Introduction to Neurobiology Channel Physiology Sanjay Manohar Gonville
Introduction to Neurobiology & Channel Physiology Sanjay Manohar Gonville and Caius College, University of Cambridge 2001 http: //www. smanohar. com
Neurobiology NST IB Questions • • Methods, development & general Synapses, sensory transduction & processing Cutaneous sense Sensory feedback from muscle Posture Higher control of movement Special senses Higher cortical & limbic function
Lecture topics • • • History and Philosophy Electrical properties Chemical properties Neural determination Vision Hearing
Discuss the Locatisation of function in the Cerebral Cortex
Discuss the Locatisation of function in the Cerebral Cortex • History • Methods • Conculsion
Types of evidence • • Stimulation Recording Imaging Lesion Pharmacology Microanatomy Comparative Developmental
Channel Drugs • • Glycosides (Ouabain, Digoxin) Tetrodotoxin (TTX) Tetraethylammonium (TEA), Caesium Cyanide, Dinitrophenol (DNP)
Channel studies • • Extracellular electrode Intracellular electrode Voltage clamp Patch clamp Gene knockout Sequencing, crystallography Numerical simulation
Channel comparisons
H&H Predictions • • • Repeated firing Threshold Refractoriness Stability Conduction speed Subthreshold oscillations • AP shape • Charge movement • Kinetic behaviour of channel
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