Learning from feedback An Immune cell perspective Orchi

Learning from feedback: An Immune cell perspective Orchi Anannya Ph. D. Candidate August Lab BBS Program

Basics of the Immune System • Learning objectives • Identify the different types of immune cells • Describe with a specific example feedback between two types of immune cells • Poll everywhere • www. pollev. com/teachingpoll 817

Feedback Attack Infected Cell +

Feedback Attack Infected Cell + Attack Uninfected Cell

Feedback Attack Infected Cell + - Attack Uninfected Cell

An important immune cell – the T Cells

T Cell • Originates in Thymus • Can be CD 8 positive T cell • kills infected cells • Can be CD 4 positive T cell • helps or regulates function of other T cells T cell Receptor

T Cell CD 8 CD 4 TH 1 • CD 8 positive T cell • CD 4 positive T cell • T Helper type 1 (TH 1) • T Helper type 2 (TH 2) • T regulatory cell (Treg) CD 4 TH 2 CD 4 Treg

T Cell + • CD 8 positive T cell

T Cell + • CD 8 positive T cell • CD 4 positive T cell • T Helper type 1 (TH 1) • T Helper type 2 (TH 2) +

T Cell + • CD 8 positive T cell • CD 4 positive T cell + • T Helper type 1 (TH 1) • T Helper type 2 (TH 2) • T regulatory cell (Treg) -

Many more examples being investigated………. . • There is more to discover. . a. How does the CD 4 or CD 8 T cell know to attack the infected cell ? T reg CD 8 or CD 4

Many more examples being investigated………. . • There is more to discover. . a. How does the CD 4 or CD 8 T cell know to attack the infected cell ? b. How does Treg cells know to suppress the CD 4 or CD 8 T cell’s function ? T reg CD 8 or CD 4

Many more examples being investigated………. . • There is more to discover. . a. How does the CD 4 or CD 8 T cell know to attack the infected cell ? b. How does Treg cells know to suppress the CD 4 or CD 8 T cell’s function ? c. Does the mechanism differ depending on type of viral or bacterial infection ? T reg CD 8 or CD 4

Many more examples being investigated………. . • There is more to discover. . a. How does the CD 4 or CD 8 T cell know to attack the infected cell ? b. How does Treg cells know to suppress the CD 4 or CD 8 T cell’s function ? c. Does the mechanism differ depending on type of viral or bacterial infection ? d. What happens to the dead infected cell ? T reg CD 8 or CD 4

Many more examples being investigated………. . • There is more to discover. . a. How does the CD 4 or CD 8 T cell know to attack the infected cell ? b. How does Treg cells know to suppress the CD 4 or CD 8 T cell’s function ? c. Does the mechanism differ depending on type of viral or bacterial infection ? d. What happens to the dead infected cell ? e. What happens when you have the same viral or bacterial infection the second time ? T reg CD 8 or CD 4

Many more examples being investigated………. . • There is more to discover. . a. How does the CD 4 or CD 8 T cell know to attack the infected cell ? b. How does Treg cells know to suppress the CD 4 or CD 8 T cell’s function ? c. Does the mechanism differ depending on type of viral or bacterial infection ? d. What happens to the dead infected cell ? e. What happens when you have the same viral or bacterial infection the second time ? f. Can immune cells retain memory of primary infection ? T reg CD 8 or CD 4

Thank you for your participation Reference • Janeway’s Immunology Textbook Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5 th edition. New York: Garland Science; 2001.