Key learnings and Take away Jacques Koolen Catharina

Key learnings and Take away Jacques Koolen Catharina hospital Eindhoven The Netherlands

Jacques Koolen MD Ph. D Disclosure I m consultant for Biotronik I m consultant for Medtronic

Technology Review technology Clinical Performance Prof. M Haude 2. Design & Surface 1. 3. 4. 6. 5. 1. 2. 3. 4. 5. 6. Casting Extrusion Drilling Drawing Laser Beam Cutting Electro Polishing 10 m 4 m; mg

100 % succes No MACCE in >10 years (progression disease excluded ) No foreign body incorpus The Holy Grail

Or never finished ?

Bioflow studies in Depth ORSIRO

Prof C von Birgelen Challenging cases/all commers

Group Discussion

THANK YOU

Group discussion

Procedural Success by JCTO Score according to Experience in Retrograde p<0. 01 % Low = <50 procedure retrograde Moderate = 50 -100 retrograde Good = >100 retrograde

Procedural Success by JCTO Score according to Experience in Retrograde p<0. 01 % Low = <50 procedure retrograde Moderate = 50 -100 retrograde Good = >100 retrograde

Challenging Cases Prof C von Birgelen

Evolution of BIOTRONIK Magnesium Scaffold for achieving the optimal design requirements AMS DREAMS 1 G DREAMS 2 G 2004 2010 2013 Mg Refined alloy Alloy Clinical study: Refined alloy PLGA Polymer No coating No drug Mg Mg Improvements: § Mg alloy § Backbone § Coating § Drug Paclitaxel Clinical study: PLLA Polymer Improvements: § Mg processing § Backbone § Coating § Drug Sirolimus Clinical study:

99, 999999 % procedural succes < 1 % MACCE ? In > 10 years time Unrelated to underlying disease W Wijns