LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2002 J Heart

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LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS ISHLT 2002 J Heart Lung Transplant 2002; 21:

AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS (1986 -2001) ISHLT 2002 J Heart

AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS (1986 -2001) ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

Number of Transplants AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS By Year of Transplant 85

Number of Transplants AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS By Year of Transplant 85 86 82 72 47 50 66 67 57 45 42 20 1 3 ISHLT 4 6 * Numbers may be low due to delayed reporting. 2002 J Heart Lung Transplant 2002; 21: 827 -840.

NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS ISHLT * Numbers may be low due

NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS ISHLT * Numbers may be low due to delayed reporting. 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG TRANSPLANTATION: Indications (1991 -2001) DIAGNOSIS AGE: < 1 Year Cystic Fibrosis PPH

PEDIATRIC LUNG TRANSPLANTATION: Indications (1991 -2001) DIAGNOSIS AGE: < 1 Year Cystic Fibrosis PPH Congenital Heart Disease AGE: 1 -10 Years 55 34. 2% 7 16. 7% 24 14. 9% 14 33. 3% 17 10. 6% 12 7. 5% IPF Pulmonary Vascular Disease 6 14. 3% 6 3. 7% Re-TX: Non-OB 3 7. 1% 8 5. 0% Re-TX: OB 9 5. 6% OB (Non-Re. TX) 6 3. 7% Bronchiectasis 2 1. 2% COPD/Emphysema 2 1. 2% 17 10. 6% Other 11 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840. 26. 2%

PEDIATRIC LUNG TRANSPLANTATION Indications by Age (1991 -2001) Age <1 Year ISHLT Age 1

PEDIATRIC LUNG TRANSPLANTATION Indications by Age (1991 -2001) Age <1 Year ISHLT Age 1 -10 Years 2002 J Heart Lung Transplant 2002; 21: 827 -840.

DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS Age: 11 -17 Years ISHLT 2002 J Heart Lung

DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS Age: 11 -17 Years ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Procedure Type (1990 -2001) P = 0. 006

PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Procedure Type (1990 -2001) P = 0. 006 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Age Group (1990 -2001) <1 Year: ½-life =

PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Age Group (1990 -2001) <1 Year: ½-life = 3. 5 Years 1 -10 Years: ½-life = 3. 5 Years 11 -17 Years: ½-life = 3. 2 Years ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG TRANSPLANTATION Conditional Actuarial Survival by Age Group (1990 -2001) <1 Year: ½-life

PEDIATRIC LUNG TRANSPLANTATION Conditional Actuarial Survival by Age Group (1990 -2001) <1 Year: ½-life = 7. 1 Years 1 -10 Years: ½-life = 5. 9 Years 11 -17 Years: ½-life = 5. 4 Years ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

Survival (%) PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Era (1988 -2001) ISHLT 2002 J

Survival (%) PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Era (1988 -2001) ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: PPH (1990 -2001) P =

PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: PPH (1990 -2001) P = 0. 002 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG RECIPIENTS Functional Status (April 1994 -December 2001) ISHLT 2002 J Heart Lung

PEDIATRIC LUNG RECIPIENTS Functional Status (April 1994 -December 2001) ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant ISHLT 2002 J Heart Lung Transplant 2002; 21: 827

PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840. (April 1994 - December 2001)

PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001 ISHLT

PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up Period For follow-ups between

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up Period For follow-ups between October 1999 and December 2001 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001 1 Year Follow-up (N = 76) ISHLT 5 Year Follow-up (N = 39) 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up Report For follow-ups between October

PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up Report For follow-ups between October 1999 and December 2001 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

POST-LUNG TRANSPLANT MORBIDITY For Pediatric Recipients (April 1994 -December 2000) ISHLT 2002 J Heart

POST-LUNG TRANSPLANT MORBIDITY For Pediatric Recipients (April 1994 -December 2000) ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

Freedom from Bronchiolitis Obliterans For Pediatric Lung Recipients (April 1994 -December 2000) ISHLT 2002

Freedom from Bronchiolitis Obliterans For Pediatric Lung Recipients (April 1994 -December 2000) ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

Freedom from Renal Dysfunction* For Pediatric Lung Recipients (April 1994 -December 2000) * Renal

Freedom from Renal Dysfunction* For Pediatric Lung Recipients (April 1994 -December 2000) * Renal dysfunction = Creatinine > 2. 5 mg/dl, dialysis or renal transplant ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (April 1994 -December 2001) Malignancy/Type

MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (April 1994 -December 2001) Malignancy/Type 1 -Year Survivors No Malignancy 288 (93. 5%) 45 (91. 8%) Malignancy (all types combined) 20 (6. 5%) 4 (8. 2%) Malignancy Type ISHLT Lymph 18 Other 2 2002 J Heart Lung Transplant 2002; 21: 827 -840. 5 -Year Survivors 4

Freedom from Malignancy For Pediatric Lung Recipients (April 1994 -December 2000) ISHLT 2002 J

Freedom from Malignancy For Pediatric Lung Recipients (April 1994 -December 2000) ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival Based on Rejection within 1 st Year (1994 -2000)

PEDIATRIC LUNG TRANSPLANTATION Actuarial Survival Based on Rejection within 1 st Year (1994 -2000) Survival (%) P= 0. 01 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG RECIPIENTS Relationship of Diabetes and Cystic Fibrosis Transplants: April 1994 – December

PEDIATRIC LUNG RECIPIENTS Relationship of Diabetes and Cystic Fibrosis Transplants: April 1994 – December 2000 Diagnosis Report of Diabetes Developing Between Transplant and 1 st Year* Transplant and 3 rd Year** No Yes Cystic Fibrosis 103 70. 1% 44 29. 9% 29 55. 8% 23 44. 2% Other Diagnosis 137 97. 3% 4 2. 8% 53 94. 6% 3 5. 4% *p < 0. 0001 ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840. **p < 0. 0001

PEDIATRIC LUNG RECIPIENTS: Time Of Death (1988 -2001) ISHLT 2002 J Heart Lung Transplant

PEDIATRIC LUNG RECIPIENTS: Time Of Death (1988 -2001) ISHLT 2002 J Heart Lung Transplant 2002; 21: 827 -840.

PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause of Death (1982 -2001) ISHLT Timing of Death 2002

PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause of Death (1982 -2001) ISHLT Timing of Death 2002 J Heart Lung Transplant 2002; 21: 827 -840.