Introduction to ACE inhibitors ACE inhibitor Captopril Pharmaceutical
Introduction to ACE inhibitors
ACE inhibitor Captopril • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: ACE inhibitor • Structure-based explanation of Therapeutic uses: heart failure, Hypertension. They are taken on an empty stomach to increase F. • Structure-based explanation of Side effects: Hyperkalemia, angioedema, dry cough, fetotoxic. • Analysis.
ACE inhibitor Enalapril (vasotec) • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: • Structure-based explanation of Therapeutic uses • Structure-based explanation of Side effects: • Analysis.
ACE inhibitor Lisinopril • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: • Structure-based explanation of Therapeutic uses • Structure-based explanation of Side effects: • Analysis.
ARB Candesartan • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: Angiotensin-receptor blocker (ARB) • Structure-based explanation of Therapeutic uses: HF, Hypertension, substitute ACE for patients with dry cough and angioedema. • Structure-based explanation of Side effects: contraindicated in pregnancy. • Analysis.
ARB Losartan • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: • Structure-based explanation of Therapeutic uses • Structure-based explanation of Side effects • Analysis.
Renin inhibitor Aliskiren • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: selective renin inhibitor. Rennin increases angiotensin II synthesis whenever the renal blood flow decreased (Keeping the body fluids). • Structure-based explanation of Therapeutic uses: Hypertension (effective as ARB) • Structure-based explanation of Side effects: diarrhea, dry cough, angioedema, hyperkalemia and fetotoxic. • Analysis.
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