leptospirosis Definition Leptospirosis is a bacterial disease related
leptospirosis
Definition Leptospirosis is a bacterial disease related to genus Leptospira which cause septicemia, It is rare in cats but more common in dogs, cattle Leptospirosis is a zoonotic disease (human). NB: In man: it causes Weil’s disease
pathogenesis fever Localized in g n lu liver jaundice kidne Uterus in pregnant animal abortion y br a in
Septicemia septicemia leads to petechial hemorrhages and edema on serous membranes (pleura ) may be seen in other organs as : myocardium , adrenal glands, pancreas, gallbladder and lung
Pulmonary hemorrhage
A-Canine Leptospirosis: Pathognomonic Lesions: Acute leptospirosis: Liver: Macroscopic Picture : 1 -The liver is enlarged and yellow in color. 2 -Yellow m. m. due to icterus. 3 -Peticheal hemorrhages on the pleura, pericardium and peritoneum.
Icterus
Microscopic Picture: . 1 - coagulative necrosis in hepatic cells. 2 -Dissociation of the hepatic cells (individualization). 3 -hemolytic jaundice with dilation of the bile canaliculi with yellow bile pigments. 4 -Hemosiderosis are seen in the kupffer cells.
Organ : Liver. Stain : H&E. Micro : Dissociation and individualization hepatic cells.
B- Bovine leptospirosis Subacute and Chronic leptospirosis: Macroscopic Picture: 1 -The kidneys are enlarged & atrophied (chronic). 2 -Grayish-white spots throughout the cortex (white spotted kidney) and the capsule is not easily detached. 3 -Smooth or pitted surface with hemorrhage at the corticomedullary junction. .
Microscopic Picture: 1 -Agggregations of lymphocytes 2 -Extenssive coagulative necrosis. 3 -Fibrosis and cystic dilation of some renal tubules in chronic stage. 4 -Cellular and hyaline casts
h T k n a u o y
- Slides: 16