Losing weight THE GUT AND ENERGY BALANCE 11307120262
Losing weight
THE GUT AND ENERGY BALANCE 11307120262 Weng. Shanshan
![The Gut and Energy Balance[1] Part 1: gut’s role in energy balance Part 2:](http://slidetodoc.com/presentation_image_h2/7433bb31a4fb12d6f015ddbeff5fdfb0/image-3.jpg "The Gut and Energy Balance[1] Part 1: gut’s role in energy balance Part 2:")
The Gut and Energy Balance[1] Part 1: gut’s role in energy balance Part 2: obesity therapy [1]The Gut and Energy Balance: Visceral Allies in the Obesity Wars. Michael K. Badman and Jeffrey S. Flier. Science 307, 1909 (2005).
Controller of Energy Balance Hypothalamus(esp. arcuate nucleus) long-term energy store short-term energy store Hindbrain short-term energy store
Controller of Energy Balance
Signals of Long-term Energy Balance pancreatic β cells insulin barrier insulin receptors blood-brain Function: Regulate the storage of absorbed nutrients Reduce appetite Potentiate satiety factors
Signals of Long-term Energy Balance adipocyte leptin receptors blood-brain barrier Lack of leptin(or its recepter) will lead to: lower energy expenditure and fecundity hyperphagic and obese
The Enteric Nervous System Vagal : chemical stimuli, physiological stimuli Splanchnic : noxious stimuli
Humoral Messengers of Gut Function stomach, proximal small intestine, distal ileum, and colon gut peptidse gastrointestinal exocrine glands, smooth muscle, afferent nerve terminals, and the brain gut hormone chemical signal receptor cell FFA GPR 120 GLP-1–containing cells GLP-1 FFA GPR 40 to GPR 43 β cells insulin aromatic calcium sensing amino receptor acids chemical signal receptor PPARα glucose ATP-sensitive fatty acid potassium oleylethanolamide pathway vagal mechanism GLP-1
Peptides category satiety hunger peptide source CCK duodenum and jejunum OXM L cells GLP-1 L cells GIP K cells NPY PP arcuate nucleus PYY ileum and colon PP specific pancreatic islet cells ghrelin the fundus of the stomach
Peptides
Surgery
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