LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2004 J Heart

AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS (Transplants: January 1986 - June 2003) ISHLT 2004

AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS (Transplants: January 1996 - June 2003) ISHLT 2004

AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS ISHLT (Transplants: January 1986 - June

AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS ISHLT (Transplants: January 1996 - June

Number of Transplants AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS By Year of Transplant 84

NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS ISHLT 2004 J Heart Lung Transplant 2004;

PEDIATRIC LUNG TRANSPLANTATION: Indications (Transplants: January 1991 - June 2003) DIAGNOSIS AGE: < 1

DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS Age: 11 -17 Years ISHLT 2004 J Heart Lung

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival for Congenital Diagnosis ISHLT 2004 J Heart Lung Transplant

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Procedure Type (Transplants: January 1990 - June 2002)

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Procedure Type Diagnosis: PPH (Transplants: January 1990 -

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Procedure Type Diagnosis: PPH (Transplants: January 1994 -

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2002)

PEDIATRIC LUNG TRANSPLANTATION Conditional Kaplan-Meier Survival by Age Group (Transplants: January 1990 - June

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Era ISHLT (Transplants: January 1988 - June 2002)

PEDIATRIC LUNG RECIPIENTS Functional Status (Follow-ups: April 1994 -June 2003) ISHLT 2004 J Heart

PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant ISHLT 2004 (Follow-ups: April 1994 - June 2003) J

PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression For follow-ups between January 2001 and June 2003 ISHLT

PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression (Follow-ups: January 2001 - June 2003) ISHLT 2004 J

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between January 2001

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up Report For follow-ups

POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups:

POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups:

Freedom from Bronchiolitis Obliterans For Pediatric Lung Recipients ISHLT 2004 (Follow-ups: April 1994 -

Freedom from Severe Renal Dysfunction* For Pediatric Lung Recipients (Follow-ups: April 1994 - June

MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (Follow-ups: April 1994 - June

Freedom from Malignancy For Pediatric Lung Recipients ISHLT 2004 (Follow-ups: April 1994 - June

PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause Of Death (Deaths: January 1992 - June 2003) CAUSE

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LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS (Transplants: January 1986 - June 2003) ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS (Transplants: January 1996 - June 2003) ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS ISHLT (Transplants: January 1986 - June 2003) 2004 J Heart Lung Transplant 2004; 23: 933 -947

AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS ISHLT (Transplants: January 1996 - June 2003) 2004 J Heart Lung Transplant 2004; 23: 933 -947

Number of Transplants AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS By Year of Transplant 84 84 84 73 47 51 56 45 43 20 1 3 ISHLT 4 67 66 6 2004 J Heart Lung Transplant 2004; 23: 933 -947 60

NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG TRANSPLANTATION: Indications (Transplants: January 1991 - June 2003) DIAGNOSIS AGE: < 1 Year Cystic Fibrosis PPH Congenital Heart Disease AGE: 1 -10 Years 66 35. 9% 7 14. 3% 25 13. 6% 23 46. 9% 20 10. 9% 13 7. 1% IPF Pulmonary Vascular Disease 6 12. 2% 6 3. 0% Re-TX: Non-OB 3 6. 1% 8 4. 3% 11 6. 0% OB (Non-Re. TX) 7 3. 8% Bronchiectasis 2 1. 1% COPD/Emphysema 2 1. 1% 24 13. 0% Re-TX: OB Other 10 ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947 20. 0%

DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS Age: 11 -17 Years ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival for Congenital Diagnosis ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947 (Transplants: January 1990 – June 2002)

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Procedure Type (Transplants: January 1990 - June 2002) P = 0. 0001 ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Procedure Type Diagnosis: PPH (Transplants: January 1990 - June 2002) P = 0. 0013 ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Procedure Type Diagnosis: PPH (Transplants: January 1994 - June 2002) P = 0. 0013 ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2002) ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG TRANSPLANTATION Conditional Kaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2002) HALF-LIFE <1 Year: ½-life = 7. 1 Years 1 -10 Years: ½-life = 6. 7 Years 11 -17 Years: ½-life = 6. 1 Years ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Era ISHLT (Transplants: January 1988 - June 2002) 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG RECIPIENTS Functional Status (Follow-ups: April 1994 -June 2003) ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant ISHLT 2004 (Follow-ups: April 1994 - June 2003) J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression For follow-ups between January 2001 and June 2003 ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression (Follow-ups: January 2001 - June 2003) ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between January 2001 and June 2003 ISHLT NOTE: Different patients are analyzed in Year 1 and Year 5 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between January 2001 and June 2003 1 Year Follow-up (N = 78) ISHLT 5 Year Follow-up (N = 45) NOTE: Different patients are analyzed in Year 1 and Year 5 2004 J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up Report For follow-ups between January 2001 and June 2003 ISHLT NOTE: Different patients are analyzed in Year 1 and Year 5 2004 J Heart Lung Transplant 2004; 23: 933 -947

POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994 - June 2003) ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994 - June 2003) ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

Freedom from Bronchiolitis Obliterans For Pediatric Lung Recipients ISHLT 2004 (Follow-ups: April 1994 - June 2003) J Heart Lung Transplant 2004; 23: 933 -947

Freedom from Severe Renal Dysfunction* For Pediatric Lung Recipients (Follow-ups: April 1994 - June 2003) * Severe renal dysfunction = Creatinine > 2. 5 mg/dl, dialysis or renal transplant ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947

MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (Follow-ups: April 1994 - June 2003) Malignancy/Type 1 -Year Survivors 5 -Year Survivors 345 (94. 3%) 63 (91. 3%) 21 (5. 7%) 6 (8. 7%) No Malignancy (all types combined) Malignancy Type ISHLT Lymph 19 Other 2 2004 J Heart Lung Transplant 2004; 23: 933 -947 6

Freedom from Malignancy For Pediatric Lung Recipients ISHLT 2004 (Follow-ups: April 1994 - June 2003) J Heart Lung Transplant 2004; 23: 933 -947

PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause Of Death (Deaths: January 1992 - June 2003) CAUSE OF DEATH 0 -30 Days (N = 45) 31 Days - 1 Year (N = 75) BRONCHIOLITIS 5 (6. 7%) ACUTE REJECTION 3 (4. 0%) LYMPHOMA 3 (4. 0%) CMV 5 (6. 7%) >1 Year - 3 Years (N = 81) 30 (37. 0%) >3 Years - 5 Years (N = 35) >5 Years (N = 11) 16 (45. 7%) 5 (45. 5%) 1 (2. 9%) 4 (4. 9%) 1 (2. 9%) 2 (18. 2%) INFECTION, NONCMV 6 (13. 3%) 31 (41. 3%) 17 (21. 0%) 8 (22. 9%) 1 (9. 1%) GRAFT FAILURE 20 (44. 4%) 14 (18. 7%) 16 (19. 8%) 3 (8. 6%) 2 (18. 2%) CARDIOVASCULAR 6 (13. 3%) 2 (2. 7%) 2 (2. 5%) TECHNICAL 6 (13. 3%) 1 (1. 3%) OTHER 7 (15. 6%) 11 (14. 7%) 12 (14. 8%) 6 (17. 1%) 1 (9. 1%) ISHLT 2004 J Heart Lung Transplant 2004; 23: 933 -947