Introduction to the NIHR Research Design Service Dr

Introduction to the NIHR Research Design Service Dr Bernadette Egan University of Surrey Research Design Service- South East 02/06/2015 SECCN/SPACe. R Critical Care Conference

The NIHR Health Research System Faculty Investigators & Senior Investigators Trainees Associates Research Infrastructure Clinical Research Networks Clinical Research Facilities, Centres & Units Universities NHS Trusts Research Projects & Programmes Patients & Public Research Design Service & CTUs Research units & Schools Research Governance Systems 02/06/2015 Research Information Systems

NIHR Remit • Support of applied health research • Research has a clear potential to benefit patients and the public within 3 -5 years • Involvement of patients and public in research design • The research can involve patients, samples or data from patients, people who are not patients, populations, health technology assessment and health services research • NIHR does not support basic research or work involving animals and/or animal tissue Research Design Service

Research Design Service “To increase the number and proportion of high quality applications for funding …” http: //www. ccf. nihr. ac. uk/Pages/RDSMap. aspx 02/06/2015

RDS South East 02/06/2015

RDS team at Surrey • • Dr Bernadette Egan: Academic Lead/Research Adviser Dr Jo Leftwich: Research Adviser (currently on maternity leave) Professor Heather Gage: Health Economist/Research Adviser Dr Dan Jackson: Health Economist Mr Jake Jordan: Health Economist Dr Jeewaka Mendis: Medical Statistician Mr Peter Williams: Medical Statistician Miss Kay Stephenson: Patient & public involvement & general support Research Design Service

How can the RDS help? Research Question Ideas

How can the RDS help? Scope Appropriate funding stream Peer-reviewed journals Grey literature Registered trials database Literature Research Question

How can the RDS help? Cohort, case-control, RCT, ethnographic, interview Study Design Scope Appropriate funding stream Peer-reviewed journals Grey literature Registered trials database Literature Research Question

How can the RDS help? Cost issues Recruitment Appropriate time scale? Cohort, case-control, RCT, ethnographic, interview Feasibility Study Design Scope Appropriate funding stream Peer-reviewed journals Grey literature Registered trials database Literature Research Question

What to cost & who will pay? • Costs of R&D in the NHS are split into 3 categories; • Research Costs • NHS Support Costs (service support) • Treatment Costs http: //www. crncc. nihr. ac. uk/researchers/planning_your_study/Aco. RD Research Design Service

How can the RDS help? Cost issues Recruitment Appropriate time scale? Cohort, case-control, RCT, ethnographic, interview Meaningful & appropriate Involvement Feasibility of patients and public Study Design Scope Appropriate funding stream Peer-reviewed journals Grey literature Registered trials database Literature Research Question

PPI • INVOLVE http: //www. invo. org. uk/ • Involvement Cost Calculator http: //www. invo. org. uk/resource-centre/involvementcost-calculator/ “Were patients and the public actively involved in either identifying the research topic/prioritising the research question and/or preparing this application? ” Research Design Service

How can the RDS help? Cost issues Recruitment Appropriate time scale? Cohort, case-control, RCT, ethnographic, interview Meaningful & appropriate Involvement Feasibility of patients and public Study Research Design team Scope Appropriate funding stream Peer-reviewed journals Grey literature Registered trials database Literature 07/05/2015 Multidisciplinary team Research Question

Highlight the Skill mix • Relevant skills and experience in the team? • Adequate staffing for all elements of the project? • Appropriate project management? • ‘Sell’ previous experience of the team • Limited experience of running research? Research Design Service

How can the RDS help? Cost issues Recruitment Appropriate time scale? Cohort, case-control, RCT, ethnographic, interview Meaningful & appropriate Involvement Feasibility of patients and public Multidisciplinary team Study Research Design team Scope Consent Appropriate Ethical funding stream considerations Peer-reviewed journals Grey literature Registered trials database Literature 07/05/2015 Research Question

How can the RDS help? Cost issues Recruitment Appropriate time scale? Cohort, case-control, RCT, ethnographic, interview Meaningful & appropriate Involvement Feasibility of patients and public Multidisciplinary team Study Research Design team Scope Consent Appropriate Ethical funding stream considerations Peer-reviewed journals Grey literature Registered trials database Literature Research Question Proposal Benefit to NHS and patients Impact Slides 8 -20 courtesy of Dr Wendy Baird , RDSYH

