Inward currents 1 2 0 INa Outward currents

Extracellular space Na Cardiac Action Potential K+ channel + Na+ K+ Cytoplasm Na+ channel

Slides: 3

Inward currents 1 2 0 INa Outward currents 1 2 0 m. V 3 4 60 -120 p. A/p. F Ito 4 5 -10 p. A/p. F 5 p. A/p. F IK 1 5 -7 p. A/p. F ICa(L) INa. Ca 3 0 Iss ICa(T) 0 m. V 5 -10 p. A/p. F 1 -2 p. A/p. F 0. 5 -2 p. A/p. F IKs IKr INa. K 1 -2 p. A/p. F 1 p. A/p. F 0. 5 p. A/p. F Slide courtesy of Bjorn Knollmann, MD, Ph. D Vanderbilt University

Extracellular space Na Cardiac Action Potential K+ channel + Na+ K+ Cytoplasm Na+ channel Ca 2+ + + Na. Na Ca 2+ Cytosolic [Ca 2+] T-tubule Junctin Na/Ca exchanger Triadin Ca 2+ Casq Ca 2+ 2+ CSQ Ca Ca Ca 2+ CSQ Casq 2+ Ca Ca 2+ 2+ 2+ Ca Ca Ca 2+ Sarcoplasmic reticulum Ca 2+ PLB Ca 2+ channel Ryanodine 2+ Casq Ca 2+ receptor Ca 2+ 2+ Ca Ca Ca 2+ K+ ATPase Ca 2+ ATPase Cytoplasm loaded with Ca 2+ fluorescent indicator Ca 2+ Na+ Ca 2+ Tn. C Na+ pump Contractile filaments Slide courtesy of Bjorn Knollmann, MD, Ph. D Vanderbilt University