Manganese Deficiency Unit 3 Dr Vivek Kr Singh

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Manganese Deficiency Unit 3 Dr. Vivek Kr. Singh Assistant Professor Department of Veterinary Clinical

Manganese Deficiency Unit 3 Dr. Vivek Kr. Singh Assistant Professor Department of Veterinary Clinical Complex

Introduction o Manganese is concerned with reproductive process and skeletal integrity o Involved in

Introduction o Manganese is concerned with reproductive process and skeletal integrity o Involved in several critical enzymatic pathways of glycosaminoglycan and collagen synthesis o Component of metalloenzymes, including superoxide dismutase (SOD) o Plays an important role in bone matrix formation and synthesis of chondroitin sulphate

Physiological Fuctions o Important physiological functions of Mn Ø Ø Ø Bone growth Reproduction

Physiological Fuctions o Important physiological functions of Mn Ø Ø Ø Bone growth Reproduction Metabolism of carbohydrates and lipids Immune activity Structure and function of brain cells

Etiology o Primary manganese deficiency is due to its low content in feedstuffs Plants

Etiology o Primary manganese deficiency is due to its low content in feedstuffs Plants grown on……. Ø Soil with low Mn content Ø Heavy leaching of soil Ø High p. H soil ……. are deficient in Mn content

Cont… q Secondary Mn deficiency is due to Ø Dietary excess of either calcium

Cont… q Secondary Mn deficiency is due to Ø Dietary excess of either calcium or phosphorus or both Ø Which leads to reduced Mn absorption Ø Excess dietary cobalt and Iron reduces Mn bio-availability

Epidemiology o Occurrence of primary Mn deficiency is not common in the country o

Epidemiology o Occurrence of primary Mn deficiency is not common in the country o Disorders generally caused due to secondary Mn deficiency

Pathogenesis o Mn Participates in various enzyme systems of the body, hence its deficiency

Pathogenesis o Mn Participates in various enzyme systems of the body, hence its deficiency affects various physiological functions, But the most important disorder is skeletal Malformation. Mn Deficiency Decreased Synthesis of Chondroitin Sulphate Malformation of bone matrix Skeletal Malformation

Treatment o Dietary supplementation with manganese, preferably in the form of sulphate or oxide

Treatment o Dietary supplementation with manganese, preferably in the form of sulphate or oxide o Manganese carbonate may also be used but bioavailability of Mn from its carbonate is lowest o Manganese sulphate followed by manganese oxide should be preferred

Cont… o Calves and heifers @ 50 mg of Mn/ Kg of DM o

Cont… o Calves and heifers @ 50 mg of Mn/ Kg of DM o Pigs @ 24 -57 mg Mn per 45 Kg BW o Manganese requirements for gestation and lactation are 20 ppm of diet

Quick Facts o Mn plays an imp. role in bonematrix formation and synthesis of

Quick Facts o Mn plays an imp. role in bonematrix formation and synthesis of chondroitin sulfate o It is essential in incorporating carbohydrates into mucopolysaccharides at the epiphyseal plates o Mn deficient diet of immature chicken and turkeys is one of the potential cause of perosis

Quick Facts o Mn deficient diet of breeder stock can lead to chondrodystrophy in

Quick Facts o Mn deficient diet of breeder stock can lead to chondrodystrophy in chicks embryos o Pyruvate corboxylase is a Mn dependent enzyme, involved in glucose and lipid metabolism o High Ca and P may reduce the absorption of Mn o Magnesium can play the role of Mn for some time in a few enzyme systems in the body

Thank You

Thank You

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