LTD LTP AMPAR According to Shi et al

LTD 와 LTP에서 AMPA-R ; 주의 깊게 살펴보기 According to Shi et al LTP and LTD can arise from the rapid redistribution (insertion in LTP or retrieval in LTD) of Glutamate AMPA receptors after synaptic NMDA receptor activation depending on the stimulus properties. (Science 1999, 284: 1811 -16)

Long-term potentiation in the hippocampus A: 3 major pathway B: The early and late phases of LTP in the Schaffer collateral pathway C: Model for the late phase of LTP in the Schaffer collateral pathway 출처: 김갑중 원장님”기억을 찾아서” 발표자료 참고

A dialogue between genes and synapses 등장인물 check : CREB-1, PKA, c. AMP, MAPK, 5 HT 출처: 김갑중 원장님”기억을 찾아서” 발표자료 참고

기억에 관련된 등장인물 살펴보기 CREB, c. AMP, PKA, Ca. MK II, Ca++, NMDA, 기타 CREB ; (c. AMP response element-binding) proteins are transcription factors : 단백질 전사인자 CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression.

DNA : Deoxyribonucleic acid DNA 4주인공: Adenine, Guanine, Cytosine, Thymine The structure of part of a DNA_chemical_structure. svg

Signal transduction in Parietal Cells CAMK

NMDA : N-methyl-D-aspartic acid Ca 2+ 을 통과 시키는 수용체. NMDA. svg

Calcium works through calcium binding proteins

출처: Lisman neuroscience 2002

Ca. MK II : Ca 2+/calmodulin-dependent protein kinase 칼슘이 칼모듈린에 붙어서 인산기 매개 역할. 단백질 발판과 같은 PDS-95 만들어지면서 AMPA 수용체 들어남. Calmodulin can bind to calmodulindependent-protein kinase II-alpha Ca. M Kinase. Calmodulin 3 D structure