Isotonix OPC3 Beauty Blend Managing beauty beneath the

Isotonix ® OPC-3 Beauty Blend “Managing beauty beneath the surface”

NUTRICOSMETICS Ingestible beauty products that can promote healthy skin, nails and hair Nutricosmetics has become a leading trend for consumers of all ages seeking a variety of beauty benefits, as listed below Teens: • quick fixes, skincare (acne) Women aged 20 -30: • skincare (aging prevention) Women aged 30 -50: • anti-aging & collagen Women aged 65+: • concerns about aging & bone health Active men: • physical appearance, sports nutrition The overweight population: • weight management, overall appearance, cellulite reduction, stretch mark removal

State of Industry: Nutricosmetics

What Makes Isotonix OPC-3® Beauty Blend Unique? • Contains all of the same active ingredients found in our top antioxidant supplement, Isotonix OPC-3 plus extra essential ingredients for holistic beauty health • Specially formulated to replenish vitamins and minerals that are known to be essential for the health of your skin • Delivered in an isotonic solution for faster delivery and absorption

The Importance of Isotonix OPC-3® in Beauty Blend • The formula for Isotonix OPC-3 Beauty Blend includes some of the most powerful bioflavonoids currently known to research scientists. • These bioflavonoids are scientifically termed oligomeric proanthocyanidins, commonly abbreviated OPCs. • Powerful free-radical scavenger that works to help keep you healthy and beautiful. • Coupled with specific vitamins, minerals and hyaluronic acid for a comprehensive and unique beauty formula • Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. • The best-researched OPCs are from grape seed, red wine, grape skin, bilberries, citrus fruit and Pycnogenol®. • Extensive research exists on Pycnogenol® making it one of the most researched ingredients in the natural product market.

What are the Benefits of Isotonix OPC-3® Beauty Blend • One of our most advanced beauty-care supplements • Contains key plant-based ingredients found in our top supplement Isotonix OPC-3 which are Pycnogenol®, red wine extract, bilberry extract, grape seed extract and citrus bioflavonoids complex • Also contains key vitamins, minerals, and ingredients like vitamin C, vitamin D, vitamin E, biotin, calcium, magnesium, and hyaluronic acid • Source of antioxidants for the maintenance of good health • Helps in wound healing • Helps in connective tissue formation • Aids in the normal development and maintenance of bones, cartilage, teeth and gums • Superior delivery of Isotonix • Suitable for vegetarians • Product contains no added wheat, yeast, gluten, artificial flavour, starch, preservatives or milk.

Research shows that Pycnogenol®, antioxidants, vitamins and minerals: • Supports a healthy complexion • Supports a smooth, soft, and even toned complexion • Promotes healthy functioning of the skin at the cellular level which results in healthy vibrant looking skin • Replenishes essential vitamins and minerals that are co-factors for many enzyme reactions in vivo to help the entire skin to grow and cells to divide • Helps maintain normal cell growth • Supports healthy skin with key micronutrients to replenish & rejuvenate skin to look, feel and function its absolute best • Supports healthy skin elasticity to keep skin looking young and firm (tight) • Helps maintain skin elasticity and moisture *The aforementioned has not been approved or considered by Health Canada. The aforementioned are findings made in diverse scientific studies regarding the ingredients in Isotonix Beauty Blend mentioned above.

(continued) • Helps maintain healthy connective tissue • Maintains healthy collagen and elastin levels to help preserve the elasticity of skin. • It also plays a role in maintaining elasticity of capillaries in the dermis which helps maintain healthy blood flow, minimizing the appearance of spider veins in the skin. • Helps maintain skin moisture • Helps maintain an optimal moisture balance in skin that can minimize the appearance of fine lines, wrinkles and pits • Promotes healing of minor skin injuries • Promotes healing of cuts and abrasions • Promoted healing of minor skin damage *The aforementioned has not been approved or considered by Health Canada. The aforementioned are findings made in diverse scientific studies regarding the ingredients in Isotonix Beauty Blend mentioned above.

(continued) • Helps support the skin’s natural defenses from harmful environmental pollutants and chemicals • Demonstrates anti-inflammatory activity to assist in normalizing reddened, swollen, or thick skin • Helps maintain microcirculation of skin capillaries for healthy oxygen and nutrient supply – part of our vascular system which “feeds” the skin to help keep it fresh and rejuvenated. • Powerful free radical scavenger • Supports the immune system – a healthy body means healthy looking skin. • Powerful antioxidant that provides the skin with a defense against damage and signs of aging • Helps maintain healthy hair and nails *The aforementioned has not been approved or considered by Health Canada. The aforementioned are findings made in diverse scientific studies regarding the ingredients in Isotonix Beauty Blend mentioned above.

Isotonix OPC-3® Beauty Blend Ingredients Grape Seed Extract Red Wine Extract Pine Bark Extract (Pycnogenol®) Bilberry Extract Citrus Extract (Bioflavonoids) Hyaluronic Acid (Sodium Hyaluronate) Vitamin C (Ascorbic Acid) Vitamin D 3 (Cholecalciferol) Vitamin E Acetate (d-Alpha-Tocopheryl-Acetate) Biotin Calcium (Lactate) Magnesium (Carbonate)

Grape Seed Extract (Vitis vinifera) & Red Wine Extract • Extremely rich in polyphenols, a compound high in antioxidants. • Helps maintain heart health • OPCs found in red wine are greatly beneficial to maintain general wellbeing.

