MAGNETIC RESONANCE AND ITS APPLICATIONS TO THE STUDY

MAGNETIC RESONANCE AND ITS APPLICATIONS TO THE STUDY OF BRAIN FUNCTION AND OTHER BIOLOGICAL TISSUES G 1 Group @ Physics Dept , Sapienza University of Rome Marbilab @ S. Lucia Foundation , Enrico Fermi Centre Bruno Maraviglia, Silvia Capuani, Girolamo Garreffa, Federico Giove, Tommaso Gili, Antonino M. Cassarà, Marco Carnì, Giovanni Giulietti, Marta Moraschi , Mauro Rebuzzi, Silvia De Santis

RESEARCH HUMAN SCALE Healthy P 300 nc. MRI Pathological Spinal f. MRI LBD Resting state Epilepsy Neuroenergetics PD OSAS Methods f. MRS Materials BNCT MRI Methods MQ MRI AD Modelling Experimental SMALL SCALE EEG/f. MRI Theory Experimental Modelling G 1 Group@Pyhs. Roma 1 / 2

Neuroenergetics: experimental Journal Cereb Blood Flow Metab 27: 1055 -1063 (2007) Magn Reson Imaging 24: 343 -348 (2006) G 1 Group@Pyhs. Roma 1 / 3

Neuroenergetics: modelling Journal Cereb Blood Flow Metab, under revision G 1 Group@Pyhs. Roma 1 / 4

Resting state Low frequency intrinsic correlations during rest the default network(s) 0. 01 Hz < f < 0. 08 Hz Greicius M et al PNAS 100: 253 -258 (2003) Fox MD et al PNAS 102: 9673 -9678 (2005) Damoiseaux JS et al 103: 13848 -13853 (2005) G 1 Group@Pyhs. Roma 1 / 5

Resting state Cognitve modulation of the Default Mode Network t-score G 1 Group@Pyhs. Roma 1 / Cereb Cortex, submitted 6

Resting state Healthy controls vs AD & MCI patients R t 5 12 10 4 8 3 6 2 1 0 4 2 0 H MCI AD Neurology, submitted G 1 Group@Pyhs. Roma 1 / 7

Spinal cord f. MRI Neuroimage, 42: 626 -634 (2008) G 1 Group@Pyhs. Roma 1 / 8

Neuronal current MRI Ultra Low Field NMR Neuroimage, 41: 1228 -1241 (2008) G 1 Group@Pyhs. Roma 1 / 9

Advanced MRI of biological tissues Trabecular Bone J Magn Reson Imaging, submitted Cartilage Biophys J, in preparation Boron Neutron Capture Therapy Int J Radiat Oncol Biol Phys, 562 -567 (2008). G 1 Group@Pyhs. Roma 1 / 10

RESOURCES PEOPLE: RESEARCH AGREEMENTS: Dipartimento di Fisica, Università “Sapienza”, Roma, Italy (2 professors, 1 researcher, 3 research fellows, 2 Ph. D student, 1 technician) Fondazione Santa Lucia, Roma, Italy (1 researcher, 1 research fellow, MDs) MAIN COLLABORATIONS: CMRR, University of Minnesota, Minneapolis, USA Brigham & Women's Hospital, Boston, USA University of California, Berkeley, USA Dipartimento di Scienze Neurologiche, Università “Sapienza”, Roma, Italy Istituto Neurologico Mediterraneo, Isernia, Italy G 1 Group@Pyhs. Roma 1 / 11

NMR Systems 3 T HEAD SYSTEM (HUMAN) Siemens Allegra Magnetic field: 3 T Imaging Gradients: 40 m. T/m Bore diameter: 63 cm RFPA: 4 k. W (1 H) System granted by: Fondazione Santa Lucia G 1 Group@Pyhs. Roma 1 / 12

NMR Systems 9. 4 T VERTICAL BORE SYSTEM Bruker Avance 400 Magnetic field: 9. 4 T Diffusion gradients: 40 m. T/m μ –Imaging gradients: 400 m. T/m High resolution Multinuclear Broad Band Observe Insert: 5 mm μ-Imaging probe Insert: 5 mm (1 H) Insert: 8 mm (1 H, 13 C, 23 Na) Insert: 8 mm (1 H, 13 C) Site granted by: Dipartimento di Fisica, Università di Roma “Sapienza” G 1 Group@Pyhs. Roma 1 / 13

NMR Systems 7 T HORIZONTAL BORE SYSTEM Bruker Biospec Magnetic field: 7 T Imaging gradients: 25 m. T/m μ –Imaging gradients: 40 m. T/m Bore diameter: 15 cm RFPA : 1 k. W System site granted by: Dipartimento di Fisica, Università di Roma “Sapienza” G 1 Group@Pyhs. Roma 1 / 14

NMR Systems EEG DEVICE EBNeuro Mizar 40 32/64 channels Sampling frequency: up to 16 k. Hz Dynamic range: 65. 5 m. V MRI compatibile G 1 Group@Pyhs. Roma 1 / 15

Neuronal current MRI Neuroimage 39: 87 -106 (2008) G 1 Group@Pyhs. Roma 1 / 16

Neuronal current MRI Neuroimage, cited G 1 Group@Pyhs. Roma 1 / 17

G 1 Group@Pyhs. Roma 1 / 18