INTRODUCTION GLUCOCOR MINERALO CORTICOIDSS Hydrocortiso Aldosterone ne MECHANISM
- Slides: 12
INTRODUCTION • GLUCOCOR • MINERALO CORTICOIDSS ØHydrocortiso ØAldosterone ne
MECHANISM OF ACTION • MEDIATED THROUGH Lipocortin 1. INHIBITS-PHOSPOLIPASE 2. INHIBITS-PRODUCTION OF INTERLEUKIN-2 3. INHIBITS-RELEASE OF LYMPHOKINES
CLINICNAL APPLICATION v. REPLACEMEN T THERAPYAdrenal insufficiency v. SUPPRESION OF IMMUNE RESPONCE
DENTAL INDICATION Ø Endodonticsealer Ø Desensitizer Ø Pulp capping Ø Aphthous ulcer Ø Angular cheilites Ø Stomatitis-med Ø Lichen planus Ø Erethema multiformae Ø Pemphigus Ø Oral submucous fibrosis Ø Postsurgical trismus Ø Dental fractures
MEDICAL INDICATION Ø Adrenal dysfunction Ø Liver dysfunction Ø Cardiac dysfunction ØG I T Ø Blood Ø Renal Ø Allergy Ø Malignancies Ø Dermatological Ø Collagen disorders Ø Organ transplant Ø Antiinflamatory
CONTRAINDICATIONS ØPeptic ulcer ØDiabetes ØHypertension ØPregnancy ØPsychosis ØTuberculosis Ø Fungal infection Ø Herpes infection Ø Occular herpes Ø Osteoporosis Ø Glaucoma Ø Renal insufficiency
ADVERSE EFFECTS CARBOHYDRATE METABOLISM Ø Increases blood sugar Ø Ø Aggravate preexsisting dm Prediabetic patients. PROTEIN METABOLISM Ø Muscle wasting, loss of bone Ø increased capillary fragilit Ø Healing&fibrosis-inhibited
ADVERSE EFFECT(contd) Ø MINERAL METABOLISM Sodium&water retension increased potassium loss lead to oedema& BP Ø FAT METABOLISM Deposition of fat Moon facies Buffalo hump
ADVERSE EFFECT-(contd) • INFLAMATION ØInflammatory response reduced IMMUNITY ØCell mediated immunity reduced ADRENOCORTICO SUPPRESION ØGrowth in child arrested
DRUGS BETAMETHASONE Trade names: Betnesol Betacortril Betnelan DEXAMETHASONE Trade names: Dexona Methacort
DRUGS TRIAMCINALONE Trade names: kenacort Kenalog Tess Tricort PREDNISOLONE Trade names: wysolone