Medical Microbiology Department of Microbiology HMU Department of
Medical Microbiology 医学微生物学 Department of Microbiology, HMU 哈尔滨医科大学微生物学教研室 Department of Microbiology, Harbin Medical University
分枝杆菌属 n 结核分枝杆菌 n 麻风分枝杆菌 n 非结核分枝杆菌 Department of Microbiology, Harbin Medical University
分枝杆菌属(Mycobacterium) 细长略带弯曲的杆菌 n 抗酸杆菌(acid-fast bacillus) n 分3组 n u 缓慢生长菌 u 迅速生长菌 u 特殊营养要求菌 Department of Microbiology, Harbin Medical University
结核分枝杆菌 Mycobacterium tuberculosis Tubercle bacilli
培养特性 n 专性需氧 n 生长缓慢 n 营养要求高 Department of Microbiology, Harbin Medical University
抵抗力 抗干燥 n 抗酸碱 n 抗染料 n 对酒精、湿热及紫外线敏感 n 对抗结核药物敏感 n Department of Microbiology, Harbin Medical University
变异性 n 形态、菌落、毒力及耐药性均可变异 n 卡介苗(Bacilli Calmette-Guèrin,BCG) n 结核分枝杆菌易发生耐药 Department of Microbiology, Harbin Medical University
致病物质 n 类脂(lipid) u 分枝菌酸(mycolic acid) u 索状因子(cord factor) u 磷脂(phosphatide) u 蜡质D(wax-D) 硫酸脑苷酯(sulfatide) 蛋白质 n 多糖(polysaccharide) n Department of Microbiology, Harbin Medical University
肺部感染-原发感染 多发生于儿童 n 原发综合征 n 形成结核结节 n 转归 n Department of Microbiology, Harbin Medical University
免疫机制 感染免疫、有菌免疫(infection immunity ) n 结核菌免疫依赖细胞免疫 n 可产生抗体,但其保护作用不明确 n Department of Microbiology, Harbin Medical University
Department of Microbiology, Harbin Medical University
结核菌素试验 n 结核菌素试剂 u 旧结核菌素(old tuberculin, OT) u 纯蛋白衍化物(purified protein derivative,PPD) Department of Microbiology, Harbin Medical University
麻风分枝杆菌 Mycobacterium leprae
培养特性 n 不能在人 培养基中生长 n 抗酸特性 n 动物模型:犰狳 Department of Microbiology, Harbin Medical University
麻风两型两类相互间的关系图 Department of Microbiology, Harbin Medical University
微生物学诊断 n 显微镜检查 n PCR Department of Microbiology, Harbin Medical University
非结核分枝杆菌 Nontuberculosis mycobacteria
光产色菌 偶发分枝杆菌 Department of Microbiology, Harbin Medical University
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