Joe Donahue Managing Director Global Life Sciences RD

TOPICS ME ACCENTURE SOME INDUSTRY CHALLENGES A POSSIBLE DIRECTION YOUR QUESTIONS (if any) Copyright

FIVE THINGS TO REMEMBER CLOUD PRE-COMPETITIVE EXTERNALIZATION COMPONENTIZATION “THE NEW” Copyright © 2018 Accenture.

RELATIONSHIPS WITH 5, 000+ CLIENTS IN 120+ COUNTRIES All 100 of our top 100 clients have been clients for at least 5 years 5 94 OF THE GLOBAL 98 of our top 100 clients have been clients for at least 10 years ARE ACCENTURE CLIENTS 10 75 %+ OF THE GLOBAL >435, 000 employees (>16, 000 in Life Sciences), FY 17 revenues of $34. 9 B Copyright © 2018 Accenture. All rights reserved. Proprietary and Confidential. 4

ACCENTURE IN RESEARCH INFORMATICS Custom cloud implementations / projects and platforms Genomics – NGS pipeline analysis, variant interpretation, biomarker discovery Software customization / configuration / implementation and support – Chemical and biological entity registration, Inventory management, Analytics and reporting, data models, workflow and script development, ELN’s, LIMS, etc. Informatics / IT roadmaps and strategy Software / system evaluation and recommendations Joint projects with Research Ecosystem ISV Partners - data integration, data cleansing, AI/ML, IOT, software implementation, genomics testing / target ID and validation, NLP, Translational genomics, chemical formulation repositories etc.

SUMMARY The Pharma industry is struggling with a common set of informatics challenges that are impacting their ability to drive Research faster, more efficiently and leading to better outcomes. We can change this paradigm by leveraging proven business models and technologies to drive improvements in productivity, efficiency, innovation and user experience. Precompetitive approaches are being embraced in our industry, and can provide an opportunity to drive differentiated outcomes, enabling better capabilities, faster and at a lower cost (shared cost model) Copyright © 2018 Accenture. All rights reserved. 6

RESEARCH TRANSFORMING Over the past two years, Accenture engaged with 40+ organizations to further our understanding of their Research Informatics challenges and support needs The Changing Ecosystem Science and technology breakthroughs Data Externalization volume & types Io. T, Mobility, Cloud Machine Learning Time and effort to IND Infrastructure Costs Nontraditional players Disparity across industry Precision / Outcomes Simulation & modeling Barriers to new capabilities Collaboration ramp up time Paper One directional processes Copyright © 2018 Accenture. All rights reserved. More Manual analysis Less Manual data collation Repeat experimentation Dark data & data silos Long Software implementations Stop

RESEARCH TRANSFORMING Over the past two years, Accenture engaged with 40+ organizations to further our understanding of their Research Informatics challenges and support needs The Changing Ecosystem Non-traditional players Data volume & types Analytics Simulation & modeling Science and technology breakthrough Io. T, Mobility, Cloud Infrastructure costs • Global data accessibility and end-to-end data management More Barriers to new capabilities Manual analysis Time and effort to IND Disparity across industry One directional process Collaboration ramp up time Less Copyright © 2018 Accenture. All rights reserved. • Secure environment to enable collaboration agility • Advanced decision support, ML/AI • Modern UI/User Experience • Platform for rapid application deployment and development Long SW implementations Dark data & data silos Data Infrastructure Repeat experimentation Paper Applications Services Machine Learning Precision / Outcomes Integration Externalization Next Generation Research Support Manual data collation Stop • Multi-tenant, open cloud platform, and shared cost structure 8

A BETTER WAY TO SUPPORT EXISTING APPS Why can’t we leverage cloud computing and wrap applications around standards for data ingestion, aggregation, search and collaboration? Enable Internal & External Collaboration Access & Exchange, Security Services ELN Assay data mgmt. Request / workflow Analytics & visualization Biologics Entity registration Report creation Compound / sample mgmt. ML / Predictive Analytics Chemistry data warehouse Systems biology Assay protocol mgmt. Data Enrichment and Relationship Linking Data Standardization Data Capture and Ingestion Cloud Infrastructure Copyright © 2018 Accenture. All rights reserved. 9

MUST BE BETTER AT EMBRACING THE NEW Adoption of new technologies to accelerate research • Fragmentation of large traditional apps into discrete capabilities to provide greater flexibility and accelerates IT innovation • Real-time patient info for translational research • Remote access / control of lab instruments (e. g. , LIMS) “Appified” Research Tools • Seamless collaboration with ext. research centers • Request mgmt. and data sharing with CROs • Rapid deployment of firewalled partnerships environments Io. T / Wearables, Connected Lab • High throughput / parallelized molecular biology (e. g. , antibody discovery, CRISPR) • Hypervariable analysis (e. g. , high content screening, genotype-phenotype correlation) Sophisticated, Secure Collaboration Tools • Modern, consistent look and feel across IT app landscape • Mobile enabled scientific apps for use within the lab AI / Machine Learning, Robotics Copyright © 2018 Accenture. All rights reserved. Scientific User Experience of the Future

A PRE-COMPETITIVE PLATFORM ECOSYSTEM APPROACH TO RESEARCH INFORMATICS? Open, multi-tenant, shared services, and secure data (that can be provisioned to collaborators) Research Informatics Software, Content and Services Companies Platform Ecosystem Multi-tenant Cloud infrastructure Analytics Medical Institution OMICS Data Pharma Co. 1 Applications Data Services AI / Analytics Integration LIMS ELN Pharma, Biotech, CROs and Medical Institutions Biotech Co. 1 CRO Co. 1 Biotech Co. 2 Infrastructure SDMS Medical Institution Request Management Entity Registration CRO Co. 2 Assay Mgt. Pharma Co. 2 Biotech Co. 3 Bio Pathways Visual Analytics Copyright © 2018 Accenture. All rights reserved. Pharma Co. 3 11