Lateral Inhibition How does it work Each receptor

Lateral Inhibition: How does it work? Each receptor (R) actives 1 bipolar (B) & 1 horizontal (H) cell. Each horizontal cell inhibits own bipolar and each neighboring bipolar cell. The “net” output of the bipolar cell to the ganglion cell (G) determines the signal to the brain. R R H H B G H B R R H B G G -1 +0 -2 +5 R R H B G -3 +5 R R H B B G G G -2 +5 -1 +0 -1

Lateral Inhibition: Rules: Excitation (+5) is greater than inhibition (-1). EQUAL LIGHT STIMULATION R R H H B G H B R R H B G G -1 +0 -2 +5 R R H B G -3 +5 R R H B B G G G -2 +5 -1 +0 -1

Lateral Inhibition: Calculate the inhibitory and excitatory inputs to the bipolar cells in the boxes at the bottom. EQUAL LIGHT STIMULATION R R H H B R R H B G G G 0 -1 +0 -2 +5 R R H B G -3 +5 R R H B B G G G -2 +5 -1 +0 -01

Lateral Inhibition: The net output to the ganglion cells has an enhanced signal at the borders. EQUAL LIGHT STIMULATION R R H H B R R H B G G G 0 -1 -1+0 -23+5 R R H B G -32+5 R R H B B G G G -23+5 -1 -1+0 - -1 01

Lateral Inhibition: Try it yourself: Try different patterns and intensities of light activation. R R H H B G H B R R H B G G -1 +0 -2 +5 R R H B G -3 +5 R R H B B G G G -2 +5 -1 +0 -1