Medical Mycology Systemic Mycoses Hugh B Fackrell Filename
Medical Mycology Systemic Mycoses Hugh B. Fackrell Filename; fungi_system. ppt 1 10/18/2021
Fungal Infections Opportunistic Infections l Superficial fungal infections l Cutaneous Mycoses l Subcutaneous Mycoses l l Systemic 2 Mycoses 10/18/2021
Systemic or Deep Mycoses l Histoplasmosis l Coccidiomycosis l Blastomycosis l Cryptococcosis 3 10/18/2021
Histoplasmosis before HIV l 4 Before the appearance of HIV, approximately 95% of the cases reported of histoplasmosis capsulati where inapparent, subclinical, or benign and five percent of them where a chronic progressive lung disease with chronic cutaneous or systemic disease, or an acute fulminating fatal systemic disease. 10/18/2021
Histoplasmosis After HIV Now the disease is almost always seen in HIV positive patients or other immunocompromised individuals. l All stages of this disease may mimic tuberculosis. l Histoplasmosis may coexist with actinomycosis, other mycoses, sarcoidosis, or tuberculosis. l 5 10/18/2021
Histoplasmosis Histoplasma capsulatum l Ohio, Mississippi valleys l 6 10/18/2021
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Coccidiomycosis l SW deserts, San Joaquin l Coccidioides immitus 9 10/18/2021
Valley Fever 10 10/18/2021
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Blastomycosis Blastomyces dermatitidi l as histo but rarer. l Canada- Manitoba and St. Lawrence river valley l Disease in horses. – Veternarians at risk. l 21 10/18/2021
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Cryptococcosis Cryptococcus neoformans l Sporadic l Pigeons l Meningitis form – fatal l 27 10/18/2021
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Systemic Mycoses: Disease Patterns 4 Subacute respiratory infection 4 Acute infection 4 Severe disseminated infection 32 10/18/2021
Systemic Mycoses: Subacute Respiratory Infection Low fever l Non-productive cough l Mild & self limiting l 33 10/18/2021
Systemic Mycoses: Acute Infections l l Productive cough purulent sputum pain in chest Weight loss. l l night sweats X-ray positive one, many lesions consolidation Differential diagnosis: pneumonia, tumour. 34 10/18/2021
Systemic Mycoses: Severe Disseminated Infections l Acute Infections + – spread to other organs – chronic Differential diagnosis t. b. 35 10/18/2021
Systemic Mycoses: Diagnosis 4 X-ray 4 Immunochemical 36 skin test serology 4 Microscopy Sputum biopsy autopsy 10/18/2021
Systemic Mycoses: Transmission Fungal spores inhaled. . . pneumonitis. . no human transmission Primary source bird and bat droppings and roosts. If roosts disturbed- dust, aerosol. Chickens, Pigeons, starlings. 37 10/18/2021
Systemic Mycoses: Treatment Amphotericin B and/or 5 -fluorocytosine 38 10/18/2021
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