Kinetics and Mechanism of the Hydrolytic Degradation of Slides: 11 Download presentation Kinetics and Mechanism of the Hydrolytic Degradation of Indinavir: Intramolecular Catalysis Maria M. Toteva, Roger Zanon, Drazen Ostovic JPharm. Sci Volume 97 Issue 9 Pages 3810 -3819 (September 2008) DOI: 10. 1002/jps. 21259 Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Scheme 1 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Figure 1 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Figure 2 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Figure 3 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Scheme 2 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Figure 4 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Scheme 3 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Scheme 4 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Scheme 5 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Scheme 6 JPharm. Sci 2008 973810 -3819 DOI: (10. 1002/jps. 21259) Copyright © 2008 Wiley-Liss, Inc. Terms and Conditions Estimating the degradation functionEdman degradation stepsPurinesMechanical degradationDegradation of ketone bodiesHow environmental degradation occursNoiseLight induced degradationEdman degradationPurification yield calculationConclusion of environmental degradationHow environmental degradation occurs