JPIAMR Joint Research Calls Update on Calls Management

JPIAMR Joint Research Calls – Update on Calls Management Board Meeting 24 th October, 2018 Virginie Mouchel France Laura Plant JPIAMR Secretariat

Overview of Calls • JPIAMR 6 th Call: New targets, compounds and tools • JPIAMR 7 th Call: Working to improve Surveillance @jpionamr www. jpiamr. eu

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New targets, compounds and tools: Full Proposals @jpionamr www. jpiamr. eu

New targets, compounds and tools: Funded Projects Acronym Title ANTIBIO-LAB Anti-Biofilm therapies using Local Application of bacteriophages Anti. Persistence CRISPRattac. K DISRUPT Explore FLAV 4 AMR MTI 4 MDR-TB RESET-ME RIBOTARGET SCAN Coordinator and partners Countries Fintan Moriarty, Andrej Trampuz, Metsemakers Willem-Jan, David Eglin, Rob Lavigne, Mariagrazia Di Luca Fighting antibiotic-resistant superbugs with anti. Abel Garcia-Pino, Leonardo Pardo, Ewa persister compounds targeting the stringent response Laskowska, Olivier Neyrolles Advancing CRISPR antimicrobials to combat the Chase Beisel, Udi Qimron, David Bikard, Dr. bacterial pathogen Klebsiella pneumoniae Sylvain Brisse, Strowig Till Fighting antimicrobial resistant infections by high. Morten Kjos, Jan-Willem Veening, Athanasios throughput discovery of biofilm-disrupting agents Typas, Christoph Merten and mechanisms Exploration of the TPP riboswitch as a new target for Ruth Brenk, Petr Bartunek, Matthias Mack, antibiotics Gints Smits, Daniel Lafontaine Belgium, Switzerland, Germany Belgium, France, Spain, Poland Israël, France, Germany Norway, Germany, Switzerland Canada, Czech Republic, Latvia, Germany, Norway Flavodoxin inhibitors to kill resistant bacteria Javier Sancho, Eliette Touati, Ultrich E Schaible, France, Germany, Spain Alain Bousquet-Melou Development of novel Mycobacterial Tolerance Fredrik Almqvist, Camille Locht, Tone Tønjum, France, Norway, Spain, Inhibitors (MTIs) against MDR/XDR tuberculosis Jesús Blázquez, Christina Stallings Sweden, United states Restoring E. coli Sensitivity for Antibiotics by blocking Björn Windshügel, Mathias Winterhalter, Päivi Finland, Germany, Italy, Tol. C-Mediated Efflux Tammela, Aigars Jirgensons, Matteo Ceccarelli Latvia, DEVELOPMENT OF NOVEL RIBOSOME-TARGETING Daniel Wilson, C. Axel Innis, Erik Böttger, Vasili Czech Republic, France, ANTIBIOTICS Hauryliuk, Reynald Gillet, Dominik Rejman Germany, Sweden, Switzerland Design, Synthesis and Lead Generation of Novel Mark Brönstrup, Doron Shabat, Isabelle Schalk France, Germany, Israël Siderophore Conjugates for the Detection and Treatment of Infections by Gram-Negative Pathogens @jpionamr www. jpiamr. eu

New targets, compounds and tools: Summary 10 projects will be funded with a total budget of 11, 771, 433 € 12 th of October 2018: Final funding decisions announced to applicants End of 2018/Early 2019 : Start of funding @jpionamr www. jpiamr. eu

Call for networks Working to improve surveillance The call aims to create networks to enhance resource alignment and efforts in the field of AMR surveillance. Up to 21 networks will be funded with up to € 50 000 each, starting 2018/early 2019. Note that the call does not fund research projects. Publication of call May 2 nd 2018 No. of participating countries 10 Deadline proposals June 12 th 2018 Budget € 50 000/network @jpionamr www. jpiamr. eu

Working to improve surveillance Participating countries: Belgium (FWO), France (ANR), Germany (BMBF), Ireland (HRB), Italy (MOH), Norway (RCN), Sweden (SRC), Spain (ISCIII), The Netherlands (Zon. Mw), UK (MRC-UKRI). Joint Call Secretariat: Swedish Research Council @jpionamr www. jpiamr. eu

Working to improve surveillance Received: 16 applications eligible, 1 ineligible Total 364 partners from 63 different countries Country of Coordinator France Germany Ireland Sweden No of Applications 6 3 1 1 The Netherlands UK 3 2 @jpionamr www. jpiamr. eu

0 Argentina Australia Austria Bangladesh Belgium Benin Brazil Burkina Faso Cameroon Canada China Croatia Czech Republic Democratic Republic of the Congo Denmark Estonia Finland France Gabon Georgia Germany Ghana Greece Guinea Bissau Hungary India Indonesia Ireland Israel Italy Ivory Coast Kenya Latvia Lebanon Lithuania Madagascar Malaysia Mali Mexico Moldova Mongolia Niger Norway Pakistan Poland Portugal Russia Saudi Arabia Senegal Slovenia South Africa Spain Sweden Switzerland Thailand The Gambia The Netherlands Togo Tunisia UK USA Vietnam Working to improve surveillance: Geographical Distribution of Applicants 60 50 40 30 20 10 @jpionamr www. jpiamr. eu

Working to improve surveillance: Summary Networks start Dec 2018/Jan 2019 Recommended for funding: 10 networks* + 2 workshops *Awaiting final funding decisions of agencies @jpionamr www. jpiamr. eu

8. Other 7. Social networks, big data and deep learning x x x x Providing a roadmap for automated surveillance in Europe SOLIDNESS – Surveillance of mobiliome mediated antibiotic resistance spread x x x Intensive care airway and lung microbiome network - ICALM Kleb. Net: A One Health Network bridging science and surveillance of antibiotic resistance x Convergence in evaluation frameworks for integrated surveillance of AMR 6. Surveillance technologies and tools 5. Quality assurance, curation and sharing data 4. Improvement and standardisation of methods 3. Surveillance of nonhuman AMR reservoirs 2. Surveillance of AMR in the healthy population 1. Impact of surveillance Wildlife, Agricultural soils, Water environments and antibiotic resistance – what is known, needed and feasible for global Environmental Surveillance (WAWES) Network for Enhancing Tricycle ESBL Surveillance Efficiency (NETESE) National healthcare infrastructures , health care utilisation and patient movements between hospitals Towards developing an international environmental AMR surveillance strategy Bridging the gap between human and animal surveillance data, antibiotic policy and … x x x x @jpionamr Evaluation of integrated www. jpiamr. eu surveillance on AMR www. jpiamr. eu

Working to improve surveillance: Links with the JPIAMR-VRI Networks calls have same timeline Start-up and final workshops will (hopefully) be organised back-to-back • Overlapping sessions • Engagement of Surveillance Coordinators in the JPIAMR-VRI workshops @jpionamr www. jpiamr. eu