Jeopardy Rules of the game Each team or

Jeopardy

Rules of the game: • Each team or group can work together as a team. As the questions cover Apheresis categories, the : “First Team or Group” team with the most points at the end of the game will be declared as the winner. • Just like the real Jeopardy game, when a category and point value are chosen, we will give you the answer and you must give us the question, in the form of a question. • This is Apheresis Fun and Trivia you will not be penalized for incorrect answers. “Have A Great Time”

Not Heparin But That’s My Name What could it be Picture This Cells and Such 100 100 100 200 200 200 300 300 300 400 400 400 500 500 500

What is The AC Infusion Rate This image describes the consequences of changing what? tt

Waldenstrom’s Macroglobulinemia Initial symptoms this disease are fatigue and weight Loss but soon include: hyperviscous serum, congestive heart failure, decreased blood flow to cerebrial, cardiac and pulmonary circulation, headache, vertigo, vision loss, etc. The slow synthesization of the large Ig. M molecules, however, make them remain largely intravascular making apheresis particularly effective.

What are dendritic cells? Collection of this mononuclear cell type is used for production of vaccines to combat pancreatic cancer and melanoma among others.

What is Uvadex? Photosensitivity is a concern with the use of ____ and precautions should be taken to minimize exposure of skin and eyes.

What is Traceability? A cornerstone of good manufacturing practice (GMP) for incoming and outgoing materials. It is especially important for materials and components that become part of the product or that directly contact the product during the manufacturing proceed.

What is Citrate? _____in ACD-A is the primary molecule responsible for anticoagulation in the extracorporeal circuit.

GOODPASTURE’S SYNDROME A rare and organ-specific autoimmune disease. It is mediated by anti-glomerular basement membrane (anti-GBM) antibodies directed against a domain of a 3 chain of Type IV collagen, causing activation of the complement cascade, resulting in tissue injury due to a classic Type II reaction.

What is AMD 3100? This relatively new drug, which the FDA allows for research use only, is used along with GCSF to prime poor mobilizers.

What is 27%? What should the patients minimal HCT be to perform a Photo Procedure on the Cellex?

What is DMSO (Dimethyl Sulfoxide)? A commonly used cryoprotectant for cells, is also a solvent for most common plastics.

What is the AC Pump Flow Rate? Rate at which AC is added to the extracorporeal circuit by the AC pump

CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY Typically (50% of patients) characterized by symmetric proximal and distal symmetrical muscle weakness, decreased sensation, and diminished or absent reflexes, that progresses and relapses for over two or more months.

What was 1968? According to the US Food & Drug Administration, this was the year that the first successful bone marrow transplant was performed.

What are white cells? These are targeted because they are underlying cause of disease.

What are (NK) natural killer cells? They are distinct subsets of lymphocytes within the innate immune system that mediate nonspecific lysis of target cells and produce variety of cytokines.

What is Inlet: AC Ratio The proportion of whole blood to AC in the extracorporeal circuit determines the concentration of AC in the extracorporeal circuit and the degree to which blood in the system is anticoagulated.

FAMILIAL HYPERCHOLESTEROLEMIA An autosomal dominant disorder due to mutations of hepatocyte apolipoprotein-B (apo-B) receptors producing decreased hepatic LDL removal. FH exhibits gene dosage: Homozygotes (HM) exhibit cholesterol of 650– 1, 000 mg/d. L, xanthomata by age 4 year, and death from coronary heart disease by age 20.

What are indwelling catheters? Complications such as arterial puncture, hematoma, arteriovenous fistula formation, bacterial colonization, hemothorax, hemorrhage and sepsis are frequently associated with this commonly required supply.

What is Chronic GVHD? Occurs in 30%– 60% of patients who receive an allogeneic stem cell graft.

What is -150 C? HPCs may be frozen in a cryoprotectant solution at temperatures that place the cells in metabolic stasis. What temperature is generally recommended for long term storage?

What is Inlet Pump Flow Rate The rate at which anticoagulated whole blood is drawn into the system by the inlet pump.

FOCAL SEGMENTAL GLOMERULOSCLEROSIS A histologically characteristic finding in renal biopsy specimen characterized by focal areas of sclerosis of some glomeruli adjacent to other intact glomeruli. Several FSGS histological variants (cellular, collapsing, tip lesion, perihilar, and not otherwise specified) exist, which have different clinical presentations and treatment response. 80% of FSGS cases are idiopathic.

What is heparin? Addition of this component to ACD-A has found favor in pediatric and LVL peripheral progenitor Cell collections to avoid hypocalcemia.

What is Sézary Syndrome ? Aggressive subtype of cutaneous T cell lymphoma (CTCL) that presents with erythroderma plus circulating malignant T lymphocytes with or without lymph node and/or visceral organ involvement.

What are HCT/Ps (Human cells. Tissues and cellular or tissue-based products) They are defined by the FDA as “articles containing or consisting of human cells or tissues that are intended for implantation, transplantation, infusion or transfer into a human recipient” and can be derived from either living or deceased donors.