Medical Mycology Classification of Mycoses Hugh B Fackrell
Medical Mycology Classification of Mycoses Hugh B. Fackrell Filename Fungi_classi. ppt 1 11/22/2020
Mycology: Study of fungi l Mycoses: fungal infections l Mytoxicosis- intoxicaton l 2 11/22/2020
Fungi l Molds- filamentous – Penicillium, mushrooms l Yeasts- unicellular – Fission yeasts – Budding Yeasts l 3 Dimorphic Fungi 11/22/2020
Molds & Fleshy Fungi Thallus: filaments of cells – visible mycelium l Hypha; individual filament – Septate hyphae – Coenocytic hyphae l Growth: l – at tip of hyphae – vegetative growth from fragments 4 11/22/2020
Vegetative Structures 5 11/22/2020
Mycelium Vegetative Hyphae l Reproductive Hyphae l – aerial hyphae above media – Reproductive spores 6 11/22/2020
Molds: Reproduction l Asexual – Grow from fragments – asexual spores l Sexual – Sexual spores ( less frequent) – two strains of fungi – fusion of nuclei 7 11/22/2020
Asexual Spores l Conidospore – Arthrospore – Blastospore l 8 Chlamydospore 11/22/2020
Conidiospore Asexual spore – Mitosis – Not enclosed by a SAC – chains l Conidiophore: filament that forms Conidospore l 9 11/22/2020
Conidio. Spores l Arthrospores – thickened fragments of septate hyphae – Coccidioides l Blastospores – thickened wall – Bud from the parent cell – Candida, Cryptococcus 10 11/22/2020
Chlamydospores l 11 Asexual spore contained within hypha 11/22/2020
Sporangium Sac of spores l Sporangiospore- Spores l Sproangiophore- aerial hypha with sporangium l 12 11/22/2020
Medically Important Fungi Deuteromycota- no sexual spores l Zygomycota- coenocytic fungi l Ascomycotal – septate – dust like spore l Basidomycota – septate – fleshy base; mushrooms 13 11/22/2020
Opportunistic mycoses Candidiasis l Aspergillosis, l Mucormycosis l Phycomycosis l 14 11/22/2020
Superficial Fungal Infections l Skin Infections – limited to Stratum corneum – do not penetrate deeper tissues l 15 No inflammation 11/22/2020
Superficial mycoses Black piedra l White piedra l Pityriasis vericolor l tinea nigra l 16 11/22/2020
Cutaneous Mycoses Dermatophytoses l Dermatomycoses l 17 11/22/2020
![Subcutaneous Mycoses Caused by trauma [puncture]and introduction of the fungus and bacteria. l Chromoblasomycosis](http://slidetodoc.com/presentation_image_h/842515cfede4e6929711a63823730961/image-18.jpg "Subcutaneous Mycoses Caused by trauma [puncture]and introduction of the fungus and bacteria. l Chromoblasomycosis")
Subcutaneous Mycoses Caused by trauma [puncture]and introduction of the fungus and bacteria. l Chromoblasomycosis l Phaeohypomycosis l Mycetoma l Sporotrichosis l 18 11/22/2020
Systemic or Deep Mycoses Histoplasmosis l Coccidiomycosis l Blastomycosis l Cryptococcosis l 19 11/22/2020
Cryptococcosis Cryptococcus neoformans l Sporadic l Pigeons l Meningitis form – fatal l 20 11/22/2020
Systemic Mycoses: Disease Patterns 4 Subacute respiratory infection 4 Acute infection 4 Severe disseminated infection 21 11/22/2020
Systemic Mycoses: Subacute Respiratory Infection Low fever l Non-productive cough l Mild & self limiting l 22 11/22/2020
Systemic Mycoses: Acute Infections l l Productive cough purulent sputum pain in chest Weight loss. l l night sweats X-ray positive one, many lesions consolidation Differential diagnosis: pneumonia, tumour. 23 11/22/2020
Systemic Mycoses: Severe Disseminated Infections l Acute Infections + – spread to other organs – chronic Differential diagnosis t. b. 24 11/22/2020
Presentation Outline l l l l 25 Disease Mechanisms l Entry l Adaptation l Propagation l Dissemination l Host Factors l Fungal Factors Classification of Mycoses site route virulence Epidemiology Fungal Diseases 11/22/2020
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