July 2012 doc IEEE 802 15 12 0394

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Project: IEEE P 802. 15 Working Group for Wireless Personal Area Networks (WPANs) Submission Title: Overview of I 2 R’s Wireless Transceiver Design for MBAN Activities Date Submitted: July 17, 2012 Source: Dr. Sumei Sun Contact: Dr. Sumei Sun, Institute for Infocomm Research (I 2 R), (sunsm@i 2 r. astar. edu. sg), Dr. Xiaoming Peng (pengxm@i 2 r. a-star. edu. sg) Re: Overview of I 2 R’s Wireless Transceiver Design for MBAN Activities Abstract: Purpose: To focus activities during the meeting Notice: This document has been prepared to assist the IEEE P 802. 15. It is offered as a basis for discussion and is not binding on the contributing individual(s) or organization(s). The material in this document is subject to change in form and content after further study. The contributor(s) reserve(s) the right to add, amend or withdraw material contained herein. Release: The contributor acknowledges and accepts that this contribution becomes the property of IEEE and may be made publicly available by P 802. 15. Submission Slide 1 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Outline • Background • Wireless Transceiver design for In-body Diagnosis • Wireless Transceiver for Implantable Device for Treatment Submission Slide 2 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n • Background • Wireless Transceiver design for In-body Diagnosis • Wireless Transceiver for Implantable Device for Treatment Submission Slide 3 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n The A*STAR Family Institute of High Performance Computing (IHPC) Data Storage Institute (DSI) Submission Institute for Chemical & Engineering Sciences (ICES) Institute of Microelectronics (IME) Slide 4 Singapore Institute of Manufacturing Technology Institute of (SIMTech) Materials Research & Engineering (IMRE) Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n A*STAR’s BEP Program • The Biomedical Engineering Programm (BEP) is a competitive, multi-disciplinary grant programm • Aiming at engaging the local clinical community with engineers and scientists to develop cost-effective innovations through a needsdriven approach that will improve patient care • Funded by the Science and Engineering Research Council (SERC) of A*STAR • Supports Clinician-Engineer/Scientist collaborative research projects with emphasis on devices, procedures, diagnosis, and clinical systems • The two use cases we share in this presentation are supported under the Program. Submission Slide 5 Sumei Sun, I 2 R

doc. : IEEE 802. 15 -12 -0394 -00 -004 n Outline • Background • Wireless Transceiver design for In-body Diagnosis • Wireless Transceiver for Implantable Device for Treatment Submission

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Introduction • Capsule endoscopy is a technique which facilitates imaging of the gastro -intestinal track • Can be used to evaluate cause of gastro-intestinal bleeding and the surveillance of small bowel tumor and polyps • Safe and well-tolerated procedure, with low complication rates Submission Slide 7 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Project objective • Develop wireless comms module for swallowable capsule • In-body diagnostics Camera Submission 26 mm Comms & Application Module Battery/S tandard Module Slide 8 Antenna 11 mm Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Existing Comms Transceiver • Zarlink MICS Transceiver – ZL 70101 • • RF Band – 402 to 405 MHz • Max data rate – 800 kbps • FSK modulation • Low power Submission Slide 9 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Comms Requirements (1/2) • Primary function – Transmit up to 6 x VGA quality images per second • Translates to 1. 5 to 3 Mbps – existing transceiver cannot achieve this data rate • Other functionalities include: – temperature sensing – p. H sensing – capsule status indication Submission Slide 10 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Comms Requirements (2/2) • Provide limited control of capsule (low data rate) – – Toggle between sleep / active mode Actuators control Activation of biomarkers Adjust image compression ratio • RF Band – 921 to 924 MHz – antenna more compact in 900 MHz than in 400 MHz band • Low power Submission Slide 11 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n PHY Layer Design (1/2) • Comms receivers are typically more complex than transmitters • Shift system complexities to external base station to reduce power • Asymmetric comms link between in-body capsule and external base station • Modulation: – Capsule – QPSK Tx / OOK Rx – Base station – OOK Tx / QPSK Rx Submission Slide 12 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n PHY Design (2/2) • Error correction: – Capsule • Reed-Solomon (255, 239) encoder • 1/3 repetition code decoder – Base station • 1/3 repetition code encoder • Reed-Solomon (255, 239) decoder • Data rates: – Capsule to base station – 3 Mbps – Base station to capsule – 50 kbps Submission Slide 13 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Antenna Design • Capsule – Coil antenna – Radiation – Omni-directional – Dimension – 5 x 5 mm 3 • Station – Patch antenna – Radiation - Directional – Dimension – 100 x 4. 6 mm 3 Submission Slide 14 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n The Animal Trial The standalone capsule Submission The capsule in pig’s stomach Slide 15 Sumei Sun, I 2 R

