Medical Microbiology Department of Microbiology HMU Department of

Medical Microbiology Department of Microbiology, HMU Department of Microbiology, Harbin Medical University

第二篇 致病性细菌 第 14章 埃希菌属 Escherichia 微生物学教研室 张文莉 Department of Microbiology, Harbin Medical University

问题 大肠埃希菌与人类健康的关系如何？ n 肠道杆菌的共同特征？ n Department of Microbiology, Harbin Medical University

形态染色 0. 4 -0. 7µm 1 -3µm n 短杆菌 n 革兰染色阴性 n 有鞭毛 n 有菌毛 n Department of Microbiology, Harbin Medical University

Department of Microbiology, Harbin Medical University

大肠埃希菌于普通营养平板培养生长的菌落 Department of Microbiology, Harbin Medical University

抗原结构 O抗原：菌体抗原 n H抗原：鞭毛抗原 n K抗原：荚膜抗原 n O 111：K 58：H 2 n Department of Microbiology, Harbin Medical University

复杂的抗原构造 Department of Microbiology, Harbin Medical University

所致疾病 n 肠道外感染 u 泌尿道感染最多见 u 化脓性感染 n 腹泻 Department of Microbiology, Harbin Medical University

引起腹泻的大肠埃希菌 n n n 肠产毒型大肠埃希菌 ETEC 肠侵袭型大肠埃希菌 EIEC 肠致病型大肠埃希菌 EPEC 肠出血型大肠埃希菌 EHEC 肠集聚型大肠埃希菌 EAgg. EC enterotoxigenic E. coli enteroinvasive E. coli enteropathogenic E. coli enterohemorrhagic E. coli enteroaggregative E. coli Department of Microbiology, Harbin Medical University

Department of Microbiology, Harbin Medical University

Department of Microbiology, Harbin Medical University

Department of Microbiology, Harbin Medical University

Department of Microbiology, Harbin Medical University

Intimate Adherence of EHEC to Epithelial Cells Department of Microbiology, Harbin Medical University

The “life cycle” of E. coli O 157: H 7 5 -10% prevalence in animals 40% prevalence in farms Department of Microbiology, Harbin Medical University

肺泡巨噬细胞吞噬大肠埃希菌 Department of Microbiology, Harbin Medical University

微生物学检查法 标本 n 分离培养与鉴定 n u 肠道外感染 u 肠道内感染 Department of Microbiology, Harbin Medical University

防治原则 疫苗 n 抗生素的抗性质粒， 耐药性非常普遍 n Department of Microbiology, Harbin Medical University