Lipoproteins Harvey RA Champe PC Lippincott Illustrated Biochemistry

Lipoproteins Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005

Lipoproteins are spherical macromolecular complexes of lipids and specific proteins (apolipoproteins) Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005

Composition of plasma lipoproteins Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005

Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005

Chylomicrons Lippincott Fig. 18. 19 Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005

Lippincott Fig. 18. 19 Major classes of lipoprotein particles Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005 4

Lipoproteins TYPES : • Chylomicrons • Very low density lipoprotein (VLDL) • low density lipoprotein (LDL) • High density lipoprotein (HDL) • Functions To keep their component lipids soluble as they transport them in the plasma To provide an efficient mechanism transporting lipids to and from the tissues Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005

Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005

Lipoprotein lipase §It is a an extracellular enzyme and bound to the capillary walls of most tissues but predominately to adipose tissue and also cardiac and skeletal muscle. §Activated by Apo C-II §Hydrolyzes the triacylglycerol contained in the chylomicron §Patients with deficiency of lipoprotein lipase or Apo C-II (type 1 hyperlipoproteinemia or familial lipoprotein lipase defeicency ) show a dramatic accumulation of chylomicrons in the plasma (hypertriacylglycerolemia) Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005

Harvey RA, Champe PC. Lippincott Illustrated Biochemistry 3 rd Edition, 2005