Leadership Through Innovation TM LEADERSHIP THROUGH INNOVATION TM

Leadership Through Innovation TM LEADERSHIP THROUGH INNOVATION TM Leadership Through Innovation TM Nevro 1

Nevro: Advancing Spinal Cord Stimulation Leadership Through Innovation TM Novel Rechargeable Spinal Cord Stimulator Implantable device placed minimally invasively by Pain Specialists and Spine Surgeons Unique high-frequency waveform up to 10 k. Hz Anatomic lead placement without paresthesia mapping The Senza® System is an investigational device in the U. S. Leadership Through Innovation TM Nevro 2

Company Milestones Leadership Through Innovation TM 2006 2007 2008 2009 2010 2011 2012 IDE initiated US IP issued European launch International pivotal clinical Pilot short term testing in US study Early external prototype testing Validation in additional large animal model: UC Davis Animal work: Stanford University Founded at Mayo: Initial idea generation roundtable Leadership Through Innovation TM Nevro 3

US Senza-RCT Study Underway Leadership Through Innovation TM Negotiated with the FDA First study to compare SCS device systems Non-inferiority study on safety and efficacy Largest randomized SCS study ever conducted Senza compared to commercially available SCS The Senza® System is an investigational device in the U. S. Leadership Through Innovation TM Nevro 4

Safety and Effectiveness Endpoints Leadership Through Innovation TM Primary Non-inferiority comparison: change in back pain VAS and neurological status from baseline • Assessments such as Secondary • % change in back pain, leg pain, function • Adverse event rates • Paresthesia perception Tertiary • Includes sleep quality, quality of life, depression level, pain med usage The Senza® System is an investigational device in the U. S. Leadership Through Innovation TM Nevro 5

Pain Gaining Recognition as a Challenge Leadership Through Innovation TM Nevro 6

Opportunity for SCS Community Leadership Through Innovation TM Physical therapy & conservative therapies Interventional techniques (i. e. blocks) Leadership Through Innovation TM SCS Expansion Opportunity Spine surgery Nevro Oral opioids Spinal cord stimulation Drug Pumps 7

Difficult Funding Environment for Innovation Leadership Through Innovation TM Nevro 8

Opportunity for Neuromodulation Leadership Through Innovation TM Significant opportunity for neuromodulation to improve healthcare To accomplish this, additional effort needed in: Clinical Evidence Education for HCP and Payers Leadership Through Innovation TM Nevro Patient Experience 9