Lay S 38 Lay S 39 Lay S

Lay. S 38 Lay. S 39 Lay. S 40 Lay. S 41 Lay. S 42 Lay. S 44 Lay. S 45 Lay. S 46 Lay. S 47 Lulo. RGD MNKIILLSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFPALVFCAE------AMPKESVNILNTENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFLALVFCAE------AMPKESANILNAENEPDDTVDIDEGLPDAFEEDYE MNKIILFSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFEEDYE MNKIILFSAVFLALVFCAE------AMPRESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILFSAVFVALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MNKIILLSAVFLALVFCAE------AMPKESVNILNAENEPDDTVDIDEGLPDAFDEDYE MKLFCLIFVVFVALEVCIETVKAMEATEEISVKLQDDANEPDDSLDLDEGLPDAFDEDYN * * -QDGHNPYPCRGDC--- -RDGHNPYPCRGDC--- -QDGHNPYPCRGDC--- NQAEYKPNP-RGDYRRR 54 54 54 60 67 67 67 76 Fig. S 1

Lay. S 48 Lay. S 49 Lay. S 50 Lay. S 51 Lay. S 52 Lay. S 53 Lay. S 54 Lay. S 55 Lay. S 56 Lay. S 58 Lay. S 59 Lay. S 60 Lay. S 61 Lay. S 62 Lay. S 63 Lay. S 64 Lay. S 65 Lay. S 66 Lay. S 67 Lay. S 68 Lay. S 69 Lay. S 70 Lay. S 71 Lay. S 72 Lulo. SL 1 * * MKYQCFVLIAIFFWIGQSRAE NPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCIL RCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE NPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFR GVLISYNAVPGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYPCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV SGNEKNKLFDHIKACA MKCQCFVLIAIFFWIGQSRAE RPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKKKLFDHIKACA MKYPCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE NPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV LGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE NPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE NPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV SGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE NPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE NPEERCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLLDHIKACA MKYQCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE NPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCILHCSYSYYGFTDEN CRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGRSRAENPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE NPEEKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV LGNEKNKLFDHIKACA MKYQCFVLIAIFFWIGQSRAE HPERKCIRELARTDEVCILHCSYSYYGFTDENYRITKKHIETFRDVLISYNAV PGNEKNKLLDHIKACA MNHLCFIIIALFFLVQQSLAEHPEEKCIRELARTDENCILHCTYSYYGFVDKNFRIAKKHVQKFKKILVTFDAVPKKEKKKLLEHIEACA * * DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DV DTANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DA DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DV DTANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK NV DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DV DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK NV DTANATKPKSHNDKCYKIIHYYRCVVDGK ILSWNSYAAAIIKYDKTK DV DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK NV DTANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DV DAANATKPKSHNDKCYKIIHYYRCVVDGK ILSWNSYAAAIIKYDKTK NV DAANATKPKSHNDKCYKIIHY CRCVVDGKILSWNSYAAAIIKYDKTK NV DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DV DAANATKPKSHNDKCYKIIHYYRCVVDGK ILSWNSYAAAIIKYDKTK NV DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DV DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK NV DTANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DV DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK NV DAANATKPKSHNDKCYKIIHYYRCVVDGK VLSWNSYAAAIIKYDKTK DV DSANADQPQTKDEKCTKINKYYRCVVDGKILPWNSYADAIIKFDKTLNV 90 90 90 90 90 90 90 139 139 139 139 139 139 139 Fig. S 2

Lay. S 32 Lay. S 33 Lay. S 34 Lay. S 36 Lay. S 37 Ppe. SP 09 * * * MSFLFFLVVLISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITD 60 MSFLFFLVALISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITD 60 MSFLFFLVVLISIGLWVGPCVADNPENRCIKQFAKTNPACIVHCKYNLYKFTDDNYDITD 60 M--NYFVAVLISAVFLARSCQGDHPEAKCIRDFKDKNPACIIHCKYNFYKFTDDKFSINE 58 * * * Lay. S 32 QHINKFTDILIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLI 120 Lay. S 33 QHINKFTDVLIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLI 120 Lay. S 34 QHINKFTDILIKNKAVDGSKKSQVQEHLKKCTEESLKKTHGKNCQRLVEYYSCAVDNKLI 120 Lay. S 36 QHINKFTDVLIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLI 120 Lay. S 37 QHINKFTDVLIKNKAVDGSKKSQVQEHLKKCAEESLKKTHGKNCQRLVEYYSCAVDNKLI 120 Ppe. SP 09 EHMRKLTDILIKYKAVDAAEKARVEKHLRKCKEEATQKSKTPSCERILYYYSCLVDLRLI 118 Lay. S 32 DYFKYESAINSYDRTIYTPPYSG 143 Lay. S 33 DYFKYESAINSYDRSIYTPPYSG 143 Lay. S 34 DYFKYESAINSYDRTIYTPPYSG 143 Lay. S 36 DYFKYESAINSYDRTIYTPPYSG 143 Lay. S 37 DYFKYESAINSYDRSIYTPPYSG 143 Ppe. SP 09 DYYKYNDAMKTYDNTIYLSRFSN 141 Fig. S 3

