LIAISON Instrument Overview The Diagnostic Specialist Contents Highlights

The Diagnostic Specialist Contents þ Highlights Main features ® Samples and Reagents ® Accessories

The Diagnostic Specialist ® LIAISON : Main features L-CS-304 -P (081222) (Rev. A) Liaison

® LIAISON : Main features “Flash” chemiluminescence detection system Paramagnetic microparticle solid phase Continuous

The Diagnostic Specialist ® LIAISON : Samples and reagents L-CS-304 -P (081222) (Rev. A)

LIAISON®: Samples and reagents Sample management þ þ Continuous loading of sample racks On

LIAISON®: Samples and reagents Reagents (1) þ Reagent Integral: typical layout Magnetic Particles Calibrators

LIAISON®: Samples and reagents Reagents (2) þ Kit configuration: ® ® Reagent Integral mini-CD

LIAISON®: Samples and reagents Reagents (3) þ On board capability: 15 integrals (1500 tests)

® LIAISON®: Samples and reagents Controls þ Characteristics and control run requirements are dependent

The ® LIAISON Diagnostic Specialist Accessories L-CS-304 -P (081222) (Rev. A) Liaison - Instrument

LIAISON® Accessories Wash/System Liquid þ Supplied as concentrated ® ® 1 L 9 L

LIAISON® Accessories Starter Reagents þ Starter 1, Starter 2 þ Primary bottles on board

LIAISON® Accessories Reaction modules þ Continuous loading ® ® 1 reaction module = 6

LIAISON® Accessories Light Check þ Required for“System Test” “SYSTEM TEST”: (daily pre-routine check) ®

Solid waste bag LIAISON® Accessories þ Collector of disposed (emptied) Reaction Modules þ Level

Cleaning Kit LIAISON® Accessories þ CLEAN Tool ® For weekly (daily) customer maintenance procedure

The Diagnostic Specialist ® LIAISON : hardware overview L-CS-304 -P (081222) (Rev. A) Liaison

LIAISON®: hardware overview Instrument tour L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview

LIAISON®: hardware overview Instrument tour Left pipettor (samples, calibrators) Right pipettor (reagents) 2 pipetting

LIAISON®: hardware overview Instrument tour Stacker (housing for Reaction Modules) L-CS-304 -P (081222) (Rev.

LIAISON®: hardware overview Instrument tour Starter box (housing for Starter 1 and Starter 2)

LIAISON®: hardware overview Instrument tour Sample area (fits 12 sample racks, each rack has

LIAISON®: hardware overview Instrument tour Reagent area (15 lanes, refrigerated) L-CS-304 -P (081222) (Rev.

LIAISON®: hardware overview Instrument tour Pipetting areas (3 areas accessible by the pipettors) L-CS-304

LIAISON®: hardware overview Instrument tour Needle wash stations (for internal/external wash) L-CS-304 -P (081222)

LIAISON®: hardware overview Instrument tour Incubator (36± 1°C, 16 slots, one reaction module each)

LIAISON®: hardware overview Instrument tour Washer (3 needles, in magnetic field) L-CS-304 -P (081222)

LIAISON®: hardware overview Instrument tour Measure chamber (Starter injection; measure) L-CS-304 -P (081222) (Rev.

LIAISON®: hardware overview Instrument tour Solid waste (emptied reaction modules) L-CS-304 -P (081222) (Rev.

LIAISON®: hardware overview Instrument tour Wash/System liquid (2 x 10 L, Double tank, sensor-controlled)

LIAISON®: hardware overview Instrument tour Liquid waste (10 L, sensor-controlled) L-CS-304 -P (081222) (Rev.

LIAISON®: hardware overview Reaction Modules from stacker to waste Wash Pip. Staker Inc. L-CS-304

The Diagnostic Specialist ® LIAISON User Interface L-CS-304 -P (081222) (Rev. A) Liaison -

LIAISON®: User Interface General characteristics þ þ þ Touch screen monitor Easy and intuitive

References LIAISON®: User Interface þ User Manual (multi-language) þ Quick Guide (multi-language) L-CS-304 -P

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® LIAISON : Instrument Overview

The Diagnostic Specialist Contents þ Highlights Main features ® Samples and Reagents ® Accessories ® þ þ Hardware overview User interface L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 2

The Diagnostic Specialist ® LIAISON : Main features L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 3

® LIAISON : Main features “Flash” chemiluminescence detection system Paramagnetic microparticle solid phase Continuous loading of samples and reagents Random access or batch mode 2 -point calibration (stability up to 4 weeks) þ Auto-dilution, auto-reflex, STAT þ Maximum throughput: ~180 results/h þ þ þ L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 4

