is based on Genotype • Each trait is based on two genes, one from the mother and the other from the father • True-breeding individuals are homozygous, which means both alleles are the same. 23
MENDEL’S LAWS 24
Law of Segregation • During the formation of gametes (eggs or sperm), the two alleles responsible for a trait separate from each other. • Alleles for a trait are then "recombined" at fertilization, producing the genotype for the traits of the offspring. 25
Applying the Law of Segregation 26
Law of Independent Assortment • Alleles for different traits are distributed to sex cells (& offspring) independently of one another. 27
Summary of Mendel’s laws LAW SUMMARY Law of Dominance A dominant allele completely masks the effects of a recessive allele. Law of Segregation Alleles are separated into individual gametes to transmit genetic information to offspring. Law of Independent Assortment Alleles on different chromosomes are distributed randomly to individual gametes. 28
Exceptions To Mendel’s Original Principles • Incomplete • Environmental dominance effects on gene • Co-dominance expression • Multiple alleles • Linkage • Polygenic traits • Sex linkage 29
Incomplete Dominance and Codominance 30
Incomplete Dominance • Neither allele is dominant • Heterozygotes have an intermediate phenotype • Example: Japanese “Four o’clock” flower • red (RR) x white (rr) RR = red flower rr = white flower r r R R 31
Incomplete Dominance Cross: red (RR) x white (rr) r r R Rr Rr All Rr = pink (heterozygous pink) 32
Incomplete Dominance Checking your understanding… Show a cross between 2 pink 4 o’clock flowers. Give the genotypic and phenotypic ratios. 33
Codominance • Neither allele is dominant and both alleles are expressed in heterozygous individuals. • Example: blood type 34
Codominance Problem • Example: Homozygous male Type B (IBIB) • x Heterozygous female Type A (IAi) IA i IB I AI B I Bi 50% = IAIB 50% = IBi 35
Another Codominance Problem • Checking your understanding… • Example: male Type O (ii) x female type AB (IAIB) IA IB i I Ai I Bi 50% = IAi 50% = IBi 36
Codominance • Critical Thinking Question: If a boy has a blood type O and his sister has blood type AB, what are the genotypes and phenotypes of their parents? • boy - type O (ii) X girl - type AB (IAIB) 37
Codominance • Answer: IA IB i i I AI B ii Parents: genotypes = IAi and IBi phenotypes = A and B 38
Sex-linked Traits • Traits (genes) located on the sex chromosomes • Sex chromosomes are X and Y • XX genotype for females • XY genotype for males • Many sex-linked traits carried on X chromosome • Examples: color blindness, hemophilia 39
Sex-linked Trait Problem • Example: Eye color in fruit flies • (red-eyed male) x (white-eyed female) XRY x X r. Xr • Remember: the Y chromosome in males does not carry traits. • RR = red eyed r r X X • Rr = red eyed • rr = white eyed • XY = male XR • XX = female Y 40
Sex-linked Trait Solution: Xr XR XR Xr Y Xr XR Xr Xr Y 50% red eyed female 50% white eyed male 41
Female Carriers 42
Genetic Practice Problems 43
Practice • tall (TT) x dwarf (tt) pea plants t t T T 44
Solution: Round (RR) vs. wrinkle (rr) pea plants R R r r Rr Rr All Rr= ROUND (heterozygous round) 45
practice • tall (Tt) vs. tall (Tt) pea plants T t 46
Solution: tall (Tt) x tall (Tt) pea plants T t T TT Tt tt 1/4 (25%) = TT 1/2 (50%) = Tt 1/4 (25%) = tt 1: 2: 1 genotype 3: 1 phenotype 47
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