Measurement and Control of Oxygen Saturation Levels in

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Measurement and Control of Oxygen Saturation Levels in Neonates http: //vubme. vuse. vanderbilt. edu/group

Measurement and Control of Oxygen Saturation Levels in Neonates http: //vubme. vuse. vanderbilt. edu/group 13_00 Group Members Advisors Charlie Artime John Penn, Ph. D Kit Eward Paul King, Ph. D Suzanne Flanary Heather Sweeney

Background • Studies published by our advisor, Dr. John Penn, and others concluded that

Background • Studies published by our advisor, Dr. John Penn, and others concluded that variability in blood oxygen saturation levels, along with prolonged exposure to hypoxic conditions, increases the risk for retinopathy of prematurity. 1, 2, 3 1. Penn JS, et al. “The range of Pa. O 2 variation determines the severity of oxygen-induced retinopathy in newborn rats. ” Invest. Ophthalmol. Vis. Sci. 1995 Sep; 36(10): 2063 -70. Yoshihiro Saito, et al. “The Progression of retinopathy of prematurity and fluctuation in blood gas tension” Graefe's Archive for Clinical and Experimental Ophthalmology 1993, 231: 151 -156 Penn JS, et al. “Arterial Oxygen Fluctuation and Retinopathy of Prematurity in Premature Infants” 2. 3.

Retinopathy of Prematurity • Develops in over 20% of all very low birth weight

Retinopathy of Prematurity • Develops in over 20% of all very low birth weight premature infants (<1500 g). • Characterized by abnormal blood vessel growth in the peripheral regions of the retina. • Leads to detachment of the retina and, in severe cases, blindness (13% of all ROP cases). • Leading cause of blindness in children.

Project Definition • Team project goal: design a computerbased integrator that recommends the proper

Project Definition • Team project goal: design a computerbased integrator that recommends the proper adjustment in Fi. O 2 to avoid fluctuation in Sa. O 2. • Ultimate goal: monitor and control, with minimum variation, the blood oxygen saturation level of neonates in order to avoid development of retinopathy.

Device Specifications 1. Pulse Oximeter • Heart Rate • Oxygen Saturation Level (Sa. O

Device Specifications 1. Pulse Oximeter • Heart Rate • Oxygen Saturation Level (Sa. O 2) 2. Integrator • Amount of O 2 needed to adjust inspired air (Fi. O 2) 3. Oxygen Blender • New Fi. O 2

IWB Diagram

IWB Diagram

How Our Device Will Help • Currently, when neonates exhibit a significant change in

How Our Device Will Help • Currently, when neonates exhibit a significant change in blood oxygen saturation, adjustments to the fraction of oxygen in the inspired air must be made by hand. • Typically, this results in an overshoot of the blood oxygen saturation of the neonate, and stabilization to the acceptable Sa. O 2 range can take hours. • This device can be used to help over 50, 000 premature infants born each year at risk for developing ROP.

Work Completed • Literature research • Preliminary experimentation with the respiratory gas monitor •

Work Completed • Literature research • Preliminary experimentation with the respiratory gas monitor • Established liaison with NICU • Worked with Innovation Workbench software • Met with Dr. Lindstrom; obtained IBM laptop and Ohmeda oximeter similar to those used in the NICU. • Established link between laptop and oximeter and tested data collection. • Obtained last year’s SIMON data from Patrick Norris.

Current Work • Making arrangements for data acquisition • Dr. Penn is currently contacting

Current Work • Making arrangements for data acquisition • Dr. Penn is currently contacting Dr. Lindstrom, Dr. Walsh, and several neonatology fellows. • Analyzing last year’s SIMON data. • Research the relationship between pulse rate and Sa. O 2 in infants. • Tour NICU

Future Work and Timeline Task Collect data from NICU Designsafe analysis Analyze data to

Future Work and Timeline Task Collect data from NICU Designsafe analysis Analyze data to determine trends Feb. March **** *** Determine monitor’s sensitivity characteristics **** Write program to interpret data and determine necessary adjustments ***** Test and Debug April ***

Acknowledgements • Dr. Paul King and Dr. John Penn - project advisors • Dr.

Acknowledgements • Dr. Paul King and Dr. John Penn - project advisors • Dr. Dan Lindstrom, Dr. Bill Walsh, and Dr. Kendall Graham -NICU • Patrick Norris • Dr. Richard Fries and Datex-Ohmeda