Pine Bark Extract (Pycnogenol®) • Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. • Pycnogenol represents a natural combination of genetically programmed constant proportions of procyanidins, bioflavonoids and organic acids. • A powerful antioxidant • One of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. It has super-antioxidant capabilities. • More than 200 scientific articles and clinical trials have confirmed Pycnogenol’s safety, absence of toxicity and clinical efficiency over the past 35 years, making it one if the most researched ingredients in the natural product market.

Bilberry Extract (Vaccinium myrtillus) • Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. • Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, powerful antioxidants. • Supports healthy vision and venous circulation. • Helps maintain healthy circulation by strengthening capillaries, arteries and veins.

Citrus Extract (Bioflavonoids) • Bioflavonoids are found in certain plants to act as light filters protecting the delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. • Promotes cardiovascular health, • Helps maintain healthy circulation by strengthening capillaries, arteries, and veins and demonstrate antiinflammatory activity.

Hyaluronic Acid • A glycosaminoglycan distributed widely throughout connective, epithelial and neural tissues, and is commonly used in skin care products. • One of the main constituents of the extracellular matrix and promotes healthy cell proliferation and migration. • Supports healthy tissue hydrodynamics, movement and production of cells, and promotes a number of cell surface receptor interactions. • Supports joint health. • Promotes healthy cartilage cells. • Promotes healing of minor tissue injuries.

Vitamin C • Best known for its antioxidant properties and it may be the most important water-soluble antioxidant in the body. • Supports the immune system. • Helps to maintain healthy vision and skin. • Crucial role in maintaining healthy connective tissues including collagen, elastin, fibronectin, proteoglycans, bone matrix and elastin-associated fibrillin. • A lack of vitamin C can cause general fatigue. • Helps in moderating healthy iron absorption, transport and storage • Promotes the normal intestinal absorption of iron.

Vitamin D 3 • Promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. • Also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. • Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with frail bones and muscle weakness.

Vitamin E • Immune-boosting antioxidant. • Protects cell membranes from free radical damage. • Promotes normal wound healing and is known to help maintain a healthy cardiovascular system. one of the most powerful fat-soluble antioxidants in the body. • High servings have been shown to promote normal platelet activity.

Biotin • Promotes the normal metabolism of fats, carbohydrates and protein • Operates as an important part of several enzymes, acting as a coenzyme implicated in energy metabolism (such as pyruvate carboxylase). • Promotes strong hair and nails, and healthy blood sugar levels • Increases energy levels • Helps maintain normal cholesterol.

Calcium • Supports normal muscle contraction and nerve conduction. • Supports normal heartbeat, blood coagulation and glandular secretion, the production of energy. • Helps maintain normal immune function. • Essential for healthy bones and teeth. • Necessary for maintaining bone density. • Plays a role in promoting cardiovascular health.

Magnesium • Helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. • Promotes the mobilization of calcium • Plays a key role in promoting the proper functioning of muscle and nervous tissue • Supports normal body temperature and metabolism regulation • Promotes proper nerve function, and helps the body adapt to stress. • Promotes strong bones and teeth and proper muscle development. • Helps the body maintain a regular heartbeat and normal blood pressure, promotes normal platelet activity and helps maintain normal cholesterol levels.

What is Isotonic? • Means “same pressure” • All fluids in the body have a certain concentration, referred to as osmotic pressure. • Allows a consistent maintenance of body tissues. • The body has less work to do to obtain maximum absorption. • Allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream • Absorption of nutrients are highly efficient while delivering maximum results

Delivery System

Why Isotonix OPC-3 ® Beauty Blend?

Isotonix OPC ® -3 Beauty Blend Code: UC: SR: BV: Servings: C 13997 $56. 50 $75. 50 43. 50 45 “Managing beauty beneath the surface”

References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. Bayeta, E. , et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249 -259, 2000. Blazsó, G. , et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharmacol Lett 3: 217 -20, 1994. Block, A. , and Bettelheim, F. Water Vapor Sorption of Hyaluronic Acid. Biochim Biophys Acta 201: 69, 1970. Chen, W. , et al. Functions of hyaluronan in wound repair. Wound Repair Regen. 7: 79 -89, 1999. Cho, K. , et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64 -71, 2000. Cho, K. , et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141 -156, 2001. Devaraj, S. , et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37: 931 -4, 2002. Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5: 144 -51, 2000. Fitzpatrick, D. , et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509 -515, 1998. Frankel, E. , et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454 -7, 1993. Freedman, J. , et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103: 2792 -8, 2001. Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663 -673, 2000. Ghersetich, I. , et al. Hyaluronic acid in cutaneous intrinsic aging. International Journal of Dermatology. 33(2): 119 -122, 1994. Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1 -13, 1999. Hosseini, S. , et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201 -209, 2001. Kohama, T. , et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30 -32, 1999. Kohama, T. , et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828 -32, 2004. Liu, X. , et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75: 250513, 2004. Liu, X. , et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004. Mac. Kay, N. , et al. Nutritional support for wound healing. Alternative Medicine Review. 8: 359 -77, 2003.

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