Joint effects of cancer and variants in the

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Joint effects of cancer and variants in the factor 5 gene on the risk

Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism by Olga V. Gran, Erin N. Smith, Sigrid K. Brækkan, Hilde Jensvoll, Terry Solomon, Kristian Hindberg, Tom Wilsgaard, Frits R. Rosendaal, Kelly A. Frazer, and John. Bjarne Hansen haematol Volume 101(9): 1046 -1053 August 31, 2016 © 2016 by Ferrata Storti Foundation

Flowchart illustrating the composition of the case–cohort study. Olga V. Gran et al. Haematologica

Flowchart illustrating the composition of the case–cohort study. Olga V. Gran et al. Haematologica 2016; 101: 1046 -1053 © 2016 by Ferrata Storti Foundation

Hazard ratios for VTE at 6 -month intervals starting from 1 year before cancer

Hazard ratios for VTE at 6 -month intervals starting from 1 year before cancer diagnosis. Olga V. Gran et al. Haematologica 2016; 101: 1046 -1053 © 2016 by Ferrata Storti Foundation

Baseline characteristics of the study population according to cancer status. Olga V. Gran et

Baseline characteristics of the study population according to cancer status. Olga V. Gran et al. Haematologica 2016; 101: 1046 -1053 © 2016 by Ferrata Storti Foundation

Age- and sex-adjusted hazard ratios for VTE according to categories of F 5 rs

Age- and sex-adjusted hazard ratios for VTE according to categories of F 5 rs 6025 (FVL) and F 5 rs 4524 risk alleles and cancer. Olga V. Gran et al. Haematologica 2016; 101: 1046 -1053 © 2016 by Ferrata Storti Foundation

Age- and sex-adjusted hazard ratios for VTE by categories of FVL and F 5

Age- and sex-adjusted hazard ratios for VTE by categories of FVL and F 5 rs 4524 risk alleles among those with active cancer. Olga V. Gran et al. Haematologica 2016; 101: 1046 -1053 © 2016 by Ferrata Storti Foundation

Additive interaction between F 5 variants and active cancer. Olga V. Gran et al.

Additive interaction between F 5 variants and active cancer. Olga V. Gran et al. Haematologica 2016; 101: 1046 -1053 © 2016 by Ferrata Storti Foundation

Cumulative incidence of VTE in the presence of F 5 rs 6025 (FVL) and

Cumulative incidence of VTE in the presence of F 5 rs 6025 (FVL) and F 5 rs 4524 risk alleles during the active cancer period. Olga V. Gran et al. Haematologica 2016; 101: 1046 -1053 © 2016 by Ferrata Storti Foundation