A Lay. S 22 Lay. S 23 Lay. S 24 LJM 11 MKLFLLVFTGILFQGILGVEITQGYKWRQILYGDVTPGTYNPDTNIPTAFAHDADGHKLFLTIPRKFPKIPHTLAEVDTEKNPGVSGKRS 90 MKLFLLVFTGILFQGILGVEITQGYKWRQILYGDVTPGTYNPDTNIPTAFAHDADGHKLFLTIPRKFPKIPYTLAEVDTEKNPGVSGKRS 90 MKVFFSIFTLVLFQGTLGAD-TQGYKWKQLLYNNVTPGSYNPDNMISTAFAYDAEGEKLFLAVPRKLPRVPYTLAEVDTKNSLGVKGKHS 90 * PLLNRFSGHKSGNELTSVYQPVIDDCRRLWVVDVGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRHHFPVRLVEKPTYFGGFAVDV 180 PLLNRFSGHKSGKELTSVYQPVIDDCRRLWVVDVGSVEYRSRSAKDYPSHRPAIVAYDLKQPNYPEVVRYHFPVRLVEKPTYFGGFAVDV 180 PLLNRFSGHKSGKELTSVYQPVIDDCRRLWVVDVGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRYHFPVRLVEKPTYFGGFAVDV 180 PLLNKFSGHKTGKELTSIYQPVIDDCRRLWVVDIGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRYYFPTRLVEKPTYFGGFAVDV 180 * VNPTGDCSETYVYITNFLSNALFIYDHKNQQSWNVTDATFKAERPSTFDHQGKQYTYKAGLFGITLGDRDKDGNRPAYYLAGSSIKVYSV 270 ANPKGDCSETFVYITNFLRGALFIYDHKKQDSWNVTHPTFKAERPTKFDYGGKEYEFKAGIFGITLGDRDSEGNRPAYYLAGSAIKVYSV 270 * NTKELKQKNKKLNPELLGNRGKLNDAIALAYDPKTKGIFFAESKTRQVSCWNTQKMPLRMQHTDVIYSNTRFVFGTDISVDSKGTLWFMS 360 NTKELKQKNKKLNPELLGNRGKLNDAIALAYDPKTKVIFFAESNTRQVSCWNTQKMPLRMQHTDVIYSNTRFVFGTDISVDSKGTLWFMS 360 NTKELKQKGGKLNPELLGNRGKYNDAIALAYDPKTKVIFFAEANTKQVSCWNTQKMPLRMKNTDVVYTSSRFVFGTDISVD----- 350 * NGFPPVKNSQKFKFDYPRYRLLNVDTQAAIAGTNCEIKPR 400 -------------------- 350 B Lay. S 118 LJM 17 90 90 * 177 180 * * * 266 270 356 360 405 412 Fig. S 4

Lay. S 8 Lay. S 9 Lay. S 10 Lay. S 11 Lay. S 12 Lay. S 13 Lay. S 14 Lay. S 16 Lay. S 17 Lay. S 18 Lay. S 19 Lay. S 20 Lay. S 21 Lulo. APY MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMD KKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MLLKLWIFTMATFLLVQVSKSAPPGVEWYHFGLIADMD KKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVGKSAPPGVEWYHFGLIADMD KKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLRIFTLATALLVQVSKSAPPGVEWYHFGLIADMD NKAITPSDRNTFNTILNIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMD KKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMD KKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMD KKSISPNDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKLWIFTLATFLLVQVSKSAPPGVEWYHFGLIADMD KKSISPSDRNTFNSILKIDELRHNTRTGRYNFVISRVKKPVSTRFGYKGRGA MFLKWVVCAFATVFLVGVSQAAPPGVEWYHFGLIADMD KKSIA-SDKTTFNSVLKIDELRHNTKTDQYIYVRSRVKKPVSTRYGFKGRGA ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKYDKIYAGSTGITFKDEKGNANTQSLWVKEITKGG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFNAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRTTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLSNGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVEEITKDG ELSEILVFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWAKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKRPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVNEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVRNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFDKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEILIFNKQLYTFDDKTGIVFRMTKDGKLIPWVVLANGDGKQPDGFKAEWATVKNDKIYVGSTGITFKDEKGNANTQSLWVKEITKDG ELSEIVVFNNKLYTVDDKSGITFRITKDGKLFPWVILADADGQRPDGFKGEWATIKDDTIYVGSTGMLK-------FTSSLWVKKITKDG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEKGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPKQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVKDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEKGFVWHEAVIWSQIRKEWIFLPGKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEQGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG SVTSHDWSQKYKKIREAMKLPEKGFVWHEAVIWSQIRKEWIFLPRKCSHLAFTPSSEEASGCNLIITADEKFQNIKVIPVRDHPAEIASG VVTSHDWTDKYRKILKALNMPN-GFVWHEAVTWSPFRKQWVFMPRKCSRHPFSQELEERTGCNKIVTADENFNDIQVIHIQDQPYNLASG FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGSQKK------ FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGVKKNKFD---- FPAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGVRKNKFRLKKLNLKK FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGVKKNKFD---- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGIPFFWGNQKNKFH---- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYERVAFFGGSQEK------ FSAFKFIPGQNNEKLLALRTIEQGDKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGVKKNKFD---- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYERIPFFWGSQKNKVRLKD----- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPEPKLYDEKYEGVAFFGGSQKK------ FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYNEKYEGVAFFRGNQKK------ FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPEAKLYDEKYEGVAFFGGIKKNKSD---- FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVVIDMEGNVLMPERKLYDEKYEGVAFFGGSQEK------ FSAFKFIPGTNNEKLLALRTIEQGEKIATYAVIIDMEGNVLMPERKLYDEKYERVAFFGGSQEK-----FSSFRFIPGTKNERLLALRTVEQEDQVKTWAVVMDMKGTVLMYEKELYDEKFEGLAFFGGIKKN------ 90 90 90 90 180 180 180 180 172 270 270 270 270 261 334 337 345 337 334 337 340 334 337 334 325 Fig. S 5

* * * MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF 90 MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASEETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF 90 MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF 90 MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPSSDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF 90 MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASEETDCYVKCVWKNLGSYNDADDSIKIEAIAQQF 90 MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPASDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF 90 MNVLLKIATFLCLCELGYSWQYPRNADQTLWAFKTCQREAKDQKFLEKWKKWELPVSDETYCYVKCVWKNLGSYNDADNSIKIEAIAQQF 90 MNALFLLCVLLSLGELGYSWQYPRNADQTLWAFRSCQREGKNPDLVKKWMNWELPNDRETHCYVKCVWIHLGSYNHNKHSIKIDKVKNQF 90 * * RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Lay. S 95 RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Lay. S 96 RSRGLNVPASLQKVAGPTSGSCKDVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Lay. S 97 RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Lay. S 98 RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Lay. S 99 Lay. S 100 RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Lay. S 101 RSRGLNVPTSLQKVAGPTSGSCKDVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Lay. S 102 RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Lay. S 103 RSRGLNVPASLQKVAGPTSGSCKEVYQKTIKFFLEQKANIQHAYYGTKAESDKWFAAHPETKPKGVKISQFCKGKEKSG-----CKHYCS 175 Ppe. SP 04 b SSRGVQIPPELEKIGGPTSGSCKDVYDKTIAFFKSQKTNLQKAYYGTKEDSNKWYSENPDTKPKGTKISVFCKDKNREGGKEGTCKHSCS 180 * * * MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY Lay. S 95 247 MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY Lay. S 96 247 MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY Lay. S 97 247 MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY Lay. S 98 247 MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY Lay. S 99 247 Lay. S 100 MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY 247 Lay. S 101 MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY 247 Lay. S 102 MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY 247 Lay. S 103 MYYFRLVDEDNLVVPFRKLPGYPEPKLQECRNKARATTGCKVADVLYECLKRDFPTYLSMILQNYDNESEYY 247 Ppe. SP 04 b MYYYRLVDEDNLVIPFRKLPGISESDLKECRDAASKKTGCKVADEIYECLHNVNRKGFEDALKKLDGESAVY 252 Lay. S 95 Lay. S 96 Lay. S 97 Lay. S 98 Lay. S 99 Lay. S 100 Lay. S 101 Lay. S 102 Lay. S 103 Ppe. SP 04 b Fig. S 6

