Medical Microbiology Department of Microbiology HMU Department of
Medical Microbiology 医学微生物学 Department of Microbiology, HMU 哈尔滨医科大学微生物学教研室 Department of Microbiology, Harbin Medical University
第三篇 医学相关病毒 第 33章 黄病毒 Flavivirus 微生物学教研室 宋武琦 Department of Microbiology, Harbin Medical University
虫媒病毒种类 n 虫媒病毒分属 3个病毒科: u 黄病毒科 (Flaviviruses) u 披膜病毒科 (Togaviruses ) u 布尼亚病毒科 (Bunyaviruses) Department of Microbiology, Harbin Medical University
黄病毒 Flaviviruses n 登革病毒 Dengue viruses n 流行性乙型脑炎病毒 Epidemic type B encephalitis virus n 蜱传脑炎病毒 Tick-borne encephalitis virus Department of Microbiology, Harbin Medical University
节肢动物媒介 Arthropod Vectors Aedes Aegyti (伊蚊) Culex Mosquito (库蚊) Assorted Ticks (虱、蜱) Phlebotmine Sandfly (吸血白蛉) Department of Microbiology, Harbin Medical University
传播环节 n人 – 节肢动物 – 人 n 动物 – 节肢动物 –人 n 混合方式:两种都有 Department of Microbiology, Harbin Medical University
Man-Arthropod-Man Cycle Dengue Reservoir may be in either man or arthropod vector In the latter transovarial transmission may take place Department of Microbiology, Harbin Medical University
Animal-Arthropod-Man Cycle Japanese encephalitis The reservoir is in an animal, The virus is maintained in nature in a transmission cycle involving the arthropod vector and animal Man becomes infected incidentally Department of Microbiology, Harbin Medical University
登革病毒 Dengue Virus Department of Microbiology, Harbin Medical University
Department of Microbiology, Harbin Medical University
生物学性状 n 呈哑铃状、棒状或 球形 n 55 nm, +ss. RNA, 有包 膜 n 4个血清型,有交叉反 应 Department of Microbiology, Harbin Medical University
临床特点 n 隐性感染率高 n 登革热 n 登革出血热、登革休 克综合症 Department of Microbiology, Harbin Medical University
微生物学检查法 n 病毒分离 n 血清学诊断 n 病毒核酸检测 Department of Microbiology, Harbin Medical University
预 防 n 预防措施的重点在于防蚊和灭蚊 n 减毒活疫苗 Department of Microbiology, Harbin Medical University
流行性乙型脑炎病毒 Epidemic type B encephalitis virus Department of Microbiology, Harbin Medical University
流行 Department of Microbiology, Harbin Medical University
生物学性状 n 单正链RNA n 有包膜 n 二十面立体对称 n 三种结构蛋白 n 抗原性稳定 Department of Microbiology, Harbin Medical University
Department of Microbiology, Harbin Medical University
微生物学诊断 n 血清学诊断 n 病毒抗原或核酸检测 n 病毒分离 Department of Microbiology, Harbin Medical University
Department of Microbiology, Harbin Medical University
森林脑炎病毒 Forest encephalitis virus Department of Microbiology, Harbin Medical University
Department of Microbiology, Harbin Medical University
防治原则 n 灭蜱、防蜱叮咬 n 接种灭活疫苗 Department of Microbiology, Harbin Medical University
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