MEIOSIS The great gene shuffling machine 2007 Paul
- Slides: 22
MEIOSIS The great gene shuffling machine © 2007 Paul Billiet ODWS Copyright Dr. Michael Knee Source: http: //hcs. osu. edu/hcs 300/
Meiosis performs two functions n n It halves the number of chromosomes to make haploid sets It shuffles the genes to produce new combinations (recombinations) © 2007 Paul Billiet ODWS
Meiosis and sexual reproduction n n Meiosis is needed to produce sex cells (gametes) with unpaired sets of chromosomes (haploid) Sex cells are used in fertilisation At fertilisation two sets of genes come together to form a hybrid with a set of paired chromosomes (diploid) The hybrid, whilst similar to the parents, is unique © 2007 Paul Billiet ODWS
Haploid and Diploid n n Karyotypes of somatic cells show paired sets of chromosomes The origin of the pairs are the maternal and paternal chromosomes of the egg and the sperm The number of types of chromosomes of a species is constant = n So the diploid (paired set) = 2 n © 2007 Paul Billiet ODWS
The sexual reproduction life cycle Diploid (2 n) Fertilisation Meiosis Haploid (n) © 2007 Paul Billiet ODWS
Meiosis a two step process n n Meiosis 1 is the reduction division Meiosis 2 resembles mitosis © 2007 Paul Billiet ODWS
Meiosis 1: Early Prophase 1 n n Chromosomes condense Homologous pairs linked by chiasmata (chiasma sing. ) © 2007 Paul Billiet ODWS
Meiosis 1: Late Prophase 1 n Spindle fibres form and spread out between the centrioles © 2007 Paul Billiet ODWS
Meiosis 1: Metaphase 1 n n The pairs of chromosomes line up on the equator The orientation of the maternal and the paternal chromosomes is random © 2007 Paul Billiet ODWS
Meiosis 1: Anaphase 1 n n Maternal and paternal chromosomes segregate (pulled separate on the spindle) They move to opposite poles © 2007 Paul Billiet ODWS
Meiosis 1: Metaphase 1 revisited n The pairs of chromosomes could orientate in different ways © 2007 Paul Billiet ODWS
Meiosis 1: Anaphase 1 revisited n n n Resulting in different combinations of chromosomes This means there are 2 n combinations In humans this means 223 or over 8 million combinations © 2007 Paul Billiet ODWS
Meiosis 2: Prophase 2 n n n Now the cells are haploid The chromosomes do not decondense at the end of meiosis 1 Each chromosome has still two chromatids © 2007 Paul Billiet ODWS
Meiosis 2: Prophase 2 n Spindles form again © 2007 Paul Billiet ODWS
Meiosis 2: Metaphase 2 n The chromosomes line up on the spindle equator independently © 2007 Paul Billiet ODWS
Meiosis 2: Anaphase 2 n n n The sister chromatids separate on the spindle Each cell will receive a copy of each chromosome type (i. e. it will receive n chromatids all different) The genes on the different chromosomes are recombined (shuffled) © 2007 Paul Billiet ODWS
Meiosis 2: Telophase 2 n Four haploid sex cells are produced © 2007 Paul Billiet ODWS
Crossing over n n n During prophase 1 not only do the homologous pairs link They exchange genetic material The genes on each chromosome are not identical they may be alleles Alleles are different versions of a gene e. g. Ear shape gene has two alleles the ear lobe allele and the no ear lobe allele © 2007 Paul Billiet ODWS
Meiosis: Anaphase 1 n n So when the pairs are separated, the alleles of the genes on the same chromosome are recombined (reshuffled) Genes on the same chromosome are called linked genes © 2007 Paul Billiet ODWS
Meiosis: Prophase 2 n n Each cell is haploid (n) The sister chromatids are no longer identical copies © 2007 Paul Billiet ODWS
Meiosis: Anaphase 2 n n At anaphase 2 the chromatids segregate (separate) randomly Even greater variation is achieved in the sex cells © 2007 Paul Billiet ODWS
Meiosis: Telophase 2 n n Thus an infinite variety of sex cells is possible Combined with random mating between males and females an infinite variety of individuals is conceived at fertilisation © 2007 Paul Billiet ODWS
- Oligonucleotide directed mutagenesis
- Caeccum
- Exon shuffling spiegazione
- Gene by gene test results
- Chapter 17 gene expression from gene to protein
- Mitosis vs meiosis
- Meisis 1 and 2
- Crossing over during prophase 1
- Chromosome disability
- Chapter 10 meiosis 1 and meiosis 2
- Chapter 10 section 10.2 meiosis worksheet answer key
- Image of prophase 2
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