The Diagnostic Specialist ® LIAISON : Samples and reagents L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 5

LIAISON®: Samples and reagents Sample management þ þ Continuous loading of sample racks On board capability: 144 samples Active opening flap Barcode recognition of racks and samples (compatibility with different tube diameter) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 6

LIAISON®: Samples and reagents Reagents (1) þ Reagent Integral: typical layout Magnetic Particles Calibrators Other Reagents Handle Holder Nose Aluminum Seals Stirring wheel Integral label with barcode L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 7

LIAISON®: Samples and reagents Reagents (2) þ Kit configuration: ® ® Reagent Integral mini-CD (IFU, method file) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 8

LIAISON®: Samples and reagents Reagents (3) þ On board capability: 15 integrals (1500 tests) þ Continuous loading of “reagent integrals” (recognition via barcode) þ On board refrigerated area (on-board stability up to 8 weeks) þ Active opening flap L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 9

® LIAISON®: Samples and reagents Controls þ Characteristics and control run requirements are dependent on assays þ QC software L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 10

The ® LIAISON Diagnostic Specialist Accessories L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 11

LIAISON® Accessories Wash/System Liquid þ Supplied as concentrated ® ® 1 L 9 L with distilled/deionized water Water quality requirement: “NCCLS grade III” þ Inventory controlled by sensor 1 liter L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 10 liters 12

LIAISON® Accessories Starter Reagents þ Starter 1, Starter 2 þ Primary bottles on board þ Inventory controlled by sensors L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 13

LIAISON® Accessories Reaction modules þ Continuous loading ® ® 1 reaction module = 6 cavities (6 tests) stacker capacity = 120 reaction modules (720 tests) þ Inventory controlled by sensors L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 14

LIAISON® Accessories Light Check þ Required for“System Test” “SYSTEM TEST”: (daily pre-routine check) ® ® ® L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview Priming Checking of pipetting accuracy and precision Checking of signal background and level 15

Solid waste bag LIAISON® Accessories þ Collector of disposed (emptied) Reaction Modules þ Level controlled by software counter L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 16

Cleaning Kit LIAISON® Accessories þ CLEAN Tool ® For weekly (daily) customer maintenance procedure (automated CLEAN test) þ PUMP Tool ® For monthly customer maintenance procedure L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 17

The Diagnostic Specialist ® LIAISON : hardware overview L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 18

LIAISON®: hardware overview Instrument tour L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 19

LIAISON®: hardware overview Instrument tour Left pipettor (samples, calibrators) Right pipettor (reagents) 2 pipetting needles (Teflon coated; internal and external programmable wash) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 20

LIAISON®: hardware overview Instrument tour L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 21

LIAISON®: hardware overview Instrument tour Stacker (housing for Reaction Modules) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 22

LIAISON®: hardware overview Instrument tour Starter box (housing for Starter 1 and Starter 2) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 23

LIAISON®: hardware overview Instrument tour Sample area (fits 12 sample racks, each rack has 12 available positions) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 24

LIAISON®: hardware overview Instrument tour Reagent area (15 lanes, refrigerated) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 25

LIAISON®: hardware overview Instrument tour Pipetting areas (3 areas accessible by the pipettors) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 26

LIAISON®: hardware overview Instrument tour Needle wash stations (for internal/external wash) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 27

LIAISON®: hardware overview Instrument tour Incubator (36± 1°C, 16 slots, one reaction module each) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 28

LIAISON®: hardware overview Instrument tour Washer (3 needles, in magnetic field) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 29

LIAISON®: hardware overview Instrument tour Measure chamber (Starter injection; measure) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 30

LIAISON®: hardware overview Instrument tour Solid waste (emptied reaction modules) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 31

LIAISON®: hardware overview Instrument tour Wash/System liquid (2 x 10 L, Double tank, sensor-controlled) Wash/System liquid (10 L, sensor-controlled) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 32

LIAISON®: hardware overview Instrument tour Liquid waste (10 L, sensor-controlled) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 33

LIAISON®: hardware overview Reaction Modules from stacker to waste Wash Pip. Staker Inc. L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview Pip. Meas. Waste 34

The Diagnostic Specialist ® LIAISON User Interface L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 35

LIAISON®: User Interface General characteristics þ þ þ Touch screen monitor Easy and intuitive menu-structured software Multi-language Sample result traceability (kit info, flags, etc. ) Access-right structure Flexible LIS connection L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 36

References LIAISON®: User Interface þ User Manual (multi-language) þ Quick Guide (multi-language) L-CS-304 -P (081222) (Rev. A) Liaison - Instrument Overview 37