LEARN ALL A A WELL THE 12 YOU
- Slides: 19
LEARN ALL A. A …WELL THE 12 YOU NEED FOR BIOL 1362 © cimmeral. wordpress. com
Zee 12 amino acids “zee” as in “the” with a bad fake French accent : ) This method involves building off of what you already know…. it’s convenient method too seeing as amino acids are the building blocks of life (depending on your perspective, of course) teehee c(: From this point on it will be known as… © cimmeral. wordpress. com
STOP PLEASE HOLD UP LET ME ROLL UP © cimmeral. wordpress. com
You MUST know this H | H 3 N+ --- COO | R © cimmeral. wordpress. com
Nonpolar, aliphatic R groups ( C & H groups) H | H 3 N+ --- COO | || CH H 23 | CH Alanine Glycine | | Ala Gly H 2 C ---- CH 2 A Proline G Pro P TIPS None of • Instead • CH Just 3 like learn it Ala, there are THREE CH 2’s © cimmeral. wordpress. com
Polar uncharged R groups Glutamine Gln Q H | H 3 N+ --- COO | H --- CH C --OH 22 OH Serine | Ser CH SH 23 Threonin S | Cysteine Thr H 2 N --- C = O Cys T C TIPS Ala BUT Pro with • Think None CHOH • with Just before 2 1 learn CH 2 it the. CH CH 2‘s, followed by 3 followed SH by • CONH Remember 2 the SH because you know that 2 Cysteines combine via a disulphide bond to form Cystine © cimmeral. wordpress. com
Aromatic R groups Phenylalanine Tyrosine Phe Tyr F Y H | H 3 N+ --- COO | CH 2 | | OH TIPS Cys with • F with ana. OH benzene ring instead of SH © cimmeral. wordpress. com
Negatively charged R groups Gluatmate Aspartate Glu Asp E D H | H 3 N+ --- COO | CH 2 | CH COO 2 | COO - TIPS • Asp Cys with 2 COOinstead CH 2‘s of SH Negatively charged R groups So remember the COO- © cimmeral. wordpress. com
Positively charged R groups Lysine Lys K H | H 3 N+ --- COO | CH 2 TIPS • Glu with 3 CH 2’s AND +NH 3 instead of COO- | CH 2 | +NH 3 Positively charged R groups So remember the +NH 3 © cimmeral. wordpress. com
! RECAP!! !!! © cimmeral. wordpress. com
NONPOLAR ALIPHATIC R GROUPS H H | | H 3 H N+N--C --COO + --C --- COO 3 | | CH 3 H R Alanine Glycine Ala A Gly STEP 2 1 H | H 3 N+ --- COO | | | CH 2 | | H 2 C ---- CH 2 - Proline Pro P G © cimmeral. wordpress. com
H POLAR | UNCHARGED STEP 3 H N --C --- COO | R GROUP CH OH 3 + Serine Ser S - 2 © cimmeral. wordpress. com
H | H 3 N+ --- COO | H --- C --- OH | CH 3 STEP 4 Threonin Thr T H H || ++--- COO- HH 3 N 3 N --- COO || CH--H --- C 3 OH Alanine | Ala CH 3 A Threonin Thr T POLAR UNCHARGED R GROUP © cimmeral. wordpress. com
H | H 3 N+ --- COO | | | CH 2 | | H 2 C ---- CH 2 Proline Pro P STEP 5 H | H 3 N+ --- COO | CH 2 | H 2 N --- C = O Glutamine , Gln, Q POLAR UNCHARGED R GROUP H | H 3 N+ --- COO | CH 2 | SH Cysteine Cys C© cimmeral. wordpress. com
H H | | - N+ --- COO H 3 | | CH 2 Cysteine CH 2 | Cys | SH c AROMATIC STEP 6 R GROUP Phenylalanine, Phe, F | OH Tyrosine, Tyr, Y © cimmeral. wordpress. com
H | H 3 N+ --- COO | CH 2 || COO CH 2 Aspartate, | Asp, D COOGlutamate, Glu, E NEGATIVELY CHARGED STEP 7 R GROUP SH COO | - Cysteine, Cys, CAsp, Aspartate, D © cimmeral. wordpress. com
H H | | H 3 N+ --- COO - H 3 N+ --- COO H | || CH CH 2 H 3 N+ --- C --- 2 COO | || | | CH 2 | | | H 2 C ---- |CH 2 Proline COO | Pro +NH P Glutamate, Glu, E 3 Lysine, Lys, K POSITIVELY CHARGED STEP 8 R GROUP © cimmeral. wordpress. com
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J Hehehe I know you’re wondering what’s going on at chimmeral. wordpress. com but I’m not gonna tell you…you’re just gonna have to go see for yourself! --- Zee ; ) © cimmeral. wordpress. com