LDLP LDL Particle Number The total number of

LDL-P (LDL Particle Number) ► The total number of LDL particles in nanomoles per liter 1 nmol/L = 6 X 1014 particles/L or Under 1000 -1299 1300 -1599 ► 600, 000, 000 (six hundred 1600 -2000 trillion) LDLs > 2000 High there would Borderline Very Optimal Near ► Thus with an ideal LDL-P value of 1000 nmol/L be High Optimal ► 600, 000, 000 (6 X 1017) or six hundred quadrillion LDLs ► per liter ► In 2. 7 liters of plasma nanomols/Liter (normal plasma volume) there would be ► 600 quadrillion X 2. 7 – or put another way: ► ~16 x 1018 circulating particles or ► 16, 000, 000 (1. 6 quintillion LDL particles)

Cholesterol Molecules Per LDL Particle ►Estimates of the cholesterol content of the LDL particles of individual subjects were obtained by dividing LDL-C (in mmol/L units), by LDL-P (nmol/L). ►To calculate the approximate number of cholesterol molecules per LDL particle use the following formula: Cholesterol Molecules = per LDL Particle LDL-C (mol/L) LDL-P (mol/L) To convert mg to mols: multiply the mg/d. L mass concentrations by 0. 0259 mmol = 10 -3 mol nmol = 10 -9 mol Cromwell W et al. J Clin Lipidol 2007; 1: 583 -592

Cholesterol Molecules per Particle Cholesterol Molecules = per LDL Particle Case A LDL-C (mol/L) LDL-P (mol/L) Case B LDL-C of 101 mg/d. L = 2. 61 millimol/L LDL-C of 65 mg/d. L = 1. 69 millimol/L 2. 61 mmol/L = 0. 00261 mol/L 1. 69 mmol/L = 0. 00169 mol/L LDL-P of 1428 nmol/L = 0. 000001428 mol/L LDL-P of 1647 nmol/L = 0. 000001647 mol/L 0. 00261 mol/L / 000001428 mol/L 1864 cholesterol molecules per particle 0. 0016900 mol/L /. 000001647 mol/L 1056 cholesterol molecules per particle Dayspring T et al. Research Reports in Clinical Cardiology 2010; 1: 1 -10

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