Who can access the RDS? • NHS staff applying for funding for research • Academics working with (or planning to work with) NHS staff on a research funding application • NIHR Fellowship applicants • Do not have to be applying for NIHR funding (any non-commercial funding in applied health and social care) Research Design Service

NIHR Programmes • • • Efficacy and Mechanism Evaluation (EME) Health Services & Delivery Research (HS&DR) Health Technology Assessment (HTA) Invention for innovation (i 4 i) Public Health Research (PHR) • Programme Grants for Applied Research (PGf. AR) • Programme Development Grants (PDG) • Research for Patient Benefit (Rf. PB) (PGf. AR, PDG and Rf. PB funding must be held by an NHS institution) Research Design Service

Research for Patient Benefit • Regional programme • Any area of research leading to patient benefit • Up to £ 350 k for 3 years • Funding must be awarded to an NHS Trust, so an NHS partner needed Often funds feasibility projects (£ 250 K) Research Design Service

Health Technology Assessment • Both commissioned and investigator-led calls • Evaluation of interventions, often involving a clinical trial • Primary and secondary research on the effectiveness of new technology -‘Technology’ interpreted widely • Feasibility studies & pilot studies now eligible Research Design Service

Health Technology Assessment Typical HTA randomised control trial: Multidisciplinary and multi-centre (requires CTU) Effectiveness and cost-effectiveness (requires health economics) Median number of patients = 700 (Range of 15 to 100, 000 across current projects) Average duration 4 -5 years Average cost over £ 1. 5 million Research Design Service

Health Services and Delivery Research to improve the quality, effectiveness and accessibility of the NHS, including evaluations of how the NHS might improve delivery of services. Considers both primary & secondary research Pilot and feasibility studies considered Relevant areas of social care as well as health are considered Funding generally over £ 400 K Research Design Service

Programme Grants for Applied Research Prestigious awards directed towards leading researchers who can demonstrate an impressive track-record of achievement in applied health research • Up to £ 2 m over 5 years • Awarded to an NHS Trust • Each programme funds a series of related projects, which form a coherent theme in an area of priority or need for the NHS Research Design Service

Programme Grants for Applied Research Emphasis is on delivering research findings that will have practical application for the benefit of patients, typically through improved health care or better health care delivery • Balanced teams of leading researchers, from the NHS and academia Have a multidisciplinary approach to research (including clinical, health economics, statistics, qualitative and behavioural sciences) Involvement of multiple sites essential Research Design Service

NIHRTCC Research Career Pathways All Professions NIHR Fellowships, Professorships and Other Awards NIHR Research Professorship Healthcare Scientists Healthcare Science Programme Nurses, Midwives, Allied Health Professionals Clinical Academic Training NIHR Integning. Programme Chair Methodologists Research Methods Programme Level of Doctors and Dentists Award --------------------------------------------------------------- Senior/ Pre. Chair NIHR/HEE Senior Clinical Lecturership NIHR Senior Research Fellowship NIHR/HEE Clinical ----------------------------------------------------------------Lectureship NIHR/HEE NIHR Health Care Post. Clinical Science Doctoral Lectureship Post-Doctoral Fellowship NIHR Clinician Scientist Award Post Doctoral (early to senior) NIHR Career Development Fellowship NIHR Transitional Research Fellowship NIHR Clinical Trials Fellowship NIHR Knowledge Mobilisation Research Fellowship ----------------------------------------------------------------NIHR Doctoral Research Fellowship NIHR/HEE Clinical Doctoral Research Fellowship ---------------------------------------------------------------- Pre Doctoral NIHR Masters Studentship in Health Economics ---------------------------------------------------------------or Medical NIHR Statistics NIHR/HEE In-Practice Fellowship Masters in NIHR Research Clinical Methods NIHR Academic Research Fellowship and Clinical Fellowship Internship Doctoral NIHR/HEE Health Care Science Doctoral Fellowship Undergraduate

http: //www. rds-se. co. uk/ 07/05/2015 SECCN/SPACe. R Critical Care Conference