Konsep Pemanfaatan Obat Tradisional dari Tradisional menuju Biomolekular

Konsep & Pemanfaatan Obat Tradisional dari Tradisional menuju Biomolekular Amarullah H. Siregar RAKERKESNAS 2019 ICE Serpong 01 - 03 Maret

Risk

Life Extension Magazine April 2015 UPDATED REPORT The Beginning Of The End Of The War On Medicine By Charles K. Bens, Ph. D For nearly 100 years, there has been a serious war going on between the proponents of allopathic (conventional) medicine and those who support natural or functional medicine. Evidence has been mounting that the conventional medical model was simply not working. Conventional medicine’s house of cards is about to begin its BIG FALL

One size Fits all Personalized Medicine Fragmented, one way Integrated Provider centric Patient centric Hospital based Community based Specialized Collaborative Procedures based Outcomes based Treating Recuperating

NEW PARADIGM IN MEDICINE DISEASE Multiple medications Poor Quality of Life Potential becomes limited Body has limited function DIS-EASE Symptoms Drug therapy Surgery Losing normal function AVERAGE No symptoms Nutrition inconsistent Exercises sporadic Health is low priority GOOD Regular exercise Good nutrition Health conscious Minimal nerve interference OPTIMAL Revitalize function Active participation Wellness lifestyle Continuous development

APPLICATION PRACTICE - More than just the absence of disease - Be in good health and truly well - Sense of vitality of body, mind and spirit RESILIENCE TO ILLNESS DIS-EASE vs DISEASE If you are ill, treatments is important but don’t stop at the neutral point

MEDICINE TODAY

THE HEALING POWER OF NATURE “There is not a disease for which nature doesn’t have a remedy right next to it” CONVENTIONAL MEDICINE Iatrogenic NATUROPATHIC MEDICINE Systematic Non Invasive Multi disciplinary No Chemical NATURAL CONCEPT MODERN MEDICINE Holistic Mother Nature

DEATH BY MEDICINE iatrogenic

MEDICINE TODAY CONVENTIONAL DISEASE SAKIT Pathogenese DISEASE SEHAT Physiogenese NON CONVENTIONAL ♣ Naturopathic Medicine ♣ Anti Aging Medicine ♣ Wellness Medicine ♣ Regenerative Medicine ♣ Functional Medicine ♣ Restorative Medicine

KONSEP SEHAT - SAKIT NENEK MOYANG INDONESIA Survey & Literature research AHS 2012 -2014 Sehat – Sakit ≈ RESILIENSI Alam ≈ KOMPONEN ENERGI VITAL FORCE Sisi SEHAT vs Sisi SAKIT Subjectivity ILLNESS Inter-Subjectivity SICKNESS Objectivity DISEASE

PHYSIOGENESIS TARGET PHYSIOGENESIS vs PATOGENESIS Dis-ease vs Disease Heal not Cure

HEALTH & MEDICAL CARE GRADING • TREATMENT • RECOVERY • REJUVENATION • REVITALIZATION • RECUPERATION

Man and Nature were interdependent 1. 2. 3. 4. 5. Only nature heals Let food be your medicine Disease is an expression of purification All disease is one It is more important what sort of person has a disease than what sort of disease a person has

Asclepios (3000 BC) Father of Ancient Medicine Rudolf Fritz Weiss Father of Folk Medicine (1895 -1992)

Functional Medicine Physiogenesis FOOD SOURCES NUTRACEUTICAL NUTRIGENOMIC BIONUTRITION ORTHOMOLECULAR STEM ENHANCER NON FOOD SOURCES PHYTOCEUTICAL PHYTOGENOMIC ESSENTIAL OILS PHYTOSTEMCEUTICAL

PRACTICAL PHYLOSOPHY Foundation Material Manpower ♣ STRUCTURAL THERAPY ≈ bio-mechanic therapy → anatomical foundation → emotional harmony ♣ BIO CHEMICAL THERAPY substances ≈ biological function → synergistic effect → enhance receptor ♣ BIOLOGICAL THERAPY right substances ≈ problems → physiological balances → stimulate, detoxify &

PRACTICAL PHYLOSOPHY Power Architect ♣ ENERGETIC THERAPY transform bio-information translate bio-energy → substitute deficiencies → adjustment excessive ♣ CHANGING PATTERN individual blue print → character & constitutional → cellular function

WELLNESS ORIENTED HOLISTIC PROGRAM THROUGH WELLBEING

WORLD HEALTH ORGANIZATION Executive Board 117 th Session January 2006 6. In cases where medicines are needed where significant numbers of pat higher incomes, there is disproportionate emphasis on products that d incremental benefits over existing ones. A breakdown of the 1, 035 new approved by the US FDA (Federal Drug Administration) between 1989 a revealed that more than ¾ are classed as having no therapeutic benefit products, so called ‘me too’ drugs (NIHCM 2002). At the same time it wa less than 1% addressed diseases that primarily afflict the poor and for w treatments would have the greatest effect on world healthcare (WHO 20

