Iodine Isotopes Chemistry Radioactivity of Iodine Moataz Mohamed

Iodine Isotopes Ø Chemistry & Radioactivity of Iodine Moataz Mohamed Ø Radioisotope Therapy (RIT-I 131) Rowan Mohamed Shady

I- Chemistry of Iodine

Discovery of Iodine element by Bernard Courtois in 1811

Physical Properties • violet-dark gray solid • Density: 5 g/cm 3 • Melting Point: 114°C • Boiling Point: 185°C

Atomic Properties • Atomic Weight: 127 • Electrons/shell 2, 8, 18, 7 • 53 Proton • 74 Neutron

Occurrence on Earth

II- Radioactivity of Iodine

Iodine isotopes • Isotopes are atoms of the same element having the same number of protons but different number of neutrons. • There are 37 isotopes of Iodine Ex: I 127, I 129, I 131 … • The only stable isotope of Iodine is I 127.

Radiation & Half-life Period • If radiation is a form of energy …. . Then it can not be created (First Low of Thermodynamics). • So where does it come from? ? ? ! • The source of radiation is the loss in mass (E=MC 2) • Half-life period is the time after which the mass will reach half of its initial value. • Half-life period is very important in determining the time needed for the radioactive substance to completely decay.

III- Radioisotope Therapy (RIT -I 131)

Radiotherapy [ Iodine-131 ] • Definition. ØMedical use of IONIZING RADIATION in treatment of Cancer and Malignant cells. ØRadiotherapy Vs. Radiology ! ! • History of Radiotherapy : ØWilhelm Conrad Röntgen ØMarie Curie

Radiotherapy [ Iodine-131 ] • Mechanism of action : ü DAMAGE OF DNA. . Both strands ? ü Damage is inherited in cancerous cells. ü Free radicals ( hydroxyl radicals ).

Radiotherapy [ Iodine-131 ] • Radioisotope Therapy ( RIT ) INFUSION 1. MIBG: Neuroblastoma 2. ORAL IODINE 131: Thyrotoxicosis 3. RADIOACTIVE GLASS : Hepatic cancer INGESTION

Radiotherapy [ Iodine-131 ] FELINE HYPERTHYRODISM • Procedure. . • Advantages. . • Disadvantages. .

Radiotherapy [ Iodine-131 ] • Radiation protection. Based on : Time Distance Shielding

Radiotherapy [ Iodine-131 ] 1 - Reducing the time of an exposure reduces the effective dose proportionally. 2 - Increasing distance reduces dose due to the inverse square law. 3 - Adding shielding can also reduce radiation doses.

Thank You References: • http: //en. wikipedia. org/wiki/Isotopes_of_io dine • Merck Index of Chemicals and Drugs, 9 th ed. • General Chemistry (volume 2) by N. L. Glinka, Mir Publishing 1981 • General Chemistry by Linus Pauling, 1947 ed. • Chemical Supplier Convicted of Diversion of Iodine Moataz Mohamed Rowan Mohamed Muhamed Shady