doc. : IEEE 802. 15 -12 -0394 -00 -004 n Outline • Background • Wireless Transceiver design for In-body Diagnosis • Wireless Transceiver for Implantable Device for Diabetes Treatment Submission

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Background and Motivation • 286 million diabetics worldwide, 400 million by 2030 • ~10% of the Singapore population has diabetes • 7 th leading cause of death in Singapore , • ~US$116 billion was spent on the direct medical cost for diabetes in 2007 (in US alone) • All Type I and ~30% of Type 2 diabetics require insulin therapy • Painful fingerpricks (blood glucose testing) and insulin injections • Psychological aversion to therapy non-compliance (as high as 50%) – Non- compliance increases the risk of developing systemic sequelae Submission Slide 17 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Some Available Advanced Solutions • Implanting of semi-permanent glucose-sensing and insulin-delivery components - Medtronic, Johnson & Johnson, Roche, Abbott, and Animas • New forms of insulin - Exubera by Pfizer, an inhaled form of insulin (withdrawn due to fears of pulmonary side effects) Submission Slide 18 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Our Objective • Develop a proof-of-concept prototype for implantable close-loop glucose control – A closed-loop glucose regulation algorithm – A bench model for testing and developing the above algorithm – A fail-safe system to prevent hypoglycaemia based on graded alarms and glucose-insulin co-infusion – A wireless transceiver – A power management module with embedded wireless inductive power charging capabilities Submission Slide 19 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Lab Bench Prototype Platform for Base Station (external unit) Submission Platform for Implantable Device (internal unit) Slide 20 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Lab Bench Prototype Base Station Communicating with Implantable unit Submission Slide 21 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Validation of Control Algorithm Case 1 - Type 1 Patient Cases 2 and 3 – A Type 2 Patient monitored in March and April 2011 Modeled glucose level and clinical data were shown in the top panel; and in the bottom panel the red dash curve and the green solid line represented glucose intake rate Gin (mg/d. L) and insulin injection u (m. U/min), respectively. Submission Slide 22 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Test and Trial with Pork Meat Submission Slide 23 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Prototype for Upcoming Animal Test Submission Slide 24 Sumei Sun, I 2 R

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Power Management • Energy consumption profiling – Conducted experiment on energy consumption profile of the implant device in various operation modes – Will be used to further optimize power management mechanism • Energy harvesting/charging mechanism – Conducted experiments on resonant-based wireless power transfer/charging – Design is on-going Submission Slide 25 Sumei Sun, I 2 R

doc. : IEEE 802. 15 -12 -0394 -00 -004 n Summary and discussions • Two wireless transceiver design projects have been presented – One with short-life cycle, high data rate – One with long life-cycle, moderate or low data rate • Higher and higher demand for intelligent healthcare/lifesyle management – Calling for unified/inter-operable communication standard Submission

July 2012 doc. : IEEE 802. 15 -12 -0394 -00 -004 n Thank You! Q&A Submission Slide 27 Sumei Sun, I 2 R