Lecture 08 Second Messengers II Calcium signaling BIOL
Lecture 08 – Second Messengers II – Calcium signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13 F
CSB Fig 02: 01 Cell signalling pathways Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
Transducers Second Messengers II 1. • 1. Calcium signaling Cyclic ADPribose • 2. Inositol phosphate & other lipid signaling • PLC – PIP 2, DAG • PI 3 K – PIP 3 • PLD – PA
CSB Fig 2: 14 Basic Ca 2+ signalling mechanism Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 2: 15 Ca 2+ signalling dynamics Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 2: 17 Ca 2+ signalling toolkit Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 10 Ca 2+ entry mechanisms Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
ROCs • Cysteine-loop receptors • • Nicotinic acetylcholine receptors (n. ACh. Rs) 5 -Hydroxytryptamine 3 (5 -HT 3) receptors γ-Aminobutyric acid (GABA) receptors Glycine receptors (Gly. Rs) • Glutamate receptors • α-Amino-3 -hydroxy-5 -methylisoxazole-4 -propionic acid (AMPA) receptors • N-methyl-D-aspartate (NMDA) receptors • Kainate receptors • ATP-sensitive P 2 X receptors
CSB Fig 3: 11 Nicotinic acetylcholine receptor Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
ROCs • Cysteine-loop receptors • • Nicotinic acetylcholine receptors (n. ACh. Rs) 5 -Hydroxytryptamine 3 (5 -HT 3) receptors γ-Aminobutyric acid (GABA) receptors Glycine receptors (Gly. Rs) • Glutamate receptor • α-Amino-3 -hydroxy-5 -methylisoxazole-4 -propionic acid (AMPA) receptors • N-methyl-D-aspartate (NMDA) receptors • Kainate receptors • ATP-sensitive P 2 X receptors
CSB Fig 3: 13 Ionotropic glutamate receptor Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 14 AMPA receptor phosphorylation Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 15 NMDA receptor Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
ROCs • Cysteine-loop receptors • • Nicotinic acetylcholine receptors (n. ACh. Rs) 5 -Hydroxytryptamine 3 (5 -HT 3) receptors γ-Aminobutyric acid (GABA) receptors Glycine receptors (Gly. Rs) • Glutamate receptors • α-Amino-3 -hydroxy-5 -methylisoxazole-4 -propionic acid (AMPA) receptors • N-methyl-D-aspartate (NMDA) receptors • Kainate receptors • ATP-sensitive P 2 X receptors
CSB Fig 3: 16 P 2 X receptor structure Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 10 Ca 2+ entry mechanisms Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: Cyclic nucleotide-gated channels Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 10 Ca 2+ entry mechanisms Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 07 Ca. V 2 channel family Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 10 Ca 2+ entry mechanisms Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 19 Conformational coupling hypothesis Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 22 STIM-induced Ca 2+ entry Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 46 Ryanodine receptor structure Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 3: 47 Ins. P 3 R regulation Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 2: 19 Ca 2+-induced Ca 2+ release Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 2: 20 Ca 2+ transient mechanisms Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
CSB Fig 2: 21 Temporal aspects Cell Signalling Biology - Michael J. Berridge - www. cellsignallingbiology. org - 2012
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