Journal Club Duckworth W Abraira C Moritz T

Journal Club Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, Mc. Carren M, Vitek ME, Henderson WG, Huang GD; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009 Jan 8; 360(2): 129 -39. Epub 2008 Dec 17. Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, 　Bolotin A, Vardi H, Tangi-Rozental O, Zuk-Ramot R, Sarusi B, Brickner D, Schwartz Z, 　Sheiner E, Marko R, Katorza E, Thiery J, Fiedler GM, Blüher M, Stumvoll M, Stampfer MJ; 　Dietary Intervention Randomized Controlled Trial (DIRECT) Group. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med. 2008 Jul 17; 359(3): 229 -41. 2009年 2月5日　8: 20 -8: 50 B棟８階　カンファレンス室 亀田メディカルセンター　糖尿病内分泌内科 Diabetes and Endocrine Department, Kameda Medical Center 松田　昌文 Matsuda, Masafumi

Original Article Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes William Duckworth, M. D. , Carlos Abraira, M. D. , Thomas Moritz, M. S. , Domenic Reda, Ph. D. , Nicholas Emanuele, M. D. , Peter D. Reaven, M. D. , Franklin J. Zieve, M. D. , Ph. D. , Jennifer Marks, M. D. , Stephen N. Davis, M. D. , Rodney Hayward, M. D. , Stuart R. Warren, J. D. , Pharm. D. , Steven Goldman, M. D. , Madeline Mc. Carren, Ph. D. , M. P. H. , Mary Ellen Vitek, William G. Henderson, Ph. D. , Grant D. Huang, M. P. H. , Ph. D. , for the VADT Investigators N Engl J Med Volume 360(2): 129 -139 January 8, 2009

Study Overview • In this study, 1791 military veterans with poorly controlled type 2 diabetes were randomly assigned to receive either standard or intensive glucose control • Other cardiovascular risk factors were treated uniformly • The glycated hemoglobin goal was an absolute reduction of 1. 5 percentage points in the intensivetherapy group • There was no significant difference between the two groups for the rates of major cardiovascular events, death, or microvascular complications

Enrollment and Outcomes Duckworth W et al. N Engl J Med 2009; 360: 129 -139

Characteristics of the Patients at Baseline and Follow-up Duckworth W et al. N Engl J Med 2009; 360: 129 -139

Changes in Median Glycated Hemoglobin Levels from Baseline through 78 Months Duckworth W et al. N Engl J Med 2009; 360: 129 -139

Kaplan-Meier Curves for the Time until the First Occurrence of a Primary or Secondary Outcome Duckworth W et al. N Engl J Med 2009; 360: 129 -139

Hypoglycemic Episodes Duckworth W et al. N Engl J Med 2009; 360: 129 -139

Microvascular Outcomes Duckworth W et al. N Engl J Med 2009; 360: 129 -139

Conclusion • Intensive glucose control in patients with poorly controlled type 2 diabetes had no significant effect on the rates of major cardiovascular events, death, or microvascular complications

Myocardial Infarction Mannucci E et al: NMCD 2009 in press

Stroke Mannucci E et al: NMCD 2009 in press

Original Article Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet Iris Shai, R. D. , Ph. D. , Dan Schwarzfuchs, M. D. , Yaakov Henkin, M. D. , Danit R. Shahar, R. D. , Ph. D. , Shula Witkow, R. D. , M. P. H. , Ilana Greenberg, R. D. , M. P. H. , Rachel Golan, R. D. , M. P. H. , Drora Fraser, Ph. D. , Arkady Bolotin, Ph. D. , Hilel Vardi, M. Sc. , Osnat Tangi-Rozental, B. A. , Rachel Zuk-Ramot, R. N. , Benjamin Sarusi, M. Sc. , Dov Brickner, M. D. , Ziva Schwartz, M. D. , Einat Sheiner, M. D. , Rachel Marko, M. Sc. , Esther Katorza, M. Sc. , Joachim Thiery, M. D. , Georg Martin Fiedler, M. D. , Matthias Blüher, M. D. , Michael Stumvoll, M. D. , Meir J. Stampfer, M. D. , Dr. P. H. , for the Dietary Intervention Randomized Controlled Trial (DIRECT) Group N Engl J Med Volume 359(3): 229 -241 July 17, 2008

Study Overview • This 2 -year trial, which took place in an isolated workplace that facilitated retention in the study, randomly assigned 322 moderately obese subjects to one of three diets: a low-fat, restricted-calorie diet; a Mediterranean, restricted-calorie diet; or a low-carbohydrate, non-restricted-calorie diet • The results suggest that the Mediterranean and low-carbohydrate diets are effective alternatives to low-fat diets and that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions

Baseline Characteristics of the Study Population Shai I et al. N Engl J Med 2008; 359: 229 -241

Enrollment of the Participants and Completion of the Study Shai I et al. N Engl J Med 2008; 359: 229 -241

Changes in Dietary Intake, Energy Expenditure, and Urinary Ketones during 2 Years of Intervention Shai I et al. N Engl J Med 2008; 359: 229 -241

Changes in Dietary Intake, Energy Expenditure, and Urinary Ketones during 2 Years of Intervention Shai I et al. N Engl J Med 2008; 359: 229 -241

Weight Changes during 2 Years According to Diet Group Shai I et al. N Engl J Med 2008; 359: 229 -241

Changes in Cholesterol and Triglyceride Biomarkers According to Diet Group during the Maximum Weight-Loss Phase (1 to 6 Months) and the Weight-Loss Maintenance Phase (7 to 24 Months) of the 2 -Year Intervention Shai I et al. N Engl J Med 2008; 359: 229 -241

Changes in Biomarkers According to Diet Group and Presence or Absence of Type 2 Diabetes Shai I et al. N Engl J Med 2008; 359: 229 -241

Conclusion • Mediterranean and low-carbohydrate diets may be effective alternatives to low -fat diets • The more favorable effects on lipids (with the low-carbohydrate diet) and on glycemic control (with the Mediterranean diet) suggest that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions