MARK BARTLETT PHD Vice President Global Research and
MARK BARTLETT, PHD Vice President, Global Research and Development Pharmanex
DIE YOUNG
Our product development efforts and investment enable us to CONTINUALLY REFRESH the vibrancy of the business opportunity through PRODUCT INNOVATION
Our anti-aging product strategy is to leverage LEADING EDGE SCIENCE to further understand the aging process. • Science in product development – – • Discovery process Development process Scientific assets – Multiple unique tools to discover and develop anti-aging products with meaningful benefits
AGELOC GENE TECHNOLOGY GENE EXPRESSION IN YOUNG TISSUE GENE EXPRESSION IN OLD TISSUE OLD GENE EXPRESSION AFTER AGELOC Gene Expression Scale Low Expression High Expression FIGURE DESCRIPTION: This heatmap illustrates gene expression of three groups from a preclinical test with one of the age. LOC Vitality ingredients: young (column 1), old (column 2), and old with age. LOC science (column 3). Each row represents one of 52 genes comprising the mitochondrial Youth Gene Cluster (mt. YGC). Columns 1 and 2 show that each of the 52 genes became more or less active during the aging process. In column 3, the YGC activity pattern of the old with age. LOC science group has been reset to a gene expression pattern similar to the young group in column 1. 1 Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22 -27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland. 1
• Our Science, Your guarantee 6 S Quality Process Selection; Sourcing; Standardization; Safety; Structure; Substantiation – – Quality Innovation Safety Substantiated claims
ANTI-AGING PRODUCT DEVELOPMENT PROCESS age. LOC science 6 S process TOOLKIT
R&D ENGINE - PROVO INNOVATION CENTER 8
R&D ENGINE CHINA INNOVATION PARK 9
NEW ANTI-AGING AGELOC TOOLS Life. Gen NOX Technologies • Patented technologies to study anti-aging interventions through gene expression science • Acquired November 2011 • Patented anti-aging technology • Incorporated in age. LOC Transformation and Galvanic Gels • Acquired November 2012
Healthy Aging Nutrition Science Antioxidant Science Gene Science ? ? ?
AGELOC GAMMA: WEIGHT MANAGEMENT SYSTEM Advanced age. LOC Products Simple Eating & Lifestyle Plan • AN ADVANCED WEIGHT MANAGEMENT SYSTEM that incorporates gene expression science • age. LOC Gamma helps you look slimmer and healthier in 90 days when used in conjunction with a healthy diet and exercise
AGELOC GAMMA: INFLUENCING WEIGHT • Key Tissues – There are key tissues that address critical areas of weight loss through gene expression. age. LOC Gamma will focus on these key tissues
AGELOC GAMMA
AGELOC GAMMA: STUDIES • Life. Gen (gene expression science) – Gene array analysis to elucidate YGCs • Clinical Studies – Open label study (ongoing) – Larger trial (starting in 2013)
GAMMA SYSTEM Incorporating age. LOC science and clinically demonstrated ingredients 18
AGELOC GAMMA REPRESENTS A MAJOR INNOVATION WITH GENE EXPRESSION SCIENCE
S 3: SCANNER UPGRADE COMING SUMMER 2013 • 25% smaller • Wireless • Battery operated
FUTURE PIPELINE INNOVATIVE age. LOC SKIN CARE and NUTRITION
AGELOC INNOVATION PATTERN 2010 2013 2020
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