LIPIDS 1 DR AQSA MALIK Definition Heterogeneous group

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LIPIDS 1 DR. AQSA MALIK

LIPIDS 1 DR. AQSA MALIK

Definition �Heterogeneous group of compounds �Relatively insoluble in water � soluble in non-polar solvents

Definition �Heterogeneous group of compounds �Relatively insoluble in water � soluble in non-polar solvents such as ether, benzene, chloroform, acetone � Bulk of lipids is non-polar although it contain certain ionized groups--

Building blocks are � Fatty Acids � Glycerol � Sphingosine � sterols

Building blocks are � Fatty Acids � Glycerol � Sphingosine � sterols

BIOMEDICAL IMPORTANCE � Storage form of energy-9 Kilocalories/g � Structural component of biological membranes—cell

BIOMEDICAL IMPORTANCE � Storage form of energy-9 Kilocalories/g � Structural component of biological membranes—cell adhesion and cell recognition � Insulation � Shape and contour of body

�Protects internal organs � Electrical insulators in neurons � Helps in absorption of Fat-Soluble

�Protects internal organs � Electrical insulators in neurons � Helps in absorption of Fat-Soluble Vit � High satiety value � Palatable and tasteful

Precursor of many important physiological compounds � Sphingosine containing lipids – role in transmission

Precursor of many important physiological compounds � Sphingosine containing lipids – role in transmission of nerve impulse � Eicosanoids– role in inflammation, allergic reactions and labour � Intra-cellular messengers � Platelet-activating factor(PAF)-plasmalogen � Cardiolipin ---in mitochondria-- apoptosis

�Cholesterol---steroid hormones and Vitamin-D

�Cholesterol---steroid hormones and Vitamin-D

Relationship with the diseases �Lipids along with proteins form lipoproteins �Abnormalities of lipoproteins are

Relationship with the diseases �Lipids along with proteins form lipoproteins �Abnormalities of lipoproteins are responsible for many diseases such as atherosclerosis causing ischemic diseases. �Lack of lysosomal acid hydrolases resulting in lipid storage diseases. �Infant respiratory distress syndrome �Ganglioside M 1 act as a receptor for cholera toxin

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