Lay. S 83 Lay. S 84 Lay. S 85 Lay. S 86 Lay. S 87 Lay. S 89 Lay. S 90 Lay. S 91 Lay. S 92 Lay. S 93 Lulo 29. 2 k. Da MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDNS--DVYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGS MLKEIFFLALLVAVAQCANEIPINQQGKNYP-PIADPDKS--DDYFDDRFYSDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPVAAPGGARLGAGGT MLKEIFFLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MLKEIFVLALLVAVAQCANEIPINQQGKNYPLPIADPDKS--DDYFDDRFYPDINDESIVEAPKDNRGKPGGGSKPAAAPGGARLGAGGT MIKEVFSLALLVALAQCANEIPINRQGKDYPVPIIDPNKSSSDDYFDDRFYPDIDDEGIAEAPKDNRGKSRGGGAAGAREG--RLGTNGA TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG---- TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGRTRQGGGASRPAQG---- TPGRGATTPGGGGTRPAAGGTKPSASGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG---- TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGG-------GTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG---- TPG-------GGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG-------- TPGRGATTPGGGGTRPAAGGTRPSASGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG---- TPGRGATTPGGGGTRPAAGGTRPSAGGSRQNTGRTRPAAGGTRRGQGGTRADQGRQRPG-----NNQGGTRQGGGASRPAQG---- KPGQGGTRPGQGGTRPGQGGTRPGQGRTKPAQGTTRPAQGTRNPGSVGTKEAQDASKQGQGKRRPGQVGGKRPGQA ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIIDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEVIDGDPSGLGLAVQTI ---AAGGRKQGAKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI ---AAGGRKQGAKGTKGANRRSDLSKYKDFPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVPTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEHTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIIDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKNSPAKYIFKSPSFNEEGKTPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI ---AAGGRKQGTKGTKGANRRSDLSKYKDSPAKYIFKSPSFNEEGKIPIVNYFKTSKKEYTAAGGGPNDEYVLEIVDGDPSGLGLAVQTI NAPNAGTRKQ-QKGSRGVGR-PDLSRYKDAPAKFVFKSPDFSGEGKTPTVNYFRTKKKEHIVTRGSPNDEFVLEILDGDPTGLGLKSETI GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDSRLILENPKGNNIVGRVKIYRGAYTG GKDSRLILKIPKGTTLWAV----- GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDSRLILKNPKGNNIVGRVKIYRDAYTG GKDSRLILKNPKGNNIVGRVKIYRGAYTG GKDTRLVLENPNGNSIVARVKIYKNGYSG 88 88 88 87 88 88 165 165 164 158 158 165 165 178 252 252 251 245 245 252 252 266 281 281 270 274 274 281 281 295 Fig. S 7

* * MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMDKKNKNLLVKIHNRLRDRFAKGAVPGFQSA 89 MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKSKNLLVKIHNRLRDRFAKGAVPGFQSA 89 MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQSAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA 89 MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA 89 MLQIKQILVYLVVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA 89 MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNLLVKIHNRLRDRFAKGAVPGFQSA 89 MLQIKQILVYLAVIVAVQAQD-YCKQESCSSSGVAKPHIGCKNNGQFAQTCPKDAEIIPMNKKNKNPLVKIHNRLRDRFAKGAVPGFQSA 89 MLQIKHLLIFVGLLVVVNAQSNYCKQESCSSGGVERPHIGCKNSGDFSETCSGDAEIVKMDKKKQNLLVKMHNRLRDRFARGAVPGFAPA 90 * * Lay. S 73 AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQVMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK 179 Lay. S 74 AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK 179 Lay. S 75 AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTEDYVGGPGAGGK 179 Lay. S 76 AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK 179 Lay. S 77 AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK 179 Lay. S 78 AKMPMLKWNDGLAKLEEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTGNYVGGPGAGGK 179 Lay. S 79 AKIPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK 179 Lay. S 80 AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK 179 Lay. S 81 AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRATNICPYAGQNLAQMMSSPTHRDLNYVIKNLTREWFWEFRWAQQSHTENYVGGPGAGGK 179 Lulo Ag 5 AKMPMLKWNDELAKLAEYNVRTCKFAHDKCRAIDVCPYAGQNLAQMMSYPTHRDLNYVLKNLTREWFWEYRWAKQSQLDNYVGGPGKDNK 180 * * * Lay. S 73 QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG 270 Lay. S 74 QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNCCYTNMLKEKIYTKGKPCSECQSKKCGPVYRNLCDPSEKVDPTPDVLKQWKQQG 270 Lay. S 75 QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG 270 Lay. S 76 QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGRPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG 270 Lay. S 77 QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLRDPSEKVDPTPDVLKQWKQQG 270 Lay. S 78 QIGHFTAFIHEKSDKVGCALARFTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG 270 Lay. S 79 QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG 270 Lay. S 80 QIGHFTAFIHEQSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG 270 Lay. S 81 QIGHFTAFIHEKSDKVGCALARYTNQHNFKETLLACNYCYTNMLKEKIYTKGKPCSECQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKQQG 270 Lulo Ag 5 QIGHFTAFVHEKTDKVGCAIARFTNEHNFKETLLACNYCYTNMMKERIYTQGKPCSQCQSKKCGPVYKNLCDPSEKVDPTPDVLKQWKHGK 271 Lay. S 73 Lay. S 74 Lay. S 75 Lay. S 76 Lay. S 77 Lay. S 78 Lay. S 79 Lay. S 80 Lay. S 81 Lulo Ag 5 Fig. S 8

Lay. S 120 Lay. S 121 Lay. S 122 Lay. S 123 Lay. S 124 Lay. S 125 Lay. S 126 Lay. S 127 Lay. S 128 Lay. S 129 Lay. S 130 Lay. S 131 Lay. S 132 Lulo 16. 5 k. Da MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKCNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWMGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSETFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVFKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHLLAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLSLTFLTLRTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHLLAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNTYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MANHFFAFLCLTFLTLCTAENFVVRKLSSGKVIYVSKTFLSWYDALDFCNKYNLSLVSINSAKENTELAKTIRP--ILPE-NEVHVWIGG MNLHLAIILFVSYFTLITATDLIEKELSDCKKIFISKAELTWFQALDFCTEQNLTLLSIKSARENDEVTKAVRAEVHLPDTKKSHIWLGG * * * YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPDN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATNKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEVYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFRDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC YKFQDENGENSQRWVNGGRNVT---YTNWSSGEPNN-ANGREYCLEIYYRQYRGATDKWNDRFCTDKHPFVCERKC IRYDQ---DKDFRWISDGTTVTKTVYINWYQGEPNGGRYQKEFCMELYFKTPAG---QWNDDICTAKHHFICQEKK 87 87 87 87 90 159 159 159 159 160 Fig. S 9

Lay. S 4 Lay. S 5 Lay. S 6 Lay. S 7 Lulo 9 k. Da MNKIILISLALAVLGLCIQAKPRDTVQTLDYEDFIAAYIQRQNANDVRNKRGLEKAIASF 60 MNKIILISLALAVLVLCIQAKPRDTVQTLDYEDFIAAYIQRQNANDVRNKRGLEKAIARF 60 MNKIILISLALAVLVLCIQAKPRGTVQTLDYEDFIAAYIQRQNANDVRNKRGLEKAIASF 60 MRNFAVVSLAVAVLLFCAWP----INAED-------NEEVGKAREKRGLKDAMEHF 45 TDGFKELIKFELPKFNLPKISGLPGSSGSSDGSSGSSDGSSG-------GGSD 113 TDGFKVLIKFELPKFNLPKIPGLPGSSGSSDGSSGSSDGSSGGGPD 120 TDGFKELIKFELPKFNLPKIPGLPGSSGSSDGSSGSSDGSSG-------GGSD 113 TDGFKELIKFELPKFNLPKIPGLPGSSGSSDGSSGSS-------DGSSG-------GGSD 106 KNGFKELTK----DFKLPSLPSLPGFGKKPE--SGSSEDSGDKTEDTSG------ 88 NSKGDSEKSKEQKKD 128 NSKGDSEKSKEQKKD 135 NSKGDSEKSKEQKKD 128 NSKGDSEKSKEQKKD 121 -SKDDQSKDNTVEES 102 Fig. S 10