WORLD HEALTH APPROACH Alma Ata Declaration Developing Developed Relies heavily Begun to turn Plant-based medicine NUTRACEUTICAL (BIO MEDICINE)

Signal transduction Y Receptors Y Y Electron transport DNA - Replication - Transcription - DNA repair Transporter Ion channels Protein biosynthesis Mitochondrion n u c l e u s Enzymes RNA lysosome Cell membrane Cytoskeleton (actin, microtubules) Posttranslational protein modification Van Wyk (2004)

The Power of Natural substances molecular dna telomere science cell ch 3 stem cell from TRADITIONAL to ADVANCE MEDICINE mitochondria

Finding Pieces of the Puzzle “Functional” Physician Perspectives Biologic alteration Impaired Cellular Functional Changes Pathology No Symptom Subclinical Early stage END STAGE Enzyme assays Intracellular stimulation as functional indication Biomarkers Most obvious way to assess patient status, clinically Saturation measures More functional need assessment tool as better picture Challenge tests Assess a specific valuable pathway to direct assess of function

The Evolution of Lab markers Serum Marker 1 st GENERATION ID gene Specific Mutations 2 nd GENERATION Genes Expression 3 rd GENERATION Functional Profiles 4 th GENERATION

Naturoceutical scope intervention on cancer Nutraceutic al WCRF International

Aggarwal BB, et al Adv Exp Med Biol. 2007; 595: 1 -75

The Role of Nutraceutical for Biomolecular Cellular Activities

Micro Chinese Medicine Osmotherapy new and modernize medical institute integrating medicine, teaching and research a concoction of traditional Chinese herbs to treat the most severe forms of kidney disease. the medication can also be put in a bag and applied to the kidneys externally by machine. - stop blood and protein in urine, - raise GFR and reverse kidney damage - worked on over 90% of ckd cases 12 Jan – 09 Feb 2019 Beijing Tongshantang Hospital of Traditional Chinese Medicine

ISOGENIC APPROACHES on CANCER Natural Substances J Nutr. 2005 Jul; 135(7): 1613 -6 - Science Direct. Volume 21, Issue 6, June 2010, Pages 457– 467

C dif ellula y re r e pla spon vents nt com se to can po Bioa nen ct ts ive mo Functional modules ts ennts nve proe nts ula eve colm nt el lar plafy c llu ive diy ce act odif Bio nmmo cacna Metabolites Proteins m. RNA Genes Phenotype Metabolic pathways

Epigenomic CH 3 -DNA Nutrigenetic Nutrigenomic Post translational DNA m. RNA Proteins Bioactive Food Components Enzyme, Structural Transport, Signaling caused by Phosphorylation and Glycocylation

Interaction nutrients with genetic and epigenetic as to lead to a phenotype change NUTRIENT SPECIFIC BIOAVAILABILITY NEGATIVE EFFICACY BIOLOGICAL MODIFICATION SUPPORT DETOXYGENIC ENZYME BLOCK CARCINOGENIC BUILD UP HORMONAL HOMEOSTASIS CHANGE DELAY CELL DIVISION REDUCE APOPTOSIS GENETIC MANIPULATION Int’l Life Science Symposium, Paris 2001

Plant secondary metabolite Phytoactive Phytonutrient Phytochemical Phytoenzyme Phytohormone Phyto-allel Human cells & genes • • • Gene Gene transcription modulation regulation translation expression Recuperation Rejuvenation Revitalization Miller G, 1997 – J of Am Col Nutr; 16: 293 -295

DNA repair Carcinogen metabolism Hormonal regulation Bioactive component Cell cycle Differentiate Apoptosis

genome dna Biochemical and Biophysical Research Communications Volume 378, Issue 1, 2 January 2009, Pages 6– 9

The basis study of Nutraceutical for cellular lifespan process Nutraceutic al WCRF International

Telomerase & Cancer

ö Supply of methyl groups inhibit DNA methylation processes ö Modify the use of methyl groups DNA methyltransferase reaction ö Response to bioactive components influence DNA demethylation ö Ability to interact at molecular level DNA methylation patterns Methylation Switching genes on or off which alters genetic messages and modify genetic expression

9 -11 September 2016, Cochine - India Herbs = Plant = Nature

Natural substances – Mitochondria = Malignancy

Growing burden Non communicable Infectious disease Rising economic growth ↓ Fiscal capacity NEW HEALTH POLICY BPJS Robust health care & Catastrophic costs

Lets preserve what nature gives us, take good care of them and it will do the same Good Nature ≡ Old Days