JhengFong Jhong Yung Chang 20121120 RD Center for

雙離子性氟素材於傷口癒合之應用開發 Jheng-Fong Jhong(鍾政峰), Yung Chang (張雍), 2012/11/20 R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan University, Taiwan (中原大學薄膜技術研發中心) 1

雙離子性氟素材於傷口癒合之應用開發 General concept of wound healing 2 Jheng-Fong Jhong R&D Center for Membrane Technology

雙離子性氟素材於傷口癒合之應用開發 Membranes used in human body n The performance of designed surfaces contact with human blood? General Surface Designed Surface Hemocompatible Control 3 Jheng-Fong Jhong R&D Center for Membrane Technology

雙離子性氟素材於傷口癒合之應用開發 General synthetic systems polyether Widely used: “Ideal anti-fouling candidates Oligo(ethylene glycol) (OEG)-based materials Cell membrane Bio-mimetic “Nature bioinert surface” Sulfobetaine methacrylate (SBMA) Poly(ethylene glycol) (PEG)-based materials 4 Jheng-Fong Jhong R&D Center for Membrane Technology

Plasma treatment Atmospheric Pressure Plasma Jet (APPJ) Flow rate: 10 slm Ar March box Argon Plasma jet Sample 150 W < > RF power generator Input power: 150 W Characterization p Without vacuum system p Time reduction X-Y axis controller 5 Jheng-Fong Jhong p Low energy consumption R&D Center for Membrane Technology

雙離子性氟素材於傷口癒合之應用開發 Plasma induced surface modification Ar+ F 6 F Jheng-Fong Jhong F R&D Center for Membrane Technology

雙離子性氟素材於傷口癒合之應用開發 Plasma induced surface modification + + Biomimetic Interface 7 Jheng-Fong Jhong R&D Center for Membrane Technology

雙離子性氟素材於傷口癒合之應用開發 Animal wound healing test 2. 5 cm 1 cm 1. 5 cm 1 cm SD rat 1. 5 cm Age 8~10 week (420 g) 8 Jheng-Fong Jhong wound R&D Center for Membrane Technology

雙離子性氟素材於傷口癒合之應用開發 Platelet RBC Bacterial 9 Jheng-Fong Jhong R&D Center for Membrane Technology

雙離子性氟素材於傷口癒合之應用開發 10 Jheng-Fong Jhong R&D Center for Membrane Technology

Acknowledgement We wish to express their sincere gratitude to The Center-of-Excellence (COE) Program on Membrane Technology from the Ministry of Education (MOE), R. O. C. The National Science Council for their financial support. CENTER for MEMBRANE T ECHNOLOGY RESEARCH & DEVELOPMENT 11 Jheng-Fong Jhong R&D Center for Membrane Technology

THANK YOU FOR YOUR ATTENTION 12 Jheng-Fong Jhong R&D Center for Membrane Technology