LCMS Chromatography Systems 212 LC The Complete Solution

LC/MS Chromatography Systems 212 -LC

The Complete Solution Varian LC components, pumps, autosamplers and the New MS Workstation SW (V 6. 6) can be used to create a complete configuration, allowing full control of the Varian LC/MS system 2

The Complete Solution Software MS Workstation Software • Single point control of modules and accessories • Effortless detector optimisation and control • Simple navigation while reviewing and processing results • Network compatibility for file management, printing and remote access • Extensive reporting for complete analyses • Fully integrated 212 -LC command control driver 3

The Complete Solution Autosamplers Productivity increases with automation of sample injections. A range of modules are offered to suit various throughput needs • HTS PAL is a low loss, high speed, high capacity, robust autosampler offering outstanding flexibility and productivity • Pro. Star 430 is a precise, versatile autosampler delivering reliable results, particularly for limited sample volumes • Pro. Star 410 is an economical, versitle and easy to use autosampler that is suited to research use, but rugged enough for routing QC work. 4

The Complete Solution HPLC Columns Varian offers a variety of high quality columns and media for sample prep to analytical and on to preparative applications. • Polaris columns provide unique bonded phases to maximize polar retention and selectivity, while virtually eliminating silonol activity. Polaris sets new standards for peak symmetry, selectivity and reproducibility • Pursuit diphenyl columns deliver fast separations without sacrificing resolution. Moving from analytical development to production – Pursuit materials meet requirements for analytical resolution and high quality prep 5

The Complete Solution HPLC Detectors Several Varian HPLC detectors are useful for LC/MS applications • PDA and UV/Vis offer easy offline methods development and trouble shooting for separations • ELSD adds an additional “universal” detection channel to the MS data, finding hidden peaks and giving additional quantitative insights 6

The Complete Solution Chromatograph Pumps 212 -LC Chromatography pump To meet the flow requirements of modern LC/MS the use of a binary, low delay volume, high pressure mixing system is essential. The 212 -LC pumping system has the ability to meet your needs from fast 4. 6 mm columns down to 2 mm columns for bioseparations. • • • 7 Quality gradient or blending separations up to 2 m. L/min. With excellent accuracy and stability for compositional, flow and pressure Reliable performance for LC/MS is essential. The mechanical design from the mechanism to no-prime check valves is designed for years of reliable use. Fully integrated software control under MS Workstation assures complete LC/MS control and data storage

The Complete Solution LC Performance – Low Delay Volume Low delay volume means effective 200 µL/min gradient runs 8 Parabens (Methy, Ethyl, Propyl, Butyl) five minute gradient run, great precision and fast gradient results with little delay volume

The Complete Solution LC performance – Compositional Precision Fine precision of flow and composition make for better peak ID, retention time accuracy and quantitative quality 10% steps, far less than 1% ripple and accuracy values, 200 µL/min 9

Performance at a Competitive Price High Performance Target Position 10 Mid Performance Low Performance List Price

The Complete Solution Benefit Bundles: Understanding what customers value Academia Performance Purchase Price Environmental Total Cost of Ownership Uptime Pharma/Biotech Performance Quality/Uptime LC/MS Benefit Bundles Toxicology Credibility Quality/Uptime Food/Ag Performance Initial Cost/TCO Chem/Materials Performance Quality/Uptime 11

The Complete Solution Benefits Performance • State of Play performance for analytical columns Quality and Uptime • Modern, conventional reciprocating design for rugged reliable operation Purchase Price • Strong value for performance, small percentage of the LC/MS package price Cost of Ownership • ability to run low flows reduces solvent and waste disposal costs Credibility • Industry standard specifications and performance allows the focus to move to MS benefits and advantages 12

The Complete Solution 212 -LC Ordering Information • 0391180001 212 -LC – includes 150 µL gradient mixer, heads, plumbing and cables for MS workstation control • Optional Degas strongly recommended for Gradient work – A 6313 (4 channel, 1 m. L/min) • Optional mixers are available on the price list Requires MS workstation 6. 6 or higher 13

The Complete Solution Pricing • Two head design with higher performance and lower delay volume than the 210 series – commands an increased value-price • Minor part of the LC/MS system pricing • 212 -LC price is complete – an assembled and working pump for the MS • Pricing on SAP or from local sales managers, approximately 20% increase from 210 s 14

Questions Can I convert my existing order ? • Shipment: immediately – Only orders with LC/MS will be filled in Q 4 – Solo 212 -LC orders (for existing MS systems) will ship in Q 1 FY 07 • New orders should be quoted with 212 -LC • If the modules have not been shipped or built, changes can be processed with the associated pricing changes • Other ? 15

16