LUNG TRANSPLANTATION Overall 2013 JHLT 2013 Oct 3210

Adult and Pediatric Lung Transplants Number of Transplants by Year and Procedure Type 3747

Adult and Pediatric Lung Transplants 60 24 50 20 40 16 30 12 55

Adult and Pediatric Lung Transplants Average Center Volume by Location (Transplants: January 2000 –

Adult and Pediatric Lung Transplants 80% 48 60% 36 40% 24 20% 12 0%

Adult and Pediatric Lung Transplants Recipient Age Distribution (Transplants: January 1985 – June 2012)

Adult and Pediatric Lung Transplants Recipient Age Distribution by Era 40 1985 -1994 (N

Adult and Pediatric Lung Transplants 80% 40 60% 30 40% 20 20% 10 0%

Adult and Pediatric Lung Transplants Donor Age Distribution (Transplants: January 1985 – June 2012)

Adult and Pediatric Lung Transplants Donor Age Distribution by Era 40 p < 0.

Adult and Pediatric Lung Transplants Donor and Recipient Age (Transplants: January 1985 – June

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LUNG TRANSPLANTATION Overall 2013 JHLT. 2013 Oct; 32(10): 965 -978

Adult and Pediatric Lung Transplants Number of Transplants by Year and Procedure Type 3747 3500 Bilateral/Double Lung 3000 Single Lung 3279 29222981 2795 2571 2500 2000 1500 1289 1160 2218 2012 1975 1784 1700 1547 1559 1510 1412 1389 970 1000 758 450 500 0 3519 5 7 38 89 204 19 8 19 5 8 19 6 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 11 Number of Transplants 4000 2013 JHLT. 2013 Oct; 32(10): 965 -978 NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as representing changes in the number of lung transplants performed worldwide.

Adult and Pediatric Lung Transplants 60 24 50 20 40 16 30 12 55 20 32 8 38 25 10 16 4 10 0 1 -4 5 -9 10 -19 20 -29 30 -39 40 -49 Average number of lung transplants per year Number of centers Percentage of transplants 2013 JHLT. 2013 Oct; 32(10): 965 -978 7 50+ 0 % of Transplants Number of Centers Average Center Volume (Transplants: January 2000 – June 2012)

Adult and Pediatric Lung Transplants Average Center Volume by Location (Transplants: January 2000 – June 2012) 35 Number of Centers 30 Europe 25 25 20 North America Other 19 17 15 11 18 13 13 13 12 10 10 6 5 5 3 1 0 0 1 -4 5 -9 10 -19 20 -29 30 -39 3 5 2 40 -49 Average number of lung transplants per year 2013 JHLT. 2013 Oct; 32(10): 965 -978 5 2 0 50+

Adult and Pediatric Lung Transplants 80% 48 60% 36 40% 24 20% 12 0% 0 Year of Transplant 0 -11 12 -17 18 -34 35 -49 2013 JHLT. 2013 Oct; 32(10): 965 -978 50 -59 60 -65 >65 Median Age Median recipient age (years) 60 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 12 100% 19 % of Transplants Recipient Age by Year (Transplants: January 1987 – June 2012)

Adult and Pediatric Lung Transplants Recipient Age Distribution (Transplants: January 1985 – June 2012) 35 % of Transplants 30 25 20 15 10 5 0 0 -11 12 -17 18 -29 30 -39 40 -49 Recipient Age 2013 JHLT. 2013 Oct; 32(10): 965 -978 50 -59 60 -65 >65

Adult and Pediatric Lung Transplants Recipient Age Distribution by Era 40 1985 -1994 (N = 4, 973) % of Transplants 35 30 25 1995 -2004 (N = 17, 105) 2005 -6/2012 (N = 23, 220) p < 0. 0001 20 15 10 5 0 0 -11 12 -17 18 -29 30 -39 40 -49 50 -59 60 -65 >65 Recipient Age 2013 JHLT. 2013 Oct; 32(10): 965 -978 Transplants with unknown recipient age were excluded from this tabulation.

Adult and Pediatric Lung Transplants 80% 40 60% 30 40% 20 20% 10 0% 0 Median donor age (years) 50 8 19 7 8 19 8 8 19 9 9 19 0 9 19 1 9 19 2 9 19 3 9 19 4 9 19 5 9 19 6 9 19 7 9 19 8 9 20 9 0 20 0 0 20 1 0 20 2 0 20 3 0 20 4 0 20 5 0 20 6 0 20 7 0 20 8 0 20 9 1 20 0 1 20 1 12 100% 19 % of Transplants Donor Age by Year (Transplants: January 1987 – June 2012) Year of Transplant 0 -11 12 -17 18 -29 30 -39 40 -49 2013 JHLT. 2013 Oct; 32(10): 965 -978 50 -59 60 -65 >65 Median Donor Age

Adult and Pediatric Lung Transplants Donor Age Distribution (Transplants: January 1985 – June 2012) 35 % of Transplants 30 25 20 15 10 5 0 0 -11 12 -17 18 -29 30 -39 40 -49 Donor Age 2013 JHLT. 2013 Oct; 32(10): 965 -978 50 -59 60 -65 >65

Adult and Pediatric Lung Transplants Donor Age Distribution by Era 40 p < 0. 0001 1985 -1994 (N = 4, 524) 35 1995 -2004 (N = 16, 823) 2005 -6/2012 (N = 23, 105) % of Transplants 30 25 20 15 10 5 0 0 -11 12 -17 18 -29 30 -39 40 -49 50 -59 60 -65 >65 Donor Age 2013 JHLT. 2013 Oct; 32(10): 965 -978 Transplants with unknown donor age were excluded from this tabulation.

Adult and Pediatric Lung Transplants Donor and Recipient Age (Transplants: January 1985 – June 2012) Donor Age: 0 -11 12 -17 18 -29 30 -39 40 -49 50 -59 60 -65 >65 100% % of Transplants 80% 60% 40% 20% 0% 0 -11 12 -17 18 -29 30 -39 40 -49 Recipient Age 2013 JHLT. 2013 Oct; 32(10): 965 -978 50 -59 